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  • 1
    Electronic Resource
    Electronic Resource
    Allelic variants of human calcitonin receptor in the Japanese population (1996)
    Springer
    Human genetics 〈Berlin〉 99 (1996), S. 38-41 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Evidence from cDNA cloning has shown that calcitonin receptors (CTRs) have seven potential transmembrane domains. In this study, structural analysis of CTRs from ten cultured human tumor cell lines and 117 human blood samples demonstrated allelic variants at the 1377th nucleotide in intracellular domain 4, expressing either proline or leucine as the 463rd amino acid. It was found that the variant with proline at this site was the more prevalent type of CTR among the Japanese population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050307
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  • 2
    Electronic Resource
    Electronic Resource
    Research on Product Development Process Management for Virtual Enterprise (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Applied mechanics and materials Vol. 10-12 (Dec. 2007), p. 838-841 
    Details
    ISSN: 1662-7482
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: For a manufacturing enterprise to be competitive in constantly changing marketenvironment, it is necessary to adopt a new model called agile manufacturing by organizing VirtualEnterprise. Aimed at developing a product development process management (PDPM) system forVirtual Enterprise, modeling of product development process is discussed and a union informationmodel is proposed using Object Modeling Technique. Based on the J2EE platform, a framework ofPDPM system is built up with a three-tiered architecture, which consists of several EnterpriseJavaBeans components to ensure compatibility, distribution, and flexibility of the system. A PDPMsystem prototype is developed utilizing JAVA and has been validated in a simulated virtualenterprise environment
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/38/transtech_doi~10.4028%252Fwww.scientific.net%252FAMM.10-12.838.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Expression and somatic mutation on androgen receptor gene in prostate cancer (2002)
    Melbourne, Australia : Blackwell Science Pty
    International journal of urology 9 (2002), S. 0 
    Details
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Lack of androgen receptor (AR) expression or mutation on the AR gene creates the tendency for androgen independence and progression of prostate cancer. However, the association between the progression and AR expression or mutations is still controversial. In this study, we evaluated the prognostic significance of AR expression and mutations in prostate cancers.Methods: Forty-two prostate adenocarcinomas and three lymph node metastatic lesions sampled prior to hormonal therapy were included in this study; AR expression was analyzed immunohistochemically using an antibody against AR and the result was scored as the percentage of AR-positive tumor cells in the total tumor cells. Polymerase chain reaction–single-strand conformational polymorphism (PCR-SSCP) analysis and DNA sequencing were used to detect AR mutations.Results: Our study revealed the average AR expression in the prostate adenocarcinoma was 52.2 ± 27.1%, which was significantly lower than that in the adjacent non-tumorous prostate tissue (68.3 ± 18.3% in average) (P 〈 0.001). A significant correlation was obtained between progression-free survival and AR expression (P 〈 0.01). By SSCP analysis, three silent mutations (T649T, E709E and E711E) were detected in three separate prostate carcinomas.Conclusion : We conclude that AR expression is a useful prognostic indicator for tumor progression. Androgen receptor mutation may be an uncommon molecular event in untreated prostate cancer in Japanese men.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1442-2042.2002.00514.x
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of finite temporal duration on spatial solitons in a planar optical waveguide (1995)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 67 (1995), S. 2774-2776 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The effects of finite temporal duration on the spatial solitons in a planar optical waveguide are analyzed. The results show that (i) the self-trapped pulses with finite temporal duration are unstable and collapse at higher peak power in a planar optical waveguide with the anomalous group velocity dispersion (GVD), but the collapse does not occur in a planar optical waveguide with the normal GVD; (ii) the spatial soliton with finite temporal duration has a transverse velocity which is proportional to the spatial width and inversely proportional to the temporal duration of the soliton, and the bright spatiotemporal solitons do not form multiple soliton bound states; and (iii) the peak power required for self-trapping of the pulse in a planar optical waveguide with the normal GVD is less than the critical peak power for collapse of the pulses in a planar optical waveguide with the anomalous GVD. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.114589
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  • 5
    Electronic Resource
    Electronic Resource
    (2+1)-dimensional fundamental spatial dark soliton (1995)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 66 (1995), S. 665-666 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We give the analytical fundamental dark soliton solutions of the (2+1)-dimensional nonlinear Schrodinger equation [(2+1)-D NSE]. The solutions reduce to (1+1)-D dark soliton solutions when the width of soliton in one transverse direction is much wider than that in the other direction, which is in good agreement with the experimental observation of the dark spatial solitons. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.114092
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  • 6
    Electronic Resource
    Electronic Resource
    Comparative analysis of clonality and pathology in primary and secondary hyperparathyroidism (1997)
    Springer
    Virchows Archiv 430 (1997), S. 247-251 
    Details
    ISSN: 1432-2307
    Keywords: Parathyroid ; Hyperparathyroidism ; Clonality ; PGK-1 gene ; Pathology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Parathyroid adenoma and hyperplasia are the most common causes for hyperparathyroidism, and distinction between them is controversial based on the current criteria for pathological diagnosis. We studied the clonality of hyperparathyroidism and its correlation with the pathological features, analysing 39 female patients with hyperparathyroidism. Clonality was successfully detected in 12 heterozygous cases by PCR amplification ofPGK-1 gene. The 12 cases yielded 14 hypercellular glands, 8 affected by primary and 6 by secondary hyperparathyroidism. The results revealed that 7 of the 8 glands with primary hyperparathyroidism showed monoclonal proliferation. Only 1 gland pathologically diagnosed as adenoma showed a polyclonal pattern. In the 4 cases with secondary hyperparathyroidism, at least one monoclonal tumour was detected in each case. Our data indicate that monoclonal tumours are more common than expected in both primary and secondary hyperparathyroidism. Monoclonal tumours and polyclonal hyperplasia can co-exist in the same patient. Comparative study of the clonality and the pathological features showed that the clonality was consistent with the diagnosis of parathyroid adenoma, whereas it was in conflict with the diagnosis of hyperplasia with multigland involvement. One of the reasons for this is that we are ignorant of the true natures of hyperparathyroidism with multigland involvement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01324809
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  • 7
    Electronic Resource
    Electronic Resource
    Expression of Bcl-2 but not Bax or p53 correlates with in vitro resistance to a series of anticancer drugs in breast carcinoma (2000)
    Springer
    Breast cancer research and treatment 61 (2000), S. 211-216 
    Details
    ISSN: 1573-7217
    Keywords: Bcl-2 ; breast cancer ; chemosensitivity ; HDRA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Programmed cell death is an important determinant of the response to chemotherapy. Among the factors controlling this process, a significant role is played by bcl-2, bax and p53. The in vitro chemosensitivity of the 177 breast carcinomas was assessed by the histoculture drug response assay (HDRA) using mitomycin C (MMC), 5-fluorouracil (5-Fu), adriamycin (ADM), cisplatin (CDDP), and cyclophosphamide (CPA). The susceptibility of Bcl-2-negative tumors to all the drugs killing was significantly higher than that of Bcl-2-positive tumors. No relationship between Bax or p53 immunoreactivity and sensitivity for any of anticancer drugs studied was demonstrated. Immunohistochemical results regarding Bcl-2 are promising in the evaluation of the sensitivity of cancer cells to a series of anticancer drugs and might be therapeutically useful as an indicator of response to adjuvant chemotherapy for breast cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006474307180
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