Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Monatsschrift Kinderheilkunde 145 (1997), S. 1156-1162 
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Münchhausen-by-proxy-Syndrom ; Kindesmißhandlung ; Artifizielle Krankheiten ; Rechtsmedizin ; Key words Munchausen by proxy syndrome ; Child abuse ; Artificial illness ; Legal authorities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The diagnosis of Munchausen by proxy syndrome, a subtle form of child abuse, is very difficult. One reason is a seemingly well caring ”ideal” mother who is mainly responsible for the fabricated illness of her child, the other biologically and technically well trained medical doctors maltreating the children unwittingly. Doctors are often separated from each other by their subspecialities but nevertheless directly approached by the mothers. The latter frequently have a medical education. A warning list of ″red flags″ of symptoms and clinical situations should sensitise the pediatrician for artificial illnesses and enable him to start diagnostic work-up early. One responsible doctor should coordinate all activities. The crucial step is a separation of mother and child, but a team approach involving child psychiatry, child wellfare organisations and legal authorities is mandatory. Therapeutic options for the perpetrators are minimal. The prognosis is poor if such a child is not separated from his family or retransferred too early. Research to understand psychopathology and to develop new therapeutic options is needed.
    Notes: Zusammenfassung Das Münchhausen-by-proxy-Syndrom ist eine subtile Form der Kindesmißhandlung. Die Diagnose ist äußerst schwierig. Das liegt zum einen an den oberflächlich betrachtet fürsorglichen Eltern und andererseits an den biologisch-technisch ausgerichteten Medizinern, die entscheidend, aber unwissentlich lange Mitmißhandler sind. Letztere verteilen sich auf viele, miteinander zu wenig kommunizierende Fachdisziplinen und werden oft direkt von den Patienten kontaktiert. Die Erfindung glaubhafter medizinischer Symptome durch die meistens verantwortlichen Mütter beruht oft auf einer eigenen „medizinischen Ausbildung” und/oder in der zunehmenden Medizinalisierung der breiten Öffentlichkeit. Eine Warnliste an Symptomen und Konstellationen sollte den Haus- oder Kinderarzt für artifizielle Krankheiten sensibilisieren, um möglichst früh erste diagnostische Schritte einzuleiten. Es ist entscheidend, daß ein verantwortlicher Kinderarzt die Initiative ergreift und die Fäden in der Hand behält. Die beweisende Diagnose ist oft nur im Team in Zusammenarbeit mit Kinderpsychiatrie, Pädagogik, Justiz und Jugendbehörden möglich und erfordert die Trennung von Mutter und Kind. Erfolgreiche therapeutische Ansätze für die Täter existieren nur vereinzelt. Bei fehlender Trennung von der Familie oder zu frühem Retransfer ist die Prognose für die mißhandelten Kinder sehr ungünstig. Ein wissenschaftstheoretischer Ansatz zum besseren Verständnis der Psychopathologie und zur Entwicklung neuer therapeutischer Alternativen ist erforderlich.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Monatsschrift Kinderheilkunde 145 (1997), S. 470-472 
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Bakterielle Dünndarmüberwucherung ; Gedeihstörung ; H2-Atemtest ; Darmresektion ; Morbus Hirschsprung ; Key words Small bowel bacterial overgrowth ; Failure to thrive ; Breath hydrogen test ; Small bowel resection ; Hirsprungs's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Evaluation of three patients, aged between three months and five years because of failure to thrive and persistent diarrhea revealed the diagnosis of small bowel bacterial overgrowth. A combination of a typical history, endoscopy, laboratory, radiological and histological methods as well as the breath hydrogen test were used. All patients had preexisting intestinal disease: two (former premature infants) had been operated several times because of necrotizing enterocolitis including resection of larger parts of small bowel. The third patient was suffering from pancolonic Hirschsprung's disease. All patients gained weight and reported less complaints after antibiotic treatment with metronidazole. Discussion: Small bowel bacterial overgrowth has to be considered in the differential diagnosis of failure to thrive, especially in cases with preexisting intestinal disease. The diagnosis may be substantiated by a combination of indirect methods. Direct bacteriologic analysis is difficult. Usually, antibiotic treatment leads to a good weight gain after a short period of time.
    Notes: Zusammenfassung Bei 3 Patienten im Alter von 3 Monaten bis 5 Jahren, die zur Abklärung einer Gedeihstörung und rezidivierender Durchfälle vorgestellt wurden, konnte mittels einer Kombination von typischer Anamnese, laborchemischer, radiologischer, endoskopischer und histologischer Methoden und des H2-Atemtests die Diagnose einer bakteriellen Dünndarmüberwucherung gestellt werden. Von besonderer Bedeutung ist, daß bei allen Patienten eine Darmerkrankung vorbestand: Zwei Patienten, ehemalige Frühgeborene, waren im Rahmen einer nekrotisierenden Enterokolitis mehrfach laparotomiert worden, es bestand die Notwendigkeit zu teilweise ausgedehnten Darmresektionen. Beim 3. Patienten wurde ein langstreckiger Morbus Hirschsprung gesichert. Eine antibiotische Therapie mit Metronidazol führte in allen 3 Fällen zu einer Gewichtszunahme und Besserung der klinischen Beschwerden. Diskussion: Die bakterielle Dünndarmüberwucherung ist eine wichtige Differentialdiagnose der Gedeihstörung, insbesondere bei vorbestehender Darmerkrankung. Die Diagnose ergibt sich aus der Kombination verschiedener indirekter Untersuchungsverfahren. Ein direkter mikrobiologischer Nachweis ist schwierig. Eine antibiotische Therapie führt in der Regel zur raschen Gewichtszunahme.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 3 (1988), S. 312-317 
    ISSN: 1437-9813
    Keywords: Short bowel syndrome ; Total parenteral nutrition (TPN) ; Home-TPN ; Oral nutrition ; Adaptive growth
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Adequate oral nutrition in patients with short bowel syndrome after operation is limited by the amount of intestine left after resection. The remnant small intestine has an important capacity to compensate for the loss of mucosal tissue and develops intestinal hyperplasia when stimulated by a variety of luminal and extraluminal factors such as nutrients, pancreatic biliary secretions, growth factors and hormones. In order to provide appropriate stimuli for the intestinal adaptation after resection, oral feeding is necessary as early as possible after operation. Among nutrients fat, especially LCT and free fatty acids, are the most stimulating nutrients besides proteins and carbohydrates. They increase pancreatic biliary secretions and the excretion of growth promoting hormones such as enteroglucagon. Because of gastric acid hypersecretion the administration of H2 receptor blocking agents (cimetidine) is recommended in these patients. As oral caloric intake is not sufficient in most patients with short bowel syndrome after operation total parenteral nutrition (TPN) or home-TPN has to be installed for longer periods to supplement the appropriate nutritional needs. Both early oral feeding together with TPN or home-TPN have increased considerably the survival rate of children with short bowel syndrome.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1432-1238
    Keywords: Key words Enteral nutrition ; Critical illness ; Prokinetic drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To investigate the influence of the prokinetic drug cisapride on gastrocaecal transit time (GCTT) in children after open heart surgery. Design: Prospective, randomized and controlled study. Setting: Interdisciplinary paediatric intensive care unit in a tertiary-care children‘s hospital. Patient: Twenty-one children with a median age of 6.2 years on day 1 after uncomplicated open heart surgery for isolated septal defects, acquired mitral or aortic valve disease or tetralogy of Fallot. Control group consisting of 10 healthy children with a median age of 8.1 years. Interventions: Ten children were randomized to receive cisapride 0.2 mg/kg body weight, 30 min prior to measurement of GCTT. Measurements and results: GCTT was measured using hydrogen breath testing with a test solution containing lactulose and mannitol (0.4 g/kg and 0.1 g/kg body weight respectively). GCTT was markedly delayed in all patients compared to the control group. Within 8 h 8/10 patients in the treatment group versus 4/11 patients in the non-cisapride group achieved gastrocaecal transit. No adverse side-effects were observed. Conclusions: Cisapride accelerates gastrocaecal transit after open heart surgery in children. In intensive care patients on inotropic support or opioid medication, it may facilitate the earlier reintroduction of enteral feeding.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1432-1238
    Keywords: Enteral nutrition ; Critical illness ; Prokinetic drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To investigate the influence of the prokinetic drug cisapride on gastrocaecal transit time (GCTT) in children after open heart surgery. Design Prospective, randomized and controlled study. Setting Interdisciplinary paediatric intensive care unit in a tertiary-care children's hospital. Patient Twenty-one children with a median age of 6.2 years on day 1 after uncomplicated open heart surgery for isolated septal defects, acquired mitral or aortic valve disease or tetralogy of Fallot. Control group consisting of 10 healthy children with a median age of 8.1 years. Interventions Ten children were randomized to receive cisapride 0.2 mg/kg body weight, 30 min prior to measurement of GCTT. Measurements and results GCTT was measured using hydrogen breath testing with a test solution containing lactulose and mannitol (0.4 g/kg and 0.1 g/kg body weight respectively). GCTT was markedly delayed in all patients compared to the control group. Within 8 h 8/10 patients in the treatment group versus 4/11 patients in the noncisapride group achieved gastrocaecal transit. No adverse side-effects were observed. Conclusions Cisapride accelerates gastrocaecal transit after open heart surgery in children. In intensive care patients on inotropic support or opioid medication, it may facilitate the earlier reintroduction of enteral feeding.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The geographic distribution and origin of CFTR mutations in Germany was evaluated in 658 three-generation families with cystic fibrosis (CF). Fifty different mutations were detected on 1305 parental CF chromosomes from 22 European countries and overseas. The major mutation ΔF508 was identified on 71.5% of all CF chromosomes, followed by R553X (1.8%), N1303K (1.3%), G542X (1.1%), G551D (0.8%) and R347P (0.8%). According to the grandparents’ birthplace, 74% of CF chromosomes had their origin in Germany; the ΔF508 percentage was 77%, 75%, 70% and 62% in northern, southern, western and eastern Germany, respectively. Ten or more mutant alleles in the investigated CF gene pool originated from Austria, the Czech Republic, Poland, Russia, Turkey and the Ukraine. This widespread geographic origin of CFTR mutations in today’s Germany reflects the many demographic changes and migrations in Central Europe during the 20th century.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The geographic distribution and origin of CFTR mutations in Germany was evaluated in 658 three-generation families with cystic fibrosis (CF). Fifty different mutations were detected on 1305 parental CF chromosomes from 22 European countries and overseas. The major mutation ΔF508 was identified on 71.5% of all CF chromosomes, followed by R553X (1.8%), N1303K (1.3%), G542X (1.1%), G551D (0.8%) and R347P (0.8%). According to the grandparents' birthplace, 74% of CF chromosomes had their origin in Germany; the ΔF508 percentage was 77%, 75%, 70% and 62% in northern, southern, western and eastern Germany, respectively. Ten or more mutant alleles in the investigated CF gene pool originated from Austria, the Czech Republic, Poland, Russia, Turkey and the Ukraine. This widespread geographic origin of CFTR mutations in today's Germany reflects the many demographic changes and migrations in Central Europe during the 20th century.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 145 (1986), S. 570-571 
    ISSN: 1432-1076
    Keywords: Alimentary vitamin B12 deficiency ; Vegetarianism ; Megaloblastic anaemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Megaloblastic anaemia in infancy is uncommon in western countries. We describe a case of an exclusively breast-fed monozygous twin with severe vitamin B12 deficiency with haematologic and neurologic abnormalities. Treatment with vitamin B12 resulted in a rapid haematological and clinical improvement.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 148 (1989), S. 294-299 
    ISSN: 1432-1076
    Keywords: Short bowel syndrome ; Intestinal adaptation ; Trophic substances
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract After massive resection of the small intestine the remannt mucosa has an important capacity to enlarge the absorptive surface for the digestion, hydrolysis and absorption of nutrients. This intestinal adaptation is achieved by the interaction of various factors. Oral nutrients together with pancreatic biliary secretions stimulate the mucosa to become hyperplastic. Secondary to these luminal factors hormones play an important role in the adaptive process. Among the hormones, enteroglucagon is the most important growth promoting agent together with other growth factors such as epidermal growth factor, prostaglandin E2 and human growth hormone analogues, e.g. plerocercoid growth factor from the plerocercoid larvae of the tapeworm Spirometra mansonoides. The intestinal enterocyte is the target of these factors and within the cell the synthesis of polyamines, which are responsible for rapid growth, is the most essential step for the development of hyperplasia after resection. The rate limiting enzyme for polyamine synthesis ornithine decarboxylase (ODC) reacts to trophic stimuli with an increased activity. Thereafter rapid accumulation of tissue polyamines occurs. Blockade of ODC by specific inhibitors is accompanied by absence of intestinal hyperplasia after resection. Therefore it is concluded that ODC plays a key role in the intestinal adaptation of the remnant small bowel. To start and enhance intestinal hyperplasia after resection in patients with short bowel syndrome introduction of oral nutrition as soon as possible after operation is very important. On account of gastric acid hypersecretion the use of H2 receptor blocking agents is recommended. A decreased intestinal transit time is treated with loperamide. Adequate nutritional support by enteral and (home) parenteral feeding is the prerequisite for the initiation and development of intestinal adaption in short bowel syndrome.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 1432-1076
    Keywords: Diagnostic value ; Gliadin IgG, IgA, and IgE antibody determinations ; Coeliac disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The diagnostic value of gliadin IgG, IgA and IgE antibody (AB) determinations using the fluorescent immunosorbent test was examined in 586 children with malabsorptive disorders and/or failure to thrive. All patients underwent jejunal biopsy and were on a gluten-containing diet. IgG AB were found in all patients (331/331) with untreated coeliac disease (CD) in our study, but IgA AB in only 295/331 (89%). Therefore a screening test based only on IgA AB determinations is not recommended. By contrast, 203 (80%) of 255 children with other malabsorptive disorders had no gliadin AB, 43 (16.5%) had only IgG AB and only 9 (3.5%) had IgG and IgA AB. IgE AB proved to be of no additional value as a diagnostic tool because they were found in a quarter of the children without CD. Statistical evaluation of combined IgG and IgA AB determination showed at least 96% sensitivity and a specificity of 97%. The subjective (“Bayesian”) probability that an actual patient with a given AB test result has CD, is considered: a patient very probably has CD in the case of positive IgG and IgA AB, and no CD in the case of a negative AB result. In the case of negative IgA AB but positive IgG AB the physician's judgement (“prior probability”) influences the (“posterior”) probability of CD for an actual patient. In contrast to IgG AB, IgA AB decline rapidly after the introduction of a gluten-free diet and may be used for diet control after diagnosis. Antibodies against cow's milk proteins, though present in 72% of the 331 patients with CD, are of no therapeutic significance in CD and are of no value for its diagnosis.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...