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  • 1
    Electronic Resource
    Electronic Resource
    The influence of guanidino and isothiourea groups in histaminergic compounds on H2-activity (1986)
    Springer
    Inflammation research 18 (1986), S. 137-140 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Because in some alkylenediisothioureas replacement of one of the isothiourea groups by a guanidino group resulted in a strong increase in agonistic histamine H2-activity, while replacement of the guanidino group of a potent analogue of impromidine by an isothiourea group resulted in a complete loss of histamine H2-activity, it was concluded that guanidino and isothiourea groups are not bio-isosteric for the H2-receptor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01988004
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  • 2
    Electronic Resource
    Electronic Resource
    Histamine H2-binding on guinea pig cerebral cortex (1986)
    Springer
    Inflammation research 18 (1986), S. 231-234 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The Kd-values of some histamine H2-active compounds, obtained from radio-ligand-binding studies on a homogenate of the guinea-pig cerebral cortex with3H-tiotidine as the labelled H2-ligand, were compared with the pA2/pD2-value of these compounds on the guinea-pig right atrium and guinea-pig isolated gastric fundus. A good correlation was found between the pKd of the H2-antagonists and their pA2 on the guinea-pig right atrium. A much poorer correlation however was obtained between the pKd of the agonists on the cerebral cortex and their pD2-values on the guinea-pig right atrium and the gastric fundus. This poor correlation between true affinity and H2-activity of the agonists might be explained by spare receptors as a much better correlation was obtained between pKd and pD2 of partial agonists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01988028
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  • 3
    Electronic Resource
    Electronic Resource
    Abstracts of Dutch doctoral theses (1988)
    Springer
    Pharmacy world & science 10 (1988), S. 26-29 
    Details
    ISSN: 1573-739X
    Keywords: Blood pressure ; Enalapril ; Kidney function ; Kininase 11 ; Natriuresis ; Renin-angiotensin system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966432
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  • 4
    Electronic Resource
    Electronic Resource
    Synthesis and pharmacology of a series of new organic nitrate esters (1995)
    Springer
    Pharmacy world & science 17 (1995), S. 120-125 
    Details
    ISSN: 1573-739X
    Keywords: Alcohols ; Chemical synthesis ; Nitrates ; Pharmacology ; Structure-activity relationship ; Vasodilator agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract New organic nitrate esters, derived from structurally different (cyclo)aliphatic templates, were synthesized and pharmacologically investigated. Theirin vitro vascular smooth muscle relaxing activities and, occasionally,in vivo haemodynamic profiles were studied and compared to those of the clinically important nitrates, glyceryl trinitrate, isosorbide dinitrate and isosorbide-5-mononitrate. A number of compounds appeared to be even more potent than glyceryl trinitrate. Qualitative structure-activity relationships within the series of new compounds are discussed. In flexiblen-alkylene dinitrates, lipophilicity as well as chain length appears to affectin vitro activity. In semi-rigid cyclohexylene dinitrates, the number of atoms between and the configuration of the nitrate groups may play an important role. Finally, in cycloalkylene mononitrates neither the number of ring carbon atoms nor the lipophilicity clearly affects thein vitro activity. It is suggested that, apart from a limited involvement of compound lipophilicity, other factors such as differences in enzymatic conversion to a common putative bioactive species, nitric oxide, are responsible for the observed differences in activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01872388
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  • 5
    Electronic Resource
    Electronic Resource
    Results of the fifth joint pesticide testing programme carried out by the IOBC/WPRS-Working Group “Pesticides and beneficial organisms” (1991)
    Springer
    BioControl 36 (1991), S. 55-67 
    Details
    ISSN: 1573-8248
    Keywords: pesticides ; side effects ; beneficial arthropods ; parasites ; predators ; entomopathogenic fungi ; IOBC ; pesticides ; effets secondaires ; arthropodes utiles parasites ; prédateurs ; champignons entomopathogènes ; OILB
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Résumé Les essais de tous niveaux (depuis le laboratoire jusqu'au plein champ) pour établir les effets de 20 pesticides sur 19 organismes utiles différents, ont été menés par les membres du groupe de travail «Pesticides et Organismes utiles» de l'OILB/SROP. Ce 5e programme coordonné d'essais pesticides a été réalisé par 21 participants appartenant à 11 pays européens. Les pesticides (7 insecticides, 8 fongicides et 5 herbicides) qui furent choisis en fonction de leur sélectivité possible ont été essayés selon les principes internationaux approuvés. Parmi les 20 préparations essayées les acaricides Appolo SOSC, Cesa S.KL.; les fongicides Baycor, Delan, Vitigran, Impact, Rovral PM et les herbicides Luxan 2,4-D amine, Ally et Dirigol-N furent sans danger pour presque tous les organismes utiles essayés et furent recommandés pour les programmes de Lutte Intégrée. L'essai ultérieur des 10 préparations restantes est recommandé. Les activités du groupe de travail pour terminer le développement d'une procédure urgente pour contrôler les effets secondaires des pesticides sur les organismes utiles et la nécessité d'une coopération plus internationale sont discutées.
    Notes: Abstract Laboratory, semi field and field tests to assess the side effects of 20 pesticides on 19 different beneficial organisms were carried out by members of the Working Group “Pesticides and Beneficial Organisms” of the International Organization for Biological Control (IOBC), West Palearctic Regional Section (WPRS). This 5th joint pesticide testing programme of the working group was carried out by 21 participants in 11 European countries. The pesticides (7 insecticides, 8 fungicides and 5 herbicides), that were chosen for their possible selectivity, were tested according to internationally approved principles. Among the 20 preparations tested, the insecticides Apollo SOSC, Cesar S.L., the fungicides Baycor, Delan flüssig, Vitigran, Impact, Rovral PM, and the herbicides Luxan 2,4-D amine, Ally and Dirigol-N were harmless to nearly all the beneficial organisms tested and are recommended for use in integrated control programmes. The further testing of the remaining 10 preparations is recommended. The activities of the working group to complete the development of urgently needed sequential procedure to test the side effects of pesticides on beneficial organisms based on standard laboratory, semi field and field methods and the need for more international cooperation are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02374636
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  • 6
    Electronic Resource
    Electronic Resource
    Results of the seventh joint pesticide testing programme carried out by the IOBC/WPRS-Working Group ‘Pesticides and Beneficial Organisms’ (1999)
    Springer
    BioControl 44 (1999), S. 99-117 
    Details
    ISSN: 1573-8248
    Keywords: beneficial arthropods ; entomopathogenic fungi ; natural enemies ; parasitoids ; predators ; side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract The side effect of 10 insecticides, 5 fungicides and 5 herbicides on 24 different species of beneficial organisms was tested by members of the Working Group ‘Pesticides and Beneficial Organisms’ of the International Organization for Biological Control (IOBC), West Palaearctic Regional Section (WPRS). The tests were conducted by 32 members in 12 countries according to internationally approved guidelines. The microbial insecticides Bacillus thuringiensis var. kurstaki (Delfin), B. thuringiensis var. tenebrionis (Novodor) and Verticillium lecanii (Micro Germin), the fungicides cyproconazol (Alto), difenoconazol (Score), lecithin (Bioblatt Mehltau) and penconazol (Omnex), and the herbicides ethofumesat (Tramat), fluroxypyr (Starane), haloxyfop (Gallant), isoproturon (Arelon) and metamitron (Goltix) were harmless to nearly all the beneficial arthropods. The benzoylurea's teflubenzuron (Nomolt) and flufenoxuron (Cascade) affected predators such as anthocorids, earwigs, coccinellids and lacewings. The remaining preparations were more toxic and should therefore be further tested in semi-field and field experiments on relevant organisms. Most tested fungicides were toxic for the entomopathogenic fungi.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009959009802
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  • 7
    Electronic Resource
    Electronic Resource
    Results of the sixth joint pesticide testing programme of the IOBC/WPRS-working group «pesticides and beneficial organisms» (1994)
    Springer
    BioControl 39 (1994), S. 107-119 
    Details
    ISSN: 1573-8248
    Keywords: pesticides ; side effects ; beneficial arthropods ; natural enemies ; parasitoids ; predators ; entomopathogenic fungi ; IOBC ; International Organization for Biological Control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Résumé Les effets secondaires de 5 insecticides, 8 fongicides et 6 herbicides sur 24 espèces auxiliaires ont été étudiés par les membres du Groupe de travail «Pesticides et Organismes utiles» de l'OILB, Organisation Internationale de Lutte biologique Section Régionale Ouest Paléarctique (SROP). Les tests ont été effectués par 24 participants appartenant à 11 pays, et selon des directives internationalement approuvées. L'insecticide buprofézine (Applaud), les fongicides triforine (Saprol), promycidone (Sumisclex), anilazine (Dyrène), triademinol (Bayfidan), hexaconazole (Anvil), tridémorphe (Calixin) et les berbicides tralkoxydime (Grasp), bentazone (Basagran) se sont révélés sans danger pour presque tous les auxiliaires. Le diflubenzuron (Dimilin) avait un effet néfaste sur les araignées et les larves d'insectes prédateurs. Les 10 préparations restantes étaient plus toxiques et doivent donc faire l'objet d'autres essais sur les organismes utilisés.
    Notes: Abstract The side effects of 5 insecticides, 8 fungicides and 6 herbicides on 24 species of beneficial organisms were tested by members of the Working Group «Pesticides and Beneficial Organisms» of the International Organization for Biological Control (IOBC), West Palaearctic Regional Section (WPRS). The tests were conducted by 24 members in 11 countries according to internationally approved guidelines. The insecticide buprofezin (Applaud), the fungicides triforine (Saprol), procymidone (Sumisclex), anilazine (Dyrene), triadimenol (Bayfidan), hexaconazole (Anvil), tridemorph (Calixin) and the herbicides tralkoxydim (Grasp), bentazone (Basagran) were harmless to nearly all the beneficial organisms. Diflubenzuron (Dimilin) affected spiders and the larvae of predatory insects. The remaining 10 preparations were more toxic and should therefore be further tested in semi-field and field experiment on relevant organisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02373500
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