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  • 1
    Electronic Resource
    Electronic Resource
    Acute cardiac toxicity in patients after doxorubicin treatment and the effect of combined tocopherol and nifedipine pretreatment (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 143-147 
    Details
    ISSN: 1432-1335
    Keywords: Doxorubicin ; Acute cardiac toxicity ; Prevention
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In two groups of female patients with metastatic breast cancer who had all been pretreated with doxorubicin (350 mg/m2), acute cardiac effects following i.v. doxorubicin bolus injection (60 mg/m2) were recorded on the basis of systolic time intervals (STI). In six patients who received doxorubicin only the ratio between the heart-beat-corrected preejection period and left ventricular ejection time (PEPI:LVETI) as well as the PEP index were found to be significantly increased with a peak at 6 h following drug infusion (P〈0.001). Another six patients received an identical chemotherapeutic regimen and, in addition, a combination of tocopherol (200 mg i.m. 6 h before treatment) and nifedipine (60 mg p.o. daily from 2 days before doxorubicin infusion). In the pretreatment group, the PEPI: LVETI ration and PEP index remained unchanged during the posttreatment period. Pharmacokinetic analysis of drug concentrations in the plasma revealed a significantly accelerated distribution and elimination of doxorubicin after combined tocopherol and nifedipine pretreatment, although no statistically significant differences could be found in calculated drug levels in the peripheral compartment between both treatment groups. Our results indicate that acute cardiac reactions reflected by changes in STI values can be prevented by combined tocopherol and nifedipine pretreatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00395393
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  • 2
    Electronic Resource
    Electronic Resource
    Quantification of tissue distribution of antibiotics by kinetic hysteresis analysis (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 517-522 
    Details
    ISSN: 1432-1041
    Keywords: Antibiotics, Tissue distribution ; kinetic hysteresis, analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Distribution of antibiotics can be described by kinetic hysteresis analysis when concentrations are measured in the serum and an extravascular sampling site. By calculating the area of the hysteresis loop (a simple formula is presented), the relative amount of drug transferred to an extravascular site can be quantified. With this approach, changes in disposition characteristics can be evaluated under various pathophysiological conditions. In addition, a specific distribution coefficient may be derived for any drug when different dose levels are studied under identical conditions. Kinetic hysteresis analysis overcomes the drawback of conventional compartment model pharmacokinetic analysis, since no simultaneous fitting of two different concentration-time courses is feasible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02285094
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  • 3
    Electronic Resource
    Electronic Resource
    Erhöhung der Serum-Sialyltransferase bei menschlichen Malignomen: Grundlage für ein neues Diagnosticum? (1977)
    Springer
    Journal of molecular medicine 55 (1977), S. 553-555 
    Details
    ISSN: 1432-1440
    Keywords: Sialyltransferase activity ; Malignant diseases ; Immobilized acceptor ; Sialyltransferase-Aktivität ; Maligne Erkrankungen ; Trägergebundener Akzeptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Sialyltransferase-Aktivität von Patienten mit malignen Erkrankungen wurde den Werten von Personen gegenübergestellt, die keine klinischen Symptome und Beschwerden aufwiesen. Dabei zeigte sich, daß in 80% der untersuchten pathologischen Fälle eine deutliche Erhöhung der Serum-Sialyltransferase im Vergleich zum Normalkollektiv festgestellt werden konnte. Ferner konnten wir durch kovalente Bindung von Asialo-Fetuin als Akzeptor an Sepharose 4B eine Vereinfachung der Bestimmungsmethode erreichen.
    Notes: Summary Sialyltransferase activity was estimated in serum samples of patients with cancer and controls using immobilized asialo-fetuin as the acceptor and cytidine-5′-monophospho [14C] sialic acid as the donor. The data suggest that increased enzyme activity can be found in more than 80% of the samples from patients with malignant diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01489351
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  • 4
    Electronic Resource
    Electronic Resource
    Steigerung der Aufnahme Aminoacylierter Transferribonucleinsäuren menschlicher Leukocyten nach Genaktivierung durch Phytohæmagglutinin und bei Leukämie (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 138-142 
    Details
    ISSN: 1432-1440
    Keywords: Gene activation ; leukemia ; phytohaemagglutinin ; transfer ribonucleic acids ; cell permeation ; Genaktivierung ; Leukämie ; Phytohaemagglutinin ; Transfernucleinsäuren ; Zellpermeation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die in dieser Arbeit vorgelegten Ergebnisse liefern Hinweise, die für den Transport von Transfernucleinsäuren durch die Zellmembran in das Zellinnere und für das Vorliegen dieser Verbindungen in undegradierter Form intracellulär sprechen. Diese Aufnahme ist offensichtlich vom Reife- und Differenzierungsgrad von Leukocyten abhängig, da leukämische Zellen oder Blasten höhere Inkorporationsraten aufwiesen, als reife Zellen. Die Ergebnisse werden im Zusammenhang mit der Möglichkeit diskutiert, informationstragende Makromoleküle in funktionell intakte Zellen einzubringen.
    Notes: Summary The results presented in this paper provide evidence in favour of the partially undegraded transport of transfer ribonucleic acids through cell membranes of human leukocytes and of the intracellular integrity of these compounds. The magnitude of the uptake seems to depend on the grade of differentiation of blood cells; in as much as blast cells and leukemic cells appear to take up greater quantities. These results are discussed with respect to the possibility of introducing intact genetic material into living cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01620752
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  • 5
    Electronic Resource
    Electronic Resource
    Osteoblastisches Sarkom beim Rehwild-Ein Fallbericht (1986)
    Springer
    European journal of wildlife research 32 (1986), S. 125-128 
    Details
    ISSN: 1439-0574
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Summary This report describes an osteoblastic sarcoma above the left eye socket in a 6-year-old roe buck from the Steiermark area of Austria. Within a period of around 8 weeks, a visible swelling developed into an almost globular tumor the size of a fist. The osteoblastic sarcoma shows osteoid splinters, collagenous bundles of fibre and the concentration of anaplastic spindle cells. The polymorphism of the spindle cells and a marked resorption of the lamina externa point to the malignity of the process.
    Abstract: Résumé Description est faite d'un sarcome ostéoblastique de la fosse oculaire gauche chez un chevreuil mâle de 6 ans originaire de Styrie (Autriche). Endéans les 8 semaines environ, s'était formée, au départ d'un gonflement visible, une tumeur ovoïde de la grosseur d'un poing. Le sarcome ostéoblastique montre un élément ostéoïde, un faisceau de fibres collagènes et une accumulation de cellules fusiformes anaplastiques. La polymorphie des cellules fusiformes et une résorption marquée desLamina externa accréditent le caractère malin du processus.
    Notes: Zusammenfassung Es wird ein osteoblastisches Sarkom oberhalb der linken Augenhöhle bei einem 6jährigen Rehbock aus der Steiermark, Österreich, beschrieben. Innerhalb von etwa 8 Wochen hatte sich, ausgehend von einer sichtbaren Schwellung, ein fast kugelrunder, faustgroßer Tumor entwickelt. Das osteoblastische Sarkom zeigt osteoide Bälkchen, kollagene Faserbündel und die Anreicherung von anaplastischen Spindelzellen. Die Polymorphie der Spindelzellen und eine markante Resorption der Lamina externa sprechen für die Bösartigkeit des Prozesses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02241246
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Osteoblastisches Sarkom beim Rehwild — Ein Fallbericht (1986)
    Springer
    European journal of wildlife research 32 (1986), S. 125-128 
    Details
    ISSN: 1439-0574
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Summary This report describes an osteoblastic sarcoma above the left eye socket in a 6-year-old roe buck from the Steiermark area of Austria. Within a period of around 8 weeks, a visible swelling developed into an almost globular tumor the size of a fist. The osteoblastic sarcoma shows osteoid splinters, collagenous bundles of fibre and the concentration of anaplastic spindle cells. The polymorphism of the spindle cells and a marked resorption of the lamina externa point to the malignity of the process.
    Abstract: Résumé Description est faite d'un sarcome ostéoblastique de la fosse oculaire gauche chez un chevreuil mâle de 6 ans originaire de Styrie (Autriche). Endéans les 8 semaines environ, s'était formée, au départ d'un gonflement visible, une tumeur ovoïde de la grosseur d'un poing. Le sarcome ostéoblastique montre un élément ostéoïde, un faisceau de fibres collagènes et une accumulation de cellules fusiformes anaplastiques. La polymorphie des cellules fusiformes et une résorption marquée desLamina externa accréditent le caractère malin du processus.
    Notes: Zusammenfassung Es wird ein osteoblastisches Sarkom oberhalb der linken Augenhöhle bei einem 6jährigen Rehbock aus der Steiermark, Österreich, beschrieben. Innerhalb von etwa 8 Wochen hatte sich, ausgehend von einer sichtbaren Schwellung, ein fast kugelrunder, faustgroßer Tumor entwickelt. Das osteoblastische Sarkom zeigt osteoide Bälkchen, kollagene Faserbündel und die Anreicherung von anaplastischen Spindelzellen. Die Polymorphie der Spindelzellen und eine markante Resorption der Lamina externa sprechen für die Bösartigkeit des Prozesses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02241341
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    Paper (German National Licenses)
    Fulltext
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