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  • 1
    Electronic Resource
    Electronic Resource
    Respiratory syncytial virus infection: its role in aeroallergen sensitization during the first two years of life (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Pediatric allergy and immunology 7 (1996), S. 0 
    Details
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Our aim was to study the influence of infection with the respiratory syncytial virus (RSV) in non-hospitalized infants on sensitization to aeroallergens and the early manifestation of atopy. Six hundert and nine infants from the prospective German Multicenter Cohort Study on Atopy were included, 38% of whom had an elevated atopic risk. RSV IgG and IgM antibodies were tested by ELISA with gradient purified RSV antigen. Specific IgE against mites, cat dandruff, birch and grass pollens and relevant nutritional antigens were tested with CAP-RAST-FEIA (Pharmacia, Sweden). Of the cord sera 99% were positive for RSV-IgG, 44. 7% at one year and 64. 2% (n=265) at two years of age. The positivity rate after 12 months varied with the season of birth, the number of siblings and the degree of exposure to tobacco smoke; and correlated closely with attacks of wheezing during infancy. Twenty (2. 8%) children were found to be sensitized against at least one aeroallergen at one year, and 28 (10. 5%) at two years. By the first birthday, mite sensitization (n=3) could only be seen in the RSV-infected children; grass pollen sensitization (n=9) was associated with RSV seropositivity (logistic regression model including the confounders mentioned above: with RSV IgG p=0.04 〉 and IgM p=0.0006), as was birch sensitization (n=5) with RSV IgM (p=0.009). No such differences could be detected at two years. No correlation of RSV seropositivity to any allergic manifestation could be found. We conclude, that it is only in the first year of life, that RSV infection plays a significant role in promoting sensitization against aeroallergens, which do not at this time produce allergic symptoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1399-3038.1996.tb00107.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Die radioimmunologische Messung von Ferritin im Serum und ihre klinische Bedeutung (1977)
    Springer
    Journal of molecular medicine 55 (1977), S. 1103-1107 
    Details
    ISSN: 1432-1440
    Keywords: Serum ferritin ; Immunoradiometric assay ; Body iron stores ; Serumferritin ; Immunoradiometrischer Assay ; Körpereisenstatus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ferritin ist ein Eisenspeicher-Protein, dessen Vorkommen im Serum erst vor wenigen Jahren nachgewiesen wurde. Es wird über die immunoradiometrische Messung von Ferritin im Serum bei insgesamt 324 Personen mit unterschiedlichem Körpereisenstatus berichtet. Der Mittelwert bei gesunden Normalpersonen beträgt für Frauen 67 µg/l (SD: 1,79) und für Männer 131 µg/l (SD: 1,59). Für männliche und weibliche Dauerblutspender sowie Patienten mit Eisenmangel bzw. Eisenüberladung wurden davon signifikant unterschiedliche Ferritinkonzentrationen im Serum gefunden. Die Bestimmung des Ferritins im Serum kann damit als wertvoller und leicht verfügbarer Parameter zur Beurteilung der Eisenspeicher angeschen werden.
    Notes: Summary Ferritin is an iron storage protein which has been shown to be present in blood serum only recently. An immunoradiometric determination of ferritin in 324 subjects with different iron stores is reported. In healthy men and women a ferritin concentration of 131 µg/l (SD: 1,59) and 67 µg/l (SD: 1,79) was found respectively. In male and female blood donors as well as patients with iron deficiency and iron overload significant differences of serum ferritin concentration could be demonstrated. In clinical practice the determination of serum ferritin is a valuable method for the estimation of body iron stores.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477937
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Inhibition of sound-induced convulsions by metoprine in the audiogenic seizure susceptible rat (1987)
    Springer
    Inflammation research 20 (1987), S. 252-254 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Metoprine which increases brain histamine by blocking its methylation, was recently demonstrated to inhibit electrically induced tonic convulsions in rats. Its effect was now tested on audiogenic convulsions in genetically audiogenic seizure sensitive rats. Metoprine (20 mg/kg, i.p.) reduced the severity of seizures significantly 4 and 28 h after drug administration. Also the duration of convulsions was significantly decreased. These results agree with an involvement of histaminergic neurons in convulsive phenomena perhaps as a part of an anticonvulsive inhibitory transmitter system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02074683
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    Paper (German National Licenses)
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