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  • 1
    Electronic Resource
    Electronic Resource
    Expression and somatic mutation on androgen receptor gene in prostate cancer (2002)
    Melbourne, Australia : Blackwell Science Pty
    International journal of urology 9 (2002), S. 0 
    Details
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Lack of androgen receptor (AR) expression or mutation on the AR gene creates the tendency for androgen independence and progression of prostate cancer. However, the association between the progression and AR expression or mutations is still controversial. In this study, we evaluated the prognostic significance of AR expression and mutations in prostate cancers.Methods: Forty-two prostate adenocarcinomas and three lymph node metastatic lesions sampled prior to hormonal therapy were included in this study; AR expression was analyzed immunohistochemically using an antibody against AR and the result was scored as the percentage of AR-positive tumor cells in the total tumor cells. Polymerase chain reaction–single-strand conformational polymorphism (PCR-SSCP) analysis and DNA sequencing were used to detect AR mutations.Results: Our study revealed the average AR expression in the prostate adenocarcinoma was 52.2 ± 27.1%, which was significantly lower than that in the adjacent non-tumorous prostate tissue (68.3 ± 18.3% in average) (P 〈 0.001). A significant correlation was obtained between progression-free survival and AR expression (P 〈 0.01). By SSCP analysis, three silent mutations (T649T, E709E and E711E) were detected in three separate prostate carcinomas.Conclusion : We conclude that AR expression is a useful prognostic indicator for tumor progression. Androgen receptor mutation may be an uncommon molecular event in untreated prostate cancer in Japanese men.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1442-2042.2002.00514.x
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  • 2
    Electronic Resource
    Electronic Resource
    Mobile fat; three stages? (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Australasian journal of dermatology 37 (1996), S. 0 
    Details
    ISSN: 1440-0960
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-0960.1996.tb01063.x
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  • 3
    Electronic Resource
    Electronic Resource
    Nodular lymphoid hyperplasia of the terminal ileum: Report of a case and the findings of an immunological analysis (1996)
    Springer
    Surgery today 26 (1996), S. 431-434 
    Details
    ISSN: 1436-2813
    Keywords: nodular lymphoid hyperplasia ; ileum ; humoral immunity ; immunohistochemical staining
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The immunological and immunohistochemical characteristics of a patient with nodular lymphoid hyperplasia (NLH) of the terminal ileum were investigated pre- and post-operatively. The patient presented with diarrhea, lower abdominal pain, and weight loss, and an abdominal X-ray following barium enema revealed multiple small nodules in the terminal ileum which were subsequently confirmed to be NLH by histological examination. Preoperatively, although the serum immunoglobulin levels were normal, the T-cell responses in the peripheral blood, including the phytohemagglutinin (PHA)-blastogenesis and the T4/T8 ratio, were impaired. However, following an ileocecal resection, the PHA-blastogenesis became augmented and the T4/T8 ratio recovered to within the normal range. The immunohistochemical findings revealed a more marked accumulation of T cells in the interstitium around the hyperplastic follicles than in the interstitium of the normal intestine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311931
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of ipriflavone on calcitonin synthesis in c cells of the rat thyroid (1992)
    Springer
    Calcified tissue international 51 (1992), S. S27 
    Details
    ISSN: 1432-0827
    Keywords: Ipriflavone ; Calcitonin ; Estrone ; Bone resorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Ipriflavone is known to stimulate calcitonin (CT) secretion from the thyroid glands of female animals, but the exact mechanism of this action remains unknown. In the present study, an increase of CT production in thyroid C cells of female rats, but not of male rats, was proven immunohistochemically. Furthermore, the parallel increase of CT mRNA in those thyroid glands was confirmed by Northern blot analysis. These results proved that ipriflavone stimulates not only CT secretion but also CT synthesis in thyroid C cells and that the changes were gender dependent (greater in females). In order to investigate the effect of estrogen on the ipriflavone-induced increase of CT in female rat thyroid gland, CT and CT mRNA in the thyroid glands of untreated, ovariectomized, and estrone-treated (postovariectomy) rats were examined by both immunohistochemistry and Northern blot technique. Serum levels of CT and calcium were also examined. Against expectation, estrone failed to produce any significant effect on the ability of ipriflavone to induce CT synthesis and secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02180246
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  • 5
    Electronic Resource
    Electronic Resource
    Comparative analysis of clonality and pathology in primary and secondary hyperparathyroidism (1997)
    Springer
    Virchows Archiv 430 (1997), S. 247-251 
    Details
    ISSN: 1432-2307
    Keywords: Parathyroid ; Hyperparathyroidism ; Clonality ; PGK-1 gene ; Pathology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Parathyroid adenoma and hyperplasia are the most common causes for hyperparathyroidism, and distinction between them is controversial based on the current criteria for pathological diagnosis. We studied the clonality of hyperparathyroidism and its correlation with the pathological features, analysing 39 female patients with hyperparathyroidism. Clonality was successfully detected in 12 heterozygous cases by PCR amplification ofPGK-1 gene. The 12 cases yielded 14 hypercellular glands, 8 affected by primary and 6 by secondary hyperparathyroidism. The results revealed that 7 of the 8 glands with primary hyperparathyroidism showed monoclonal proliferation. Only 1 gland pathologically diagnosed as adenoma showed a polyclonal pattern. In the 4 cases with secondary hyperparathyroidism, at least one monoclonal tumour was detected in each case. Our data indicate that monoclonal tumours are more common than expected in both primary and secondary hyperparathyroidism. Monoclonal tumours and polyclonal hyperplasia can co-exist in the same patient. Comparative study of the clonality and the pathological features showed that the clonality was consistent with the diagnosis of parathyroid adenoma, whereas it was in conflict with the diagnosis of hyperplasia with multigland involvement. One of the reasons for this is that we are ignorant of the true natures of hyperparathyroidism with multigland involvement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01324809
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  • 6
    Electronic Resource
    Electronic Resource
    Pearson's marrow/pancreas syndrome: A histological and genetic study (1993)
    Springer
    Virchows Archiv 423 (1993), S. 227-231 
    Details
    ISSN: 1432-2307
    Keywords: Pearson's syndrome ; Mitochondrial DNA ; Diabetes mellitus ; Ragged-red fibre
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A patient with features of Pearson's syndrome who presented with transfusion-dependent severe macrocytic anaemia, neutropoenia, thrombocytopoenia, and insulin-dependent diabetes mellitus in the neonatal period is described. His bone marrow was characterized by marked vacuolization of myeloid precursors and ringed sideroblasts. Autopsy examination revealed fibrosis and steatosis of the liver, reduction in the size and number of the islets, fibrosis and acinar atrophy of the pancreas, vacuolation of renal tubules, glomerulosclerosis, and “ragged red” fibres of skeletal muscles. Analysis of mitochondrial DNA (mtDNA) from the autopsied liver and skeletal muscle showed mtDNA heteroplasmy in both tissues, with one population of mtDNA deleted by 7374 bp. The deleted region was bridged by a single nucleotide, C, in normal mtDNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01614775
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  • 7
    Electronic Resource
    Electronic Resource
    Ultrastructural study of poorly differentiated medullary carcinoma of the thyroid (1987)
    Springer
    Virchows Archiv 410 (1987), S. 455-460 
    Details
    ISSN: 1432-2307
    Keywords: Thyroid neoplasms ; Ultrastructure prognosis ; C cell ; Calcitonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Five cases of sporadic medullary carcinoma of the thyroid (MTC) with rapidly progressive disease were studied ultrastructurally. The tumour cells had poorly differentiated C cell characteristics. They exhibited smaller secretory granules in their narrow cytoplasm. Morphometric analysis disclosed that the average diameter of the secretory granules of the cases with a poor prognosis was 173.0 nm in comparison with 254.2 nm of well differentiated cases. The granules were fewer in the poor prognostic group (1.31/µ2) than the well differentiated group (2.75/µ2). Increased free ribosomes and polysomes were noted in the cytoplasm and dispersed chromatin in the nuclei. These cases should be therefore classified as poorly differentiated MTC rather than atypical or anaplastic MTC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00712766
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  • 8
    Electronic Resource
    Electronic Resource
    An autopsy case of a cystic variant of thymic carcinoma mimicking a thymic cyst (1990)
    Springer
    Virchows Archiv 417 (1990), S. 85-87 
    Details
    ISSN: 1432-2307
    Keywords: Thymic carcinoma ; Thymic cyst ; Autopsy ; Metastasis ; Goblet cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An autopsy case of thymic carcinoma is reported. The surgically excised cystic tumour from a 38-year-old Japanese male mimicked a thymic cyst pathologically. After a clinical course of 6 years, postmortem examination disclosed extensive metastases, including cystic lesions lined by benign-loocking squamous epithelium. This evidence suggested that the present tumour was one of the specific variants of thymic carcinoma and not a thymic cyst with malignant transformation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01600114
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  • 9
    Electronic Resource
    Electronic Resource
    Allelic variants of human calcitonin receptor in the Japanese population (1996)
    Springer
    Human genetics 〈Berlin〉 99 (1996), S. 38-41 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Evidence from cDNA cloning has shown that calcitonin receptors (CTRs) have seven potential transmembrane domains. In this study, structural analysis of CTRs from ten cultured human tumor cell lines and 117 human blood samples demonstrated allelic variants at the 1377th nucleotide in intracellular domain 4, expressing either proline or leucine as the 463rd amino acid. It was found that the variant with proline at this site was the more prevalent type of CTR among the Japanese population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050307
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  • 10
    Electronic Resource
    Electronic Resource
    Somatostatin-like immunoreactivity in rat thyroid (1984)
    Springer
    Cell & tissue research 238 (1984), S. 661-663 
    Details
    ISSN: 1432-0878
    Keywords: Thyroid glands ; Thyroid neoplasms ; Aging ; Calcitonin ; Somatostatin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Somatostatin-like immunoreactive cells of the rat thyroid gland at various ages were investigated immunohistochemically. The number of cells per lobe in 5 μm sections increased with age. Immunopositive cells were evident as small clusters in the older age group (8 to 24 months old) but not clustered in the younger age group (3 to 5 months old). This type of proliferation was termed S-cell hyperplasia in a manner similar to C-cell hyperplasia observed in the aged rat thyroid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219887
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