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  • 1
    Electronic Resource
    Electronic Resource
    Einflüsse von Bradykinin auf die systemische und die pulmonale Hämodynamik am Menschen (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 1085-1095 
    Details
    ISSN: 1432-1440
    Keywords: Bradykinin ; Blood pressure ; Prostaglandins ; Kallikrein-kinin system ; Pulmonary circulation ; Hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In our studies we investigated the vasodepressor effects of bradykinin in vivo in normotensive and hypertensive subjects. Bradykinin was injected intravenously and intraarterially (40–6050 pM/kg) respectively was infused intraarterially (40–6050 pM/kg/min). The investigations were performed in 21 normotensives and 15 hypertensives. Bradykinin injections were performed after the following pharmacological interventions: salt restriction (10 mmol Na/d), salt loading (300 mmol Na/d), captopril (50 mg), ramipril (5 mg), lisinopril (20 mg), ketotifen (2×1 mg), indomethacin (2×50 mg), and propranolol (80 mg). The results show that bradykinin lowers blood pressure dose related by marked reduction in peripheral vascular resistance. The blood pressure reduction was strongly correlated with the increase in kinin concentration. This effect of bradykinin appears to be independent of changes in sodium metabolism, of betaadrenoceptors, of histamin-1 receptors, and of prostaglandins. ACE-inhibitors potentiate the blood pressure lowering effect of bradykinin about 20- to 50-fold. In case of an intraarterial injection of bradykin in only 2–5% of the intravenously used dose of bradykinin are needed to produce an identical fall in blood pressure. From this experiments a pulmonary clearance rate of bradykinin over 95% can be calculated. In the pulmonary arteries bradykinin has no effect on the vascular resistance. In patients suffering from primary or renovascular hypertension the blood pressure response to bradykinin was enhanced. The bradykinin potentiating effect of the ACE-inhibitors was not altered in the hypertensives. In patients suffering from borderline hypertension or primary hyperaldosteronism bradykinin developed the same blood pressure lowering effect as in the normotensives.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01741783
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  • 2
    Electronic Resource
    Electronic Resource
    The mechanism of warfarin formation from 4-hydroxycoumarin and β-anilinobenzylacetone. Evidence for schiff base intermediates showing enhanced reactivity in the Michael reaction
    Amsterdam : Elsevier
    Tetrahedron Letters 1 (1960), S. 23-29 
    Details
    ISSN: 0040-4039
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4039(01)99315-3
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    CT and MRI of congenital sinonasal ossifying fibroma (1999)
    Springer
    Neuroradiology 41 (1999), S. 526-529 
    Details
    ISSN: 1432-1920
    Keywords: Key words Fibroma ; ossifying ; Dysplasia ; fibrous ; Nose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a 9-year-old boy with a sinonasal ossifying fibroma, probably congenital, with atypical findings on CT and MRI. CT revealed a soft-tissue density mass in the sphenoethmoidal sinuses, nasal cavity and right maxillary sinus with a few foci of calcification and with remodelling and destruction of the adjacent facial bones. MRI showed high signal on T2- and intermediate signal on T1-weighted images. A thin, partly enhancing outer shell and some nonenhancing septa were visible on contrast-enhanced images. MRI also showed the tumour to extend into the anterior cranial fossa. Subtotal removal was performed. We compare our findings with reports in the literature and discuss the differences from fibrous dysplasia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050798
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Focal grey matter heterotopias in monozygotic twins with developmental language disorder (1998)
    Springer
    European journal of pediatrics 157 (1998), S. 849-852 
    Details
    ISSN: 1432-1076
    Keywords: Key words Focal heterotopia ; Neuronal migration ; Developmental language disorder ; Monozygotic twins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe 9-year-old monozygotic male twins with a developmental language disorder of the phonologic-syntactic type and learning difficulties. High-resolution MRI revealed bilateral parieto-temporal grey matter heterotopias in both twins, on the left more than on the right, and more pronounced in the more affected twin. This suggests a causal relationship between the heterotopias and the neuropsychological findings in this twin pair. Conclusion Neuronal migration defects and ensuing focal heterotopias may be causally related to developmental language disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050951
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Goldenhar, Möbius and hypoglossia-hypodactyly anomalies in a patient: syndrome or association? (1996)
    Springer
    European journal of pediatrics 155 (1996), S. 385-389 
    Details
    ISSN: 1432-1076
    Keywords: Key words Goldenhar ; Möbius ; Hypoglossia-hypodactyly ; Vascular ; disruption sequences
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The Möbius, Goldenhar and hypoglossia-hypodactyly anomalies are usually sporadic conditions with a recurrence risk of about 2%. The combination of Goldenhar and one of the two others is rare, whereas the concomitant occurrence of Möbius and hypoglossia-hypodactyly, and/or Poland, and/or Klippel-Feil anomaly is well known. Pathogenetically, vascular disruptions around the 4th embryonic week have been hypothesized. In vivo and pathological studies as well as animal models support this theory for all the above-mentioned combinations. Whether a preceding blastogenetic alteration is an influencing factor or a disorganization mutation, remains unclear. We describe a 3-year-old girl with bilateral anotia, epidermoid on the right eye, 6th and 7th nerve palsy, hypoglossia, left hypodactyly, and ventricular septal defect. Conclusion We wish to emphasize the aetiological relevance of vascular disruptions in this previously unreported combination of Möbius, Goldenhar and hypoglossia-hypodactyly anomalies. The concurrence of anomalies in this patient represents an association and not a pleiotropic syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955267
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    Paper (German National Licenses)
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