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  • 1
    Electronic Resource
    Electronic Resource
    Meniscal cyst in the posterior intercondylar space found by magnetic resonance imaging (1998)
    Springer
    Archives of orthopaedic and trauma surgery 117 (1998), S. 394-396 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a rare case of meniscal cyst from the posterior horn of the lateral meniscus, extending in the posterior intercondylar space of the right knee of a 15-year-old boy, in whom magnetic resonance imaging was very useful for evaluation. A cyst in this location has not been reported previously. The cyst was removed surgically, while preserving the lateral meniscus. A good result was obtained, and no recurrence has been seen in 12 months.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004020050276
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  • 2
    Electronic Resource
    Electronic Resource
    Abscess formation as a complication caused by postoperative osteomyelitis of the femur (1998)
    Springer
    Archives of orthopaedic and trauma surgery 118 (1998), S. 99-102 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report an unusual case of a giant femoral abscess caused by postoperative osteomyelitis after treating a fracture of the femoral shaft. The patient ignored it until the abscess began to interfere with knee flexion, but no symptoms of inflammation such as fever, pain or abnormal laboratory values were found. Within the marrow cavity, many plasma cells produced immunoglobulins G and M, and the level of these substances in the abscess fluid connected to the bony focus were higher than the serum levels. It was concluded that the inflammation in this case signified a peculiarity in a primarily chronic process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004020050322
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  • 3
    Electronic Resource
    Electronic Resource
    Use of arthroscopy and interporous hydroxyapatite as a bone graft substitute in tibial plateau fractures (1996)
    Springer
    Archives of orthopaedic and trauma surgery 115 (1996), S. 45-48 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tibial plateau fractures in 17 patients were managed arthroscopically, using interporous hydroxypatite (HA) as a bone graft substitute. Soft-tissue repair and intra-articular lavages were carried out arthroscopically, and depression of the articular surface was done by elevation of the subchondral plate by the bone compactor through a small window under image intensification and filling with HA through the tibial outer rim. Follow-up periods averaged 2 years and 6 months. According to roentgenograms and computed tomograms no development of arthrosis could be found. All of the patients have been followed to fracture union and have returned to their previous activity levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00453217
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  • 4
    Electronic Resource
    Electronic Resource
    Incomplete avulsion of the femoral attachment of the posterior cruciate ligament with an osteochondral fragment in a twelve-year-old boy (1990)
    Springer
    Archives of orthopaedic and trauma surgery 110 (1990), S. 55-57 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Isolated avulsion of the posterior cruciate ligament from the femoral attachment of the knee as a hyperextension injury is rare. We saw a young child with an incomplete avulsion of the posterior cruciate ligament that occurred after a blow to the anterior tibial surface of a flexed knee; the child revealed a lack of knee extension due to a pinch of the osteochondral fragment connected to the anterior band of the posterior cruciate ligament in the knee joint. Arthroscopic extirpation of a fragment was undertaken.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431368
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  • 5
    Electronic Resource
    Electronic Resource
    Local drug delivery system using ceramics: vacuum method for impregnating a chemotherapeutic agent into a porous hydroxyapatite block (1999)
    Springer
    Journal of materials science 10 (1999), S. 249-252 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract We performed an experimental study on a new drug delivery system that employs a porous hydroxyapatite block (HAb) (composition: Ca10 (PO4)6 (OH)2) to conduct sustained release of a chemotherapeutic agent. To confirm penetration of the agent into the HAb (2 cm3), an aqueous solution containing eosin dye was used at various vacuum pressures. To estimate the storage capacity of the HAb, blocks were weighed before and after being impregnated with the aqueous dye solutions, and the capacity of the block was calculated from the increase in weight after vacuum. In this slow-release study using vacuum, the anti-cancer drug methotrexate (MTX) was used in vitro. Four HAb (1 cm3) containing different concentrations of MTX, ranging from 1.22 to 2.38 mg per block, were studied. All were found to release the drug, maintaining a mean concentration of 0.22 to 0.32 μg/ml even after twelve days. This concentration is high enough to be effective against tumor cells. The results suggest that HAb impregnated with a chemotherapeutic agent using a simple vacuum system may serve as a valuable new method of administering local chemotherapy, primarily when used as a strut graft for bone defects. This new drug delivery system can also be used as an adjuvant material in extended curettage, which can also discourage recurrence of benign tumors without any risk of systemic toxicity. © 1999 Kluwer Academic Publishers
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008966314075
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  • 6
    Electronic Resource
    Electronic Resource
    Quantitative analysis of hyaluronan in the synovial tissues of patients with joint disorders (1998)
    Springer
    Clinical rheumatology 17 (1998), S. 261-262 
    Details
    ISSN: 1434-9949
    Keywords: Bioassay ; Hyaluronic acid ; Hyaluronic acid binding protein ; Synovial membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Quantitative analysis of hyaluronan (hyaluronic acid; HA) in the synovial tissues of patients with joint disorders were performed. HA was found not only in the synovial intimal cells and matrices, but also especially in the alveolar lymphoid follicles and connective tissues surrounding blood vessels in the inflammatory granular synovium which formed the pannus. HA levels in the synovium of patients with rheumatoid arthritis (RA) (459.0±66.2 μg/g) where shown to be higher than those in patients with osteoarthritis (246.9±34.8 μg/g) and traumatic injury (227.7±35.4 μg/g). It follows from the present findings, HA in the synovium might contribute to the high amounts of serum levels of HA in patients with rheumatoid arthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01451063
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  • 7
    Electronic Resource
    Electronic Resource
    The sustained release of antibiotic from freeze-dried fibrin-antibiotic compound and efficacies in a rat model of osteomyelitis (1997)
    Springer
    Infection 25 (1997), S. 359-363 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The kinetics of drug release from fibrin adhesive agent (consisting of fibrinogen, factor 8, thrombin, aportinin and calcium chloride)-antibiotic compound and efficacy on rat experimental osteomyelitis were studied. To enhance the slow release activities of antibiotic, a mixture of fibrin clots was freeze-dried. Effects of freeze-drying were to make a fibrin clot an interlinked pore and to increase crosslinking rate containing an antibiotic. A diffusion test from aminoglycoside (Arbekacin Sulfate: 200 mg) compound was carried out.In vitro study freeze-dried antibiotic compound (FFAC: 1 cm3) was placed in saline (3 ml). The saline was replaced every 48 h and the previous solution was stored at −45°C until assay. The result was that a concentration of 0.4 mg/l, sufficiently high to controlStaphylococcus aureus strain IM2-42, was maintained within nine exchanges of saline after 18 days.In vivo animal experiments, FFAC (2×2×3 mm) were tested in rats with establishedStaphylococcus aureus osteomyelitis in the proximal tibia. The animals were observed for radiographic signs of infection and tissue was examined histopathologically. Bacterial counts by bone cultures were statistically lower in rats implanted with FFAC than in those only given a drug-free FFC and curettage. Radiographical and histological observations also showed beneficial effects of the FFAC. The results suggest that the FFAC provide a simple drug delivery system, and may be a promising alternative treatment for osteomyelitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01740818
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