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  • 1
    Electronic Resource
    Electronic Resource
    Structure-function relationship in Escherichia coli initiation factors I. Phosphorylation of IF-3 by coliphage T7 protein kinase
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 77 (1977), S. 1517-1524 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(77)80150-2
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  • 2
    Electronic Resource
    Electronic Resource
    Physiology The pitfalls of power laws (2002)
    [s.l.] : Nature Publishing Group
    Nature 417 (2002), S. 131-132 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Why does a mouse burn six times more energy per unit body mass per minute than a human? The intuitive answer is to keep warm. In 1883, Rubner found that the metabolic rate depended on the body's surface-to-volume ratio, or M2/3, where M is the body mass, thus supporting the notion of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/417131a
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  • 3
    Electronic Resource
    Electronic Resource
    Structure-function relationship in Escherichia coli initiation factors I. Phosphorylation of IF-3 by coliphage T7 protein kinase
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 77 (1977), S. 1517-1524 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(77)80150-2
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    MIR '92: a joint Russian-German space mission (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 675-677 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00209719
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  • 5
    Electronic Resource
    Electronic Resource
    Absence of acid phosphatase activity in specific endothelial organelles (1969)
    Springer
    Histochemistry and cell biology 20 (1969), S. 143-149 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Endothelial specific organelles in the aorta and in the small pulmonary blood vessels were investigated by electron microscopy with respect to their acid phosphatase activity. As controls, acid phosphatase reactions performed on liver and lung tissue showed, as expected, positive results. Since the endothelial specific organelles were in each case free of reaction product, it was concluded that they do not have a lysosomal function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00268708
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  • 6
    Electronic Resource
    Electronic Resource
    The ultrastructure of the normal human skeletal muscle (1973)
    Springer
    Pflügers Archiv 344 (1973), S. 217-232 
    Details
    ISSN: 1432-2013
    Keywords: Morphometry ; Skeletal Muscle ; Aerobic Power ; Training ; Sex Differences
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Muscle biopsies were taken from the middle part of the vastus lateralis muscle of 9 men, who were not regularly involved in endurance training (M, average $$\dot V_{{\text{O}}_{\text{2}} } $$ max=61.3 ml/min·kg), 3 sedentary women (W, $$\dot V_{{\text{O}}_{\text{2}} } $$ max=43.7 ml/min·kg) and 5 well trained orienteers (TO, $$\dot V_{{\text{O}}_{\text{2}} } $$ max=76.1 ml/min·kg). Morphometric analysis of 60 electron micrographs per biopsy gave the following significant differneces: 1. The volume density of central mitochondria was 1.47-fold higher in TO than in M, and 1.44-fold higher in M than in W. 2. The volume density of peripheric mitochondria was 3.22 times higher in TO compared to M. 3. The ratio of the central mitochondrial volume to the volume of myofibrils was 1.54-fold higher in TO compared to M, while the respective ratio was 1.49 for M compared to W. 4. The surface of the central mitochondria was 1.28-fold higher in TO than in M and 1.35-fold higher in M than in M. 5. The surface of mitochondrial cristae was higher by a factor of 1.62 in TO compared to M and 1.35 in M compared to W. 6. The central mitochondria were larger in TO compared to M by a factor of 1.12. 7. The volume density of intracellular lipid (triglyceride droplets), was 2.5-fold higher in TO than in M. There were highly significant correlations between $$\dot V_{{\text{O}}_{\text{2}} } $$ max and volume density of central mitochondria (r=0.82), surface of mitochondrial cristae (r=0.80) and the ratio of mitochondrial volume to myofibrillar volume (r=0.78). No quantitative changes could be observed in mitochondrial fine structure. Neither volume density of sarcoplasma nor volume and surface density of the tubular system showed any difference as a function of training and sex. It is postulated that a) an individual's maximum oxygen intake is limited not only by the capacity of the oxygen transport system but also by the oxidative capacity of mitochondria in the skeletal muscles, and b) the skeletal muscle of trained athletes contains a much higher quantity of intracellular lipids (triglyceride droplets) as a substrate directly available for energy production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588462
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  • 7
    Electronic Resource
    Electronic Resource
    CA 125 und PNCA (Proliferating Cell Nuclear Antigen) beim Ovarial-Ca, ein 10-jähriger klinischer Verlauf (1993)
    Springer
    Archives of gynecology and obstetrics 254 (1993), S. 938-940 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02266244
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  • 8
    Electronic Resource
    Electronic Resource
    HLA-DR-MT matching improves graft survival rate in cadaver kidney transplantation (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 17-23 
    Details
    ISSN: 1432-1440
    Keywords: MHC ; Cadaver kidney transplantation ; Graft survival rate ; Blood transfusions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of prospective HLA-DR matching on the graft survival rate was investigated in a multicenter analysis of 85 transplants. Simultaneously in a retrospective analysis of graft outcome the importance of matching for MT-antigens MT1, MT2 and MT3 as a newly defined B-cell alloantigen system was evaluated. HLA-DR antigens and MT-specificities were determined on B-cells enriched by nylon-wool filtration using locally well characterised HLA-DR antisera and the antiserum set of the 8th International Histocompatibility Workshop (“discase set”) which allowed the definition of the HLA-DR specificities HLA-DR 1–9 and of the MT-antigens MT 1–3. HLA-DR matching showed a significantly improved graft outcome only in HLA-DR identical donor-recipient combinations. In 11 of 60 patients with one HLA-DR compatibility additional matching for two MT-antigens, however, improved the two year graft survival rate from 60% to 91%. Altogether 17 patients were matched for two MT-specificities with their kidney donor and showed a superior prognosis of 94% at two years compared to 53% or 17% of recipients with one or zero MT compatibility. Graft outcome in this patient group was also superior to that of HLA-DR identical or HLA-AB identical grafts. These data suggested that the MT-system rather than the HLA-DR antigens may be of critical importance in cadaver kidney transplantation. In addition a favorable influence of pretransplant blood transfusions on less HLA-DR matched grafts was confirmed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01484435
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  • 9
    Electronic Resource
    Electronic Resource
    c-erB-2 Onkogenexpression in Ovarialkarzinomen und Borderline-Tumoren (1993)
    Springer
    Archives of gynecology and obstetrics 254 (1993), S. 942-943 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Die Überexpression des c-erbB-2 onkogen-kodierten Proteins p 185 wurde immunhistochemisch an Paraffinmaterial bei 18/77 Ovarialkarzinomen (23%) und 3/25 Borderline-Tumoren (12%) nachgewiesen. Die klinische Nachbeobachtungszeit von bis zu 10 Jahren zeigte geringgradig kürzere Überlebenszeiten bei Patientinnen mit c-erbB-2 überexprimierenden Ovarialkarzinomen. Die Ergebnisse waren jedoch statistisch nicht signifikant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02266246
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  • 10
    Electronic Resource
    Electronic Resource
    Elektronenmikroskopische Untersuchungen an spezifischen Organellen von Endothelzellen des Frosches (Rana temporaria) (1970)
    Springer
    Cell & tissue research 108 (1970), S. 105-126 
    Details
    ISSN: 1432-0878
    Keywords: Endothelium ; Specific organelles ; Ultrastructure ; Rana temporaria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Endothelzellen der Wirbeltiere enthalten spezifische Organellen, deren Funktion unbekannt ist. Diese Organellen werden beim Frosch (Rana temporaria) nach unterschiedlichen Fixierungen elektronenmikroskopisch untersucht. Die Organellen sind walzenförmig mit mannigfachen Abweichungen, bis zu 2μ lang und 0,1 bis 0,5μ dick. Ihre oft unterbrochene Außenmembran ist dicker als zytoplasmatische Membranen. Das Innere der Organellen besteht aus Tubuli, die in eine elektronendichte Matrix eingebettet sind. Die Dichte dieser Matrix zeigt deutliche Abstufungen. Die Tubuli sind möglicherweise aus einer spiralförmigen Molekülkette aufgebaut. Das Verteilungsmuster der Organellen wird mit stereologischen Methoden untersucht. Die größte Volumendichte weisen die Aortae thoracicae mit 8% auf. Die Volumendichte der Organellen im Zytoplasma der Endothelzellen scheint mehr von der Entfernung der betreffenden Gefäßstrecke zum Herzen abzuhängen als von der Gefäßgröße. Es werden Verbindungen der Organellen zu zytoplasmatischen Membransystemen aufgezeigt. Auf Besonderheiten des Endothels, darunter Aggregationen von Ribosomen, wird hingewiesen.
    Notes: Summary Endothelial cells of vertebrates contain specific organelles of unknown function. These organelles are studied by electron microscopy with different fixations. The organelles are rod-shaped with many variations, up to 2μ in length and 0.1 to 0.5 μ in thickness. Their outer membrane, which is often discontinuous, is thicker than cytoplasmic membranes. The density of the matrix shows distinct gradations. The organelles contain tubules, possibly built up by a spiral molecular chain. The distribution of the organelles is investigated with stereological methods. Their volume density in endothelial cell cytoplasm appears to depend more on the distance from the heart than on vessel size, the thoracic aortae showing the highest organellae content of 8%. Connections between organelles and cytoplasmic membranes are demonstrated. Particularities of endothelium, among them aggregations of ribosomes, are pointed out.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335946
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