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  • 1
    Electronic Resource
    Electronic Resource
    Purification and properties of nucleoside triphosphate-adenosine monophosphate transphosphorylase from beef heart mitochondria (1970)
    s.l. : American Chemical Society
    Biochemistry 9 (1970), S. 2462-2470 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00814a011
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Absorption rates of subcutaneously injected insulin in the dog as calculated from the plasma insulin levels by means of a simple mathematical model (1983)
    Springer
    Diabetologia 24 (1983), S. 196-201 
    Details
    ISSN: 1432-0428
    Keywords: Dog ; insulin therapy ; mathematical model ; soluble insulin ; depot insulin ; absorption ; subcutaneous
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The appearance rate of insulin (calculated insulin secretion rate) in the circulating blood after subcutaneous injection was estimated in diabetic dogs from serial measurements of immunoreactive insulin concentrations using a simple mathematical model based on the insulin half-life and the distribution space. In the case of highly purified monocomponent porcine insulin, maximum concentrations occurred after 30–60 min. The duration of insulin appearance was dose-dependent and the rate of appearance could be described by a bi-exponential function. It was linearly dose-dependent but the effect on glycaemia showed saturation kinetics. The action of the injected dose on the fasting glycaemia diminished when the appearance rate became 〈0.3 mU · kg-1 · min-1. Fractional dose recovery was between 70% and 90% and was not different between depot and regular insulin. Appearance kinetics were not significantly affected by the initial glycaemia. The model presented provides a means for quantitative characterization of different insulin preparations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00250161
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Alterations in alanine metabolism in diabetic dogs during short-term treatment with an artificial B cell (1985)
    Springer
    Diabetologia 28 (1985), S. 763-768 
    Details
    ISSN: 1432-0428
    Keywords: Artificial B cell ; dog ; experimental diabetes ; alanine metabolism ; gluconeogenesis ; tracer study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The flux rates of plasma glucose and alanine were studied isotopically (6-3H-glucose and U-14C-alanine simultaneously) in resting chronically diabetic dogs during short-term treatment with an artificial B cell where the insulin was infused into a peripheral vein. Despite perfect blood glucose control and normal glucose flux rates, the concentration and rates of appearance and disappearance of alanine were significantly elevated in the diabetic animals before, during and after an exogenous glucose load. The incorporation of the carbon moiety of alanine into circulating glucose was also increased, but diminished to a near-normal extent when exogenous glucose was given. The plasma clearance rates for alanine in the diabetic dogs were normal throughout the study. It is concluded that normal blood glucose control in diabetes does not necessarily mean normalization of the entire metabolic network. On the basis of peripheral hyperinsulinaemia alanine formation from glucose and branched chain amino acids is elevated in muscle. This may explain increased flux of alanine despite normal blood glucose control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265025
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Assessment of an algorithm for the artificial B-cell using the normal insulin-glucose relationship in diabetic dogs and men (1980)
    Springer
    Diabetologia 18 (1980), S. 97-107 
    Details
    ISSN: 1432-0428
    Keywords: Artificial B-cell ; algorithm ; glucose-insulin relationship ; regression analysis ; insulin secretion ; insulin half-life ; human diabetes mellitus ; experimental diabetes mellitus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Insulin secretion rates after glucose loading were calculated from peripheral venous IRI concentrations considering half life and distribution space of exogenous insulin in normal men and dogs. The coefficients of multiple linear regression analysis between insulin secretion rates and plasma glucose (level and order and rate of change) were used as algorithm parameters in glucose-controlled insulin infusions. These were carried out in each dog based on individual estimations before the induction of diabetes but in the diabetic patients based on values derived from a group of normal subjects. Using this formula, nearly normal patterns of glucose and of insulin were observed in diabetic men and dogs under basal conditions and after IV glucose loading but not after meals. This algorithm enables selection of the parameters prospectively. The effect of a parameter combination depends on insulin sensitivity and it should be appropriately adapted. In the diabetic patients there was no predictable influence of the brittle or stable characteristics of the disease nor of insulin antibodies on the glucose curves obtained with glucose controlled insulin infusions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00290484
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Clinical comparison of methylprednisolone aceponate and prednicarbate in chronic eczema (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the European Academy of Dermatology and Venereology 3 (1994), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Methylprednisolone aceponate (MPA) is a new topical corticosteroid developed specifically for the treatment of eczematous disorders. A multicentre, controlled, randomized open trial to assess the efficacy and tolerability of a once daily application of MPA in comparison to a twice-daily application of Prednicarbate (PC) was conducted in 566 patients suffering from allergic contact eczema (51.2%), toxic degenerative eczema (46.8%) as well as a combination of allergic contact eczema and toxic degenerative eczema (1,9%). Both treatment groups were approximately the same size, 280 patients being treated with MPA, 286 with PC.Treatment was carried out for a maximum of 28 days. The median duration of treatment was 22 days with MPA and 21 days with PC. Clinical efficacy was not different between MPA ointment (0.1%) used once daily with 45.5% complete healing and 39.8% marked improvement as compared to PC ointment (0.25%) used twice daily with 48.3% complete healing and 40.2% marked improvement. Both treatments were well tolerated. 4.6% of the patients reported adverse events on MPA-treatment and 3.8% on PC-treatment. No serious events were experienced. From this study it can be concluded that in various eczematous disorders efficacy and tolerability of MPA ointment used once daily are essentially the same as for PC ointment used twice daily.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.1994.tb01063.x
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  • 6
    Electronic Resource
    Electronic Resource
    Thiophenol-N-base hydrogen bonds. Proton polarizability and proton transfer within these bonds
    Amsterdam : Elsevier
    Chemical Physics Letters 105 (1984), S. 598-603 
    Details
    ISSN: 0009-2614
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-2614(84)85664-X
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Heating of A z-pinch plasma by CO"2-laser radiation
    Amsterdam : Elsevier
    Physics Letters A 65 (1978), S. 119-120 
    Details
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9601(78)90590-X
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Flow conditioning for improved optical propagation of beams through regions bounded by surfaces of high solidity (1991)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 69 (1991), S. 1915-1922 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A flow conditioning system has been designed to maximize the thermal homogeneity in an enclosed region through which a laser beam must propagate. In the present application, such an enclosed region exists between the Nd:glass disks of a high average power solid-state laser amplifier. Experiments have been conducted on a test facility to quantify the magnitude of the beam losses due to thermal scattering. It is shown that the intensity of the incoherent light which is thermally scattered from this region can be reduced to less than 0.1% of the incident-beam intensity under apropriate flow and cooling conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.348762
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Optimum performance considerations for a large-aperture average power solid-state laser amplifier (1991)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 69 (1991), S. 1183-1191 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The effect of a gas cooling system on the efficiency of an average-power solid-state disk laser amplifier is addressed. Such a configuration has application in solid-state fusion drivers. Analytical models are discussed that identify the important parameters in specifying an optimized laser and optimized cooling system. It is shown that the penalty that the cooling and conditioning system power requirements have on the overall laser system efficiency can be easily maintained below 10%, particularly for large-aperture systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.347302
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    100 W average power at 0.53 μm by external frequency conversion of an electro-optically Q-switched diode-pumped power oscillator (1994)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 64 (1994), S. 3086-3088 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have generated approximately 100 W of frequency doubled light from the output of an electro-optically Q-switched diode-pumped Nd:YAG slab laser oscillator operating at an average power of 200 W (2.5 kHz repetition rate, 80 mJ/pulse, 30 ns pulsewidth). The Q-switch was a compensated z-axis propagation LiNbO3 electro-optic modulator, and the frequency conversion crystal was a thin slab of KTP. In addition, Q-switched operation at an average power of approximately 250 W with 26 ns pulsewidths has been demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.111355
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    Paper (German National Licenses)
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