Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1432-1440
    Keywords: Fulminante Lebernekrose ; Hirnödem ; Mannitol ; Kohlehämoperfusion ; Leberzellregeneration ; Fulminant liver necrosis ; Brain edema ; Mannitol ; Charcoal hemoperfusion ; Liver cell regeneration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The clinical course of a 26 year old female patient with acute liver necrosis and coma due to hepatitis B is reported. The disturbances of conciousness had improved. The patient survived 41 days after the beginning of the coma and developped livercell regeneration and an acute post-hepatitic liver cirrhosis. As a grave complication a septicemia with aspergillus was observed. The patient died because of gastro-intestinal hemorrhage. At autopsy there were no signs of brain edema. The treatment consisted in: daily infusions with coenzyme A, nicotinamid-adenin-dinucleotide, alpha lipoic acid and cocarboxylase to improve the metabolic disorders and the clinical picture; mannitol intravenously to prevent and to treat cerebral edema; 33 charcoal-hemoperfusions to remove toxic substances of acute liver failure. Treatment of the aspergillus infection with 5-fluorocytosine and amphotericine B and infusion of concentrated ascites led to a decompensation of liver functions. From this observation the following conclusions can be drawn: after an acute viral hepatic necrosis, new synthetic functions and improvements of the disturbed intermediary metabolism in regenerated liver-cells can eventually be seen only after twenty-four to thirty days. With systematically applicated mannitol infusions it is possible to treat cerebral edema effectively.
    Notes: Zusammenfassung Es wird der Verlauf einer durch Hepatitis B bedingten, akuten Lebernekrose mit Coma bei einer 26jährigen Patientin beschrieben. Die Bewußtseinsstörung besserte sich. Die Patientin überlebte 41 Tage und entwickelte Leberzellregenerate und eine akute posthepatitische Leberzirrhose. Im Verlauf trat als schwere Komplikation eine Pilzsepsis auf. Die Patientin starb an einer Magendarmblutung. Bei der Autopsie fand sich kein Hirnödem. Die Behandlung beständ in täglichen Infusionen von Coenzym A, Nikotinamid-adenin-dinukleotid, alpha-Liponsäure und Cocarboxylase zur Besserung von metabolischen Störungen und klinischem Bild; Mannitol intravenös, zur Verhinderung und Behandlung des Hirnödems; 33 Kohlehämoperfusionen, zur Entfernung toxischer Substanzen. Behandlung der Aspergillus-Infektion mit 5-Fluorocytosin und Amphotericin B und Infusion des konzentrierten Ascites führten zu einer Dekompensation der Leberfunktionen. Aus dieser Beobachtung können folgende Schlüsse gezogen werden: Nach einer akuten viralen Lebernekrose kann es erst nach 24–30 Tagen zur Wiederaufnahme synthetischer Funktionen und zur Besserung des gestörten Intermediärstoffwechsels in regenerierten Leberzellen kommen. Mit systematischer Mannitol-Therapie ist es möglich, das Hirnödem wirksam zu bekämpfen.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    facet.materialart.
    Unknown
    Paris : Periodicals Archive Online (PAO)
    Etudes anglaises. 43:1 (1990:janv./mars) 120 
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 11 (1975), S. 93-100 
    ISSN: 1432-0428
    Keywords: Diabetic coma ; ketoacidosis ; non-ketotic hyperosmolar coma ; acidosis ; mortality ; blood urea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The admission data and the course of 58 episodes of severe diabetic ketoacidotic coma and of 28 episodes of non-ketotic coma are compared. The non-ketotic patients were older; initial blood glucose, osmolarity, blood urea and serum sodium concentration were higher than in the ketotic patients. Treatment in the first 24 hrs consisted of similar amounts of insulin in both coma forms, the presence of acidaemia did not increase the insulin needs. Acidaemia was corrected only when pH was below 7.20. The disadvantages of alkali therapy are emphasized. A comparison of the age groups of survivors and those patients who died within 72 hrs showed an increase in mortality with age. However, the mortality rates from ketotic and non-ketotic coma were similar in the age groups above 50 years. On admission, blood glucose, osmolarity and blood urea were higher in the fatal cases. Blood urea was the most important indicator of a fatal outcome. The response of blood glucose to insulin was impaired in the subsequently fatal cases. Insulin was given in “moderate” doses by constant infusion. The use of “small” doses is discussed. Early mortality was 14% in the ketotic and 29% in the non-ketotic cases. The most frequent causes of death were circulatory failure of undetermined origin, infections and thromboembolic complications.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 18 (1992), S. 469-473 
    ISSN: 1432-1238
    Keywords: Erythromycin ; Ventricular arrhythmia ; Electrocardiographic intervals ; QTc ; Critically ill
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To evaluate the incidence of prolongation of the rate-corrected electrocar diographic QT interval (QTc) and of ventricular arrhythmia associated with intravenous administration of erythromycin lactobionate. Design A consecutive series of 7 critically ill patients treated with intravenous erythromycin for severe pneumonia. Setting A medical intensive care unit of a university hospital. Measurements and results Registration of QTc duration before and after intravenous administration of erythromycin as a short infusion. Blood chemistry, hemodynamic variables, arrhythmias, and co-medications were recorded., Evaluation of at least 10 ECG intervals by 2 experienced investigators who were blinded as to the time of drug administration If several measurements were performed in the same patient, only the mean value was used for further analysis. During 12 of 13 drug administrations studied in 7 patients QTc prolongation was observed. The extent of QTc prolongation was significantly correlated with the infusion rate (mg/min,r=0.765,p=0.05). In 3 patients ventricular arrhythmia occurred in close temporal relation to the erythromycin infusion; two of them developed ventricular fibrillation shortly after the first and second dose of erythromycin, respectively, and died within 3 h. Conclusion In critically ill patients erythromycin-induced QTc prolongation is a frequent pharmacologic effect correlated with erythromycin infusion rate. To avoid changes in electrocardiographic intervals and thereby possibly potentially life-threatening ventricular arrhythmia administration with the lowers possible infusion rate and close cardiac rhythm monitoring are advisable in these patients.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 17 (1991), S. 188-188 
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 22 (1996), S. 721-721 
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1432-1238
    Keywords: Key words Work of breathing ; Tracheostomy tube ; Ventilator weaning ; ATC ; Upper airway resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To determine the tracheostomy tube-related additional work of breathing (WOBadd) in critically ill patients and to show its reduction by different ventilatory modes. Design: Prospective, clinical study. Setting: Medical ICU of a university teaching hospital. Intervention: Standard tracheostomy due to prolonged respiratory failure. Measurements and results: Ten tracheostomized, spontaneously breathing patients were investigated. As the tube resistance depends on gas flow, patients were subdivided according to minute ventilation into a low ventilation group ( = 10 l/min; n = 5) and a high ventilation group ( 〉 10 l/min; n = 5). The WOBadd due to tube resistance and non-ideal ventilator properties was calculated on the basis of the tracheal pressure measured. Ventilatory modes investigated were: continuous positive airway pressure (CPAP), inspiratory pressure support (IPS) of 5, 10, and 15 cm H2O above PEEP, and automatic tube compensation (ATC). In the low ventilation group, WOBadd during CPAP was 0.382 ± 0.106 J/l. It was reduced to below 15 % of that value by ATC or IPS more than 5 cm H2O. In the high ventilation group WOBadd during CPAP increased to 0.908 ± 0.142 J/l. In this group, however, only ATC was able to reduce WOBadd below 15 % of the value observed in the CPAP mode. Conclusions: The results indicate that, depending on respiratory flow rate, (1) tracheostomy tubes can cause a considerable amount of WOBadd, and (2) ATC, in contrast to IPS, is a suitable mode to compensate for WOBadd at any ventilatory effort of the patient.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1432-1238
    Keywords: Carboxyhemoglobin ; Acute myocardial infarction ; Complications ; Ventricular arrhythmias
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To clarify the influence of an elevated carboxyhemoglobin (COHb) blood level on the course of acute myocardial infarction and to evaluate the administration of supplemental oxygen on the COHb level and the incidence of complications. Design Prospective clinical study with randomized, unblinded intervention. Setting Coronary Care Unit of a university hospital. Patients 78 consecutive patients with acute myocardial infarction. Excluded were patients with severe dyspnea, pulmonary edema or any other medical indication for supplemental oxygen therapy. Interventions Randomized therapy with 4l/min oxygen in 35 patients.Measurements and results: COHb was measured at admission and 4 h later. The incidence of serious arrhythmias and the maximal creatine kinase (CK) values were recorded. In patients with initial COHb≧5%, there were significantly more arrhythmias and significantly higher maximal CK values than in those with normal COHb at admission (89 vs 33%,p〈0.001; and 1897±1602 u/l vs 960±1097 u/l,p=0.05). This effect was seen only in patients with Q-wave infarction, not in those with non-Q-wave infarction. Supplemental oxygen had no effect on the incidence of arrhythmias. Conclusions We conclude that myocardial infarction patients with acute Q-wave infarction and increased COHb levels at admission suffer a more severe course of the disease. This outcome was not influenced by oxygen therapy. Whether this finding indicates a causal relationship and whether higher oxygen concentrations would favorably alter the course of acute myocardial infarction remain to be determined.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 22 (1996), S. 1385-1390 
    ISSN: 1432-1238
    Keywords: Key words Midazolam ; Sedation ; Weaning ; Heart rate variability ; Prediction model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To determine the relationship between the clinically evaluated depth of midazolam-induced sedation and the cardiac beat-to-beat variability (RR variability) in ICU patients in the intensive care unit (ICU). Design: Prospective study. Setting: ICU of a university hospital. Patients: 20 consecutive patients studied during weaning from mechanical ventilation and withdrawal of midazolam-induced sedation. Measurements and results: After clinical evaluation of depth of sedation according to the Ramsay sedation score, the RR variability over 512 RR intervals and predominant respiratory rate were measured. The power spectrum of RR variability was calculated by a fast Fourier transformation and the resulting total frequency band (0.016–0.35 Hz) was subdivided into a very low, a low, and a high frequency band. Stepwise multiple regression analysis in the first 10 patients (group 1) showed a significant relationship between depth of sedation and measures of RR variability combined with respiratory rate (r 2=0.59; F=12.1; p〈0.001).The more effective sedation was, the more depressed were both RR variability and predominant respiratory rate. Mean heart rate, mean respiratory rate, median deviation of RR intervals from the mean, and the ratio between spectral power density in the high and the low frequency bands proved to be the most important predictors of the Ramsay score (±1 level accuracy: 87%, p〈0.001). Using this regression equation, the Ramsay score was predicted in the remaining 10 patients (group 2) with a ±1 level of accuracy of 81% (p〈0.001). Conclusion: In ICU patients, a significant correlation is found between the depth of midazolam-induced sedation as assessed by the Ramsay sedation score and RR variability, with a clinically sufficient prediction accuracy. RR variability can serve as an objective, continuously available, and non-invasive measurement to monitor midazolam-induced sedation in intubated and mechanically ventilated patients.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 16 (1990), S. 242-247 
    ISSN: 1432-1238
    Keywords: Flumazenil ; Anexate ; Benzodiazepine antagonist ; Intoxication ; Overdose reversal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a double-blind placebo-controlled prospective clinical trial we studied the efficacy and safety of the benzodiazepine antagonist, flumazenil. In 23 patients admitted to the Intensive Care Unit with coma due to overdose with benzodiazepines or other sedatives, flumazenil i.v. (up to 2mg or placebo) was given. In 13 patients given flumazenil the Glasgow Coma Scale (GCS) increased significantly from 4.9 to 7.8 (p〈0.05). Six of these 13 patients, including mainly benzodiazepine mono-intoxications, needed only one series of injections (up to 1.0 mg flumazenil); the GCS increased thereby from 4.5 to 10.7 within a maximum of 5 min (p〈0.01). In the remaining 7 patients, needing two series of injections of flumazenil (up to 2.0 mg), GCS did not rise significantly and coma was related to intoxications with nonbenzodiazepine sedatives, flunitrazepam and in one patient, encephalitis. In the 10 patients receiving placebo, the GCS did not change. A significant increase in the GCS from 5.5 to 10.8 (p〈0.001) was, however, observed when flumazenil (up to 1.0 mg) was given after placebo. In patients with EEG monitoring the changes in waveform pattern paralleled the clinical response. Effects could be detected within 1–2min after flumazenil injection and lasted up to 45min. There were no adverse reactions or benzodiazepine withdrawal symptoms. We conclude that flumazenil is an effective and safe drug in the treatment of benzodiazepine overdose. The use of flumazenil is of diagnostic value in mixed-drug intoxications or coma of unknown origin and is of therapeutic importance for reversal of benzodiazepine intoxications.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...