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  • 1
    Electronic Resource
    Electronic Resource
    Effectiveness of the newly synthesized cardiotonic agent (TA-064) in diseased hearts with normal and diminished parameters of contractility
    Amsterdam : Elsevier
    Journal of Molecular and Cellular Cardiology 16 (1984), S. 42 
    Details
    ISSN: 0022-2828
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0022-2828(84)80481-2
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  • 2
    Electronic Resource
    Electronic Resource
    Preliminary experiments for the study of the interplanetary medium by the release of metal vapour in the upper atmosphere
    Amsterdam : Elsevier
    Planetary and Space Science 13 (1965), S. 95-114 
    Details
    ISSN: 0032-0633
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0032-0633(65)90180-7
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  • 3
    Electronic Resource
    Electronic Resource
    Artificial strontium and barium clouds in the upper atmosphere
    Amsterdam : Elsevier
    Planetary and Space Science 15 (1967), S. 357-372 
    Details
    ISSN: 0032-0633
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0032-0633(67)90200-0
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  • 4
    Electronic Resource
    Electronic Resource
    Functional properties of mahaim fibers (1977)
    Springer
    Journal of molecular medicine 55 (1977), S. 1031-1037 
    Details
    ISSN: 1432-1440
    Keywords: Mahaim-Leitung ; Supranormale Phase der A-V-Überleitung ; Refraktärperioden ; Re-entry Bahn ; Mahaim Fiber conduction ; Supernormal phase of A-V-conduction ; Refractory periods ; Re-entry pathway
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Electrophysiological studies were performed in a patient with a short P-R interval and a small delta wave. The findings suggest that ventricular pre-excitation resulted from an infranodal bypass (Mahaim type). As the functional properties of the pathway were evaluated, impaired conductivity (suggested by rather long refractory periods) became apparent at frequency stress. The pathway could easily be blocked by Ajmaline. This demonstrated an unexpected early diastolic improvement in conductivity; i.e. a supernormal phase of conduction. Due to this supernormal phase, Mahaim-fiber conduction was present when block in the anterior division of the left bundle branch, or even trifasicular block occurred. Thus the effects of exclusive Mahaim-fiber conduction on ventricular activation were documented.
    Notes: Zusammenfassung Es wird über die Ergebnisse einer elektrophysiologischen Untersuchung eines Patienten mit kurzer PQ-Zeit und diskreter Delta-Welle berichtet. Die Befunde sprechen dafür, daß die Präexcitation des Ventrikelmyokards über einen infranodalen Bypass zustande kam (Mahaim Typ). Lange Refraktärzeiten, frühzeitige Blockierung bei Frequenzbelastung und Block der akzessorischen Bahn nach einer niedrigen Ajmalindosis sprachen für eine instabile Leitung in dieser Struktur. Zusätzlich wurde eine überraschende frühdiastolische Wiederherstellung der Leitfähigkeit der Mahaim Bahn — eine supranormale Phase der Erregungsleitung — nachgewiesen. Während dieser Phase der supranormalen Erregungsleitung der Mahaim Bahn traten Blockierungen im normalen intraventrikulären Erregungsleitungssystem auf, so daß die Beeinflussung der QRS-Morphologie bei erhaltener Mahaim Leitung und gleichzeitiger Blockierung im anterioren Faszikel des linken Schenkels oder gleichartigem Block des linken Schenkels oder gar trifaszikulärem Block dokumentiert werden konnte.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01489476
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  • 5
    Electronic Resource
    Electronic Resource
    The AMPTE artificial comet experiments (1986)
    [s.l.] : Nature Publishing Group
    Nature 320 (1986), S. 700-703 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In July last year and in December 1984, barium clouds were injected into the solar wind from the AMPTE satellite. The clouds resembled those of natural comets in that a head and tail were clearly visible. Tail rays formed with speeds of a few tens of kilometres per second, and other structures ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/320700a0
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  • 6
    Electronic Resource
    Electronic Resource
    Neopterin im Serum und Urin zur Differentialdiagnose von Nierenfunktionsstörungen nach Nierentransplantation (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 225-231 
    Details
    ISSN: 1432-1440
    Keywords: Neopterin ; Renal transplantation ; Allograft rejection ; Infection ; Cyclosporin A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a period of 10 months neopterin in serum and urine was determined by radioimmunoassay in 33 renal allograft recipients treated with cyclosporin A. While in allograft rejections the highest neopterin concentrations were found in the serum, patients with viral infections after renal transplantation showed the most elevated concentrations in the urine. For early diagnosis of allograft rejection the ratio of neopterin clearance and serum-neopterin was the most significant criterion of the parameters measured in this study. Patients without complications during the follow-up showed slightly elevated and stable neopterin levels in serum and urine. The presented results indicate that neopterin is a useful parameter for the follow-up after renal allograft transplantation and for the diagnosis of immunological complications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01715851
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  • 7
    Electronic Resource
    Electronic Resource
    The vasopressor system in patients with heart failure due to idiopathic dilated cardiomyopathy-influence of the clinical stage of disease and of chronic drug treatment (1989)
    Springer
    Cardiovascular drugs and therapy 3 (1989), S. 771-778 
    Details
    ISSN: 1573-7241
    Keywords: dilated cardiomyopathy ; vasoconstriction system ; plasma volume ; congestive heart failure ; catecholamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Alterations in the vasopressor system found in cardiac failure are part of compensatory measures that may modify pharmacologic-therapeutic response. Therefore, in 64 patients with dilated cardiomyopathy, we investigated its enhanced activity in different clinical stages of the disease as compared to normal controls. Patients in NYHA class II (n=20) demonstrated increased activity of the sympathico-adrenal, reninangiotensin-aldosterone, vasopressin, and atrial natriueretic factor systems, while maximum values were found in patients of NYHA class IV (n=24). In these patients, noradrenaline was enhanced by a factor of 7, adrenaline by a factor of 2, plasma-renin-activity by a factor of 7, angiotensin II by a factor of 2.5, aldosterone by a factor of 5, vasopressin by a factor of 1.5, and ANF by a factor of 4 as compared to normal controls Clinical NYHA classes correlated to a certain degree with the various plasma hormones. Patients treated with an aldosterone inhibitor in addition to digitalis and diuretics revealed significantly higher values for aldosterone, vasopressin, and angiotensin II as compared to those who received digitalis and diuretics alone. The addition of ACE-inhibitor therapy resulted in a decrease of angiotensin II, aldosterone, and vasopressin. Plasma catecholamines and ANF, however, did not change under the influence of cardiac medication. Diuretic treatment in NYHA class II patients reduced plasma volumes (p〈0.01). Plasma volume in NYHA class IV patients only was found to be higher than in normal controls. Thus, analysis of the neurohumoral system can aid both in the identification of the clinical degree of dilated cardiomyopathy and in its optimal therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01857630
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  • 8
    Electronic Resource
    Electronic Resource
    Heterodromia in accessory A-V connections (1975)
    Springer
    Basic research in cardiology 70 (1975), S. 364-376 
    Details
    ISSN: 1435-1803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 15 Patienten mit WPW-Syndrom wurde über die Ableitung intrakardialer Elektrogramme das Verhalten der atrio-ventrikulären und ventrikulo-atrialen Leitung bei atrialer und ventrikulärer Stimulation untersucht. Durch den Vergleich typischer Verhaltensmuster der normalen und akzessorischen Bahn konnte wahrscheinlich gemacht werden, daß bei 13 Patienten die V-A-Leitung über die akzessorische Bahn erfolgt. Entsprechend dem Verhalten der Vorwärts-und Rückwärtsleitung unter Frequenzbelastung konnten drei Gruppen mit je 5 Patienten unterschieden werden. Gruppe I: gute akzessorische A-V- und V-A-Leitung. Gruppe II: gute akzessorische A-V-Leitung bei schlechter V-A-Leitung. Gruppe III: schlechte akzessorische A-V-Leitung bei guter V-A-Leitung. Bei Gruppe I wurde noch die Beeinflussung der akzessorischen A-V- und V-A-Leitung durch Ajmalin geprüft. Die in Gruppe II und III ausgeprägte Heterodromie der akzessorischen Bahn sowie die unterschiedliche Beeinflußbarkeit der akzessorischen A-V- und V-A-Leitung durch Ajmalin werden über elektrophysiologische ModellversucheFuentes (3) erklärt. Diese Befunde unterstreichen die Notwendigkeit, neben der Untersuchung der akzessorischen A-V-Leitung durch atriale Stimulation die retrograde akzessorische Leitung bei ventrikulärer Stimulation zu analysieren, da beim Ingangkommen supraventrikulärer Reentry-Tachykardien das funktionelle Verhalten der akzessorischen V-A-Leitung eine ausschlaggebende Rolle spielt.
    Notes: Summary In 15 patients with WPW-syndrome the atrio-ventricular and ventriculo-atrial conduction was studied by recording of intracardiac potentials during atrial and ventricular pacing. Typical differences in the patterns of normal and accessory A-V conduction identified accessory V-A conduction in 13 patients. According to the evaluation of accessory A-V and V-A conductivity by high rate pacing the patients studied can be divided into three groups: Group I (5 pat.): equally good accessory A-V and V-A conductivity. Group II (5 pat.): good accessory A-V and impaired accessory V-A conductivity. Group III (5 pat.): impaired accessory A-V and good V-A conductivity. In group I the course of investigation was repeated after the application of Ajmaline. The distinct heterodromia in group II and III and the different behaviour of the accessory A-V and V-A conduction after Ajmaline can be explained by the in vitro experiments ofFuente (3). According to our results and to the finding that an excellent accessory V-A conduction is a presupposition for the initiation of supraventricular re-entry tachycardia, it seems mandatory to analyze accessory A-V and V-A conduction properties as well.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01914333
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  • 9
    Electronic Resource
    Electronic Resource
    Doppelte Ventrikelerregung bei dualer AV-Knoten-Leitungsphysiologie: Katheterablation des langsamen Leitungsweges des dualen AV-Knotens (2000)
    Springer
    Zeitschrift für Kardiologie 89 (2000), S. 1014-1018 
    Details
    ISSN: 1435-1285
    Keywords: Key words Dual AV nodal conduction – double ventricular responses – slow pathway radiofrequency ablation ; Schlüsselwörter Duale AV-Knoten Leitungsphysiologie – doppelte Ventrikelerregung – Hochfrequenz-Katheterablation der langsamen Leitungsbahn
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Unterschiedliche elektrokardiographische Manifestationen einer dualen AV-Knoten-Leitungsphysiologie sind beschrieben. Ein besonders selten auftretender Subtyp stellt hier die doppelte ventrikuläre Erregung dar. Wir berichten über eine 53-jährige Patientin mit über sieben Jahren bestehenden typischen paroxysmalen regelmäßigen Tachykardien. In den vergangenen sechs Monaten kam es zu einer Änderung der vorbestehenden Symptomatologie der Herzrhythmusstörungen mit einem Wechsel zu länger anhaltenden und irregulär empfundenen Rhythmusstörungen. Medikamentöse Behandlungsversuche mit Antiarrhythmika der Klasse I waren nicht erfolgreich. Ein Therapieversuch mit Beta-Blockern verstärkte die subjektiven Beschwerden. Nach erneuter Befundung des EKG der Patientin wurde vom zuweisenden Krankenhaus die Diagnose einer dualen AV-nodalen Leitungsphysiologie mit doppelter Ventrikelerregung gestellt und die Patientin unserer Klinik zur invasiven elektrophysiologischen Untersuchung und zur Katheterablation des langsamen Leitungsweges des dualen AV-Knotens zugewiesen. Die invasive elektrophysiologische Untersuchung bestätigte die Diagnose eines dualen AV-Knotens mit doppelter Ventrikelerregung. Die Hochfrequenz-Katheterablation der langsamen Leitungsbahn erreichte die vollständige Unterbrechung der doppelten Ventrikelerregung. Das erfolgreiche Ablationsergebnis konnte durch Langzeit-EKG-Registrierung und Belastungsergometrie weiterführend bestätigt werden. Während einer dreimonatigen Nachbeobachtung blieb die Patientin vollständig asymptomatisch und es kam zu keiner Wiedererholung der dualen AV-Knoten Leitungsphysiologie im Oberflächen-EKG.
    Notes: Summary A variety of electrocardiographic manifestations of dual AV nodal physiology have been reported. The specific subtype dual ventricular response is considered as a very rare phenomenon. We present the case of a 53 year old lady who suffered from paroxysmal regular tachycardias for more than seven years. In the last 6 months the symptomatology of the cardiac arrhythmia changed to more persistent und irregular rhythm disturbances. Treatment with class Ia antiarrhythmic drugs and beta-blocking agents failed. The latter even seemed to worsen her very disturbing palpitations. After examination of the ECG recordings, the diagnosis of dual AV nodal physiology with double ventricular response was made – the lady was referred to our institution for electrophysiological testing and radiofrequency catheter ablation of the slow pathway. An invasive electrophysiological study reconfirmed the diagnosis of a dual AV nodal conduction pattern with irregular double ventricular response. The radiofrequency catheter ablation of the the slow pathway achieved a complete cessation of the double ventricular response. This satisfactory outcome was confirmed by analysis of a postinterventional 24hour holter recording and an exercise stress test. During a follow-up period of three months, the patient remained free of symptoms and there was no recurrence of dual AV nodal conduction physiology in the surface ECG.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003920070153
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