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  • 1
    Electronic Resource
    Electronic Resource
    Evidence that cyclosporine inhibits periodontal prostaglandin I2 synthesis (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 31 (1996), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cyclosporine (CsA) is a selective immunosuppressant widely used in clinical therapy. Like phenytoin and nifedipine, the drug is associated with gingival overgrowth. This study considers the interaction of CsA and prostaglandin I2 (PGI2), in particular the action of the drug on gingival tissue in vitro and in vivo. The PGI2-synthesis of rat, rabbit and human gingival tissue was examined by bioassay. In vivo CsA-therapy reduces gingival PGI2-synthesis. The results furthermore show a dose-dependent inhibition of PGI2-synthesis by CsA (1–100 μg/ml) in vitro. PGI2-synthesis from in vivo CsA-pretreated probes was further dose-dependently diminished by in vitro addition of CsA. As PGI2 exerts an antiproliferative activity via cAMP-elevation, the drug-induced inhibition of PGI2 production is claimed to be responsible for gingival hyperplasia in CsA-treated patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1996.tb00474.x
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of sE-selectin and L-selectin on the regulation of cell migration during chronic periodontitis (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 30 (1995), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Soluble endothelial leukocyte adhesion molecule-1 (sE-selectin) levels in peripheral blood (PB) and gingival capillary blood (GCB) of both healthy donors (HD) and patients with adult periodontitis (AP) were assayed by ELISA. Binding of sE-selectin to polymorphonuclear neutrophils (PMN) from PB, GCB and crevicular fluid (GF), and expression of L-selectin and sialyl-Lewisx (sLex) on these cells were analyzed by immunofluorescence and flow cytometry. No significantly enhanced serum levels of sE-selectin in patients with AP. compared to HD (28±5 ng/ml vs 19±3 ng/ml, respectively), and no differences in the concentration of sE-selectin in GCB (16±1 ng/ml vs 16±2 ng/ml, respectively) were observed. On PB-PMN no significant differences in the expression of L-selectin and sLex were found and binding of sE-selectin to PB-PMN was comparable between HD and patients with AP. Binding of sE-selectin to GCB-PMN was significantly higher in patients with AP compared to HD (mean channel fluorescence (MCF)=88.5± 13.2 vs MCF=24.2±5.3, respectively). The expression of sLex on GCB-PMN did not differ significantly between the two groups. A significant decrease in the expression of the adhesion molecule L-selectin on GCB-PMNs compared to PB-PMN was found in patients with AP but not in HD. CF-PMN showed decreased expression of both L-selectin and sLex compared to PMN from PB and GCB, both in HD and patients with AP. Taken together, these data suggest that PMN from patients with AP had reduced selectin-mediated adhesive capabilities to inflamed gingival endothelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1995.tb01274.x
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  • 3
    Electronic Resource
    Electronic Resource
    Characteristics of the cancellous bone of edentulous mandibles (1997)
    Copenhagen : Munksgaard International Publishers
    Clinical oral implants research 8 (1997), S. 0 
    Details
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Trabecular bone volume and trabecular connectivity (trabecular bone pattern factor) of edentulous mandibles were examined using undecalcified bone sections from the region of the 1st premolar to investigate atrophyrelated changes in mandibular cancellous bone. The mean trabecular bone volume was 21.8% in female mandibles and 36.4% in male mandibles. The mean trabecular bone pattern factor was -0.22 mm−1 for female mandibles and -2.29 mm−1 for male mandibles. The difference between the sexes was statistically conspicuous for both parameters, but did not attain statistical significance. A notable fact was the extreme range of variation in both trabecular bone volume and trabecular connectedness. A difference of 65% between the highest and the lowest trabecular bone volumes measured in the present study (min, 7.6%; max, 73.6%, both male) reflects the possible variation in trabecular density of edentulous mandibles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0501.1997.080207.x
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  • 4
    Electronic Resource
    Electronic Resource
    Nitric oxide synthesis is increased in periodontal disease (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 33 (1998), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1998.tb02352.x
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  • 5
    Electronic Resource
    Electronic Resource
    Ursachen odontogener Kieferhöhlenentzündungen (1999)
    Springer
    HNO 47 (1999), S. 748-755 
    Details
    ISSN: 1433-0458
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001060050457
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  • 6
    Electronic Resource
    Electronic Resource
    Sex-related changes in the bone mineral content of atrophic mandibles (1994)
    Springer
    Calcified tissue international 54 (1994), S. 203-207 
    Details
    ISSN: 1432-0827
    Keywords: Mandible ; Atrophy ; Bone mineral content
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract In 25 edentulous anatomical mandible specimens (15 female, age range 69–90 years; 10 male, age range 68–88 years), the bone mineral content (BMC) was measured by dual-photon absorptiometry (DPA) and analyzed in a standardized area of the mandibular body. The results of our BMC examinations showed that there was a significant difference (P=0.05) between the two sexes. Another notable fact was that, with advancing age, the values measured in the male mandibles tended to increase slightly but in a statistically significant way. Those of the female mandibles tended to decrease with age. A possible explanation for this observation may be derived from the fact that a reduction of the mandibular height leads to a reduction of the moment of resistance. As functional adaptation in order to preserve the stability of the atrophic body of the mandible, the amount of inner cortical bone of the male mandibles increases, leading to a reduction of the cancellous portion. In the mandibles of women, postmenopausal osteoporosis seems to prevent an analogous compensation mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00301679
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  • 7
    Electronic Resource
    Electronic Resource
    Dental-CT zur Planung chirurgischer Eingriffe Bedeutung im oro-maxillofazialen Bereich aus zahnärztlicher Sicht (1999)
    Springer
    Der Radiologe 39 (1999), S. 1051-1063 
    Details
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Computertomographie ; Dental-CT ; Orale Chirurgie ; Operationsplanung ; Präimplantologische Diagnostik ; Schablonen ; Computerunterstützte chirurgische Navigation ; Key words Computed tomography ; Dental CT ; Oral surgery ; Preimplantological diagnostics ; Templates ; Computer assisted surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Dental computer assisted tomography (Dental CT) represents a valuable addition to the diagnostic spectrum for planning oral and maxillofacial surgery. High resolution CT and specially designed computer software allow representation of the jaws in different planes that are easy to match. They further allow the display of very small structures relevant to oral surgical interventions and reveal their spatial relationship in three dimensions. Thus communication between dentists and radiologists may be intensified and supported by usage of modern telecommunication systems. Dental CT is indicated, when clinical and conventional radiological techniques will not allow exact interpretation of the situation. It is modern oral implantology that primarily benefits from computer software enabling the assessment of surgical sites in the presurgical phase. Such planning was not yet possible using two dimensional radiographic techniques. The dental-implantological part expects from radiography sharply defined contours of the external bony contours and the mandibular canal, exactly defined relation between slices and planes, no distortion in the orthoradial planes, tools for reliable measurements of distances, angles and volumes, possibility to transmit pictures electronically or on hardcopy without loss of quality.
    Notes: Zusammenfassung Dentale Computertomographie (Dental-CT) stellt neben Orthopantomographie, intraoralem Zahnfilm und Fernröntgen eine wertvolle Erweiterung des diagnostischen Spektrums zur Planung chirurgischer Eingriffe im oro-maxillofazialen Bereich dar. Durch die Möglichkeiten von hochauflösendem CT und der Entwicklung von Software zur Darstellung des Kiefers in räumlich leicht zuordenbaren Schichtebenen, lassen sich auch kleinste, zahnärztlich-chirurgisch relevante Strukturen und ihre Lagebeziehung zueinander in allen drei Ebenen darstellen. Dadurch kann es zur intensiveren Kommunikation zwischen Zahnarzt und Radiologen kommen, was durch die Inanspruchnahme moderner Telekommunikationssysteme auch erleichtert wird. Dental-CT hat primär dort ihre Aufgabe, wo klinische und konventionell radiologische Verfahren keine exakte Beurteilbarkeit der Situation ermöglichen. Vor allem in der modernen Implantologie ergeben sich durch den Einsatz spezieller Computerprogramme Möglichkeiten der Operationsplanung, welche mit zweidimensionalen Röntgenverfahren nicht möglich sind. Die Anforderungen von zahnärztlich-implantologischer Seite an das Röntgen sind: klare Darstellung der äußeren Knochenkonturen und des Mandibularkanals, eindeutige räumliche Zuordnung der einzelnen Schnittbilder zueinander, Verzerrungsfreiheit in den orthoradialen Ebenen (Schnittebenen tatsächlich im rechten Winkel auf die äußeren Tangenten), Vermeßbarkeit und Ausgabemöglichkeit auf einem Bildträger ohne Qualitätsverlust.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001170050601
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  • 8
    Electronic Resource
    Electronic Resource
    Die Magnetresonanztomographie in der Dentalradiologie (Dental-MRT) (1999)
    Springer
    Der Radiologe 39 (1999), S. 1044-1050 
    Details
    ISSN: 1432-2102
    Keywords: Schlüsselwörter MRT ; Dental CT ; Dentalradiologie ; Pulpitis ; Dentogene Zysten ; Key words MRT ; Dental CT ; Dental radiology ; Pulpitis ; Dentigerous cysts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Purpose: To demonstrate the usefulness of Dental-MRT for imaging of anatomic and pathologic conditions of the mandible and maxilla. Methods: Seven healthy volunteers, 5 patients with pulpitis, 9 patients with dentigerous cysts, 5 patients after tooth transplantation and 12 patients with atrophic mandibles were evaluated. Studies of the jaws using axial T1- and T2-weighted gradient echo and spin echo sequences in 2D and 3D technique have been to performed. The acquired images were reconstructed with a standard dental software package on a workstation as panoramic and cross sectional views of the mandible or maxilla. Results: The entire maxilla and mandibula, teeth, dental pulp and the content of the mandibular canal were well depicted. Patients with innflammatory disease of the pulp chamber demonstrate bone marrow edema in the periapical region. Dentigerous cysts and their relation to the surrounding structures are clearly shown. After contrast media application marked enhancement of the dental pulp can be found. Conclusion: Dental-MRT provides a valuable tool for visualization and detection of dental diseases.
    Notes: Zusammenfassung Ziel dieses Beitrags ist die Vorstellung der Untersuchungsmöglichkeiten des Ober- und Unterkiefers mittels Magnetresonanztomographie (Dental-MRT) und ihre Anwendung bei der Diagnose zahnmedizinischer Erkrankungen. Sieben gesunde Probanden, 5 Patienten mit Pulpitis, 9 Patienten mit dentogenen Zysten, 5 Patienten nach Zahntransplantationen und 12 Patienten mit atrophem Unterkiefer wurden untersucht. Axiale T1- und T2-gewichtete Gradientenecho- und Spinecho-Sequenzen in 2D und 3D-Technik wurden durchgeführt. Nach der Untersuchung wurden zusätzliche Panoramaschnitte und orhoradiale Rekonstruktionen des Ober- und Unterkiefers, unter Verwendung einer gebräuchlichen Dental-Software, angefertigt. Der gesamte Ober- oder Unterkiefer, Zähne, Pulpa und der Inhalt des Mandibularkanals können gut dargestellt werden. Patienten mit einer Entzündung der Zahnwurzel können ein deutliches Knochenmarksödem in der Periapikalregion zeigen. Bei Patienten mit odontogenen Zysten ist die Beziehungen zu den umgebenden Kieferstrukturen gut darstellbar. Nach Kontrastmittelgabe zeigt sich ein Enhancement in der Zahnpulpa. Die Dental-MRT ist ein nützliches Verfahren zur anatomischen Darstellung des Kieferbereichs und zahnmedizinischer Erkrankungen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001170050600
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  • 9
    Electronic Resource
    Electronic Resource
    Precision of three-dimensional CT-assisted model production in the maxillofacial area (1992)
    Springer
    European radiology 2 (1992), S. 473-477 
    Details
    ISSN: 1432-1084
    Keywords: Three dimensional ; Computed tomography ; Individual skull model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Individual skull model fabrication was introduced into preoperative diagnostics in maxillofacial surgery in the mid-1980s. The aim of the present study was to collect information on the reproducibility of a skull model milled from hardened polyurethane foam. This model was based on the CT data of a real skull. Twenty comparative studies were carried out on both the model and the original skull, the model showing an average inaccuracy of 1.6 mm. The deviations ranged between 0.0 and 3.6 mm; the general trend favouring enlargements. The total deviation of the model as compared to the original skull was 1.8%. A convincing aspect of the model, which cannot be obtained by any other method, is its plasticity and the possibility of 3 D orientation on a lifesize model. This new method is already used in preoperative planning of corrections of post-traumatic defects and craniofacial deformities as well as in tumour surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00176356
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