ISSN:
1432-0428
Keywords:
Dog
;
insulin therapy
;
mathematical model
;
soluble insulin
;
depot insulin
;
absorption
;
subcutaneous
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The appearance rate of insulin (calculated insulin secretion rate) in the circulating blood after subcutaneous injection was estimated in diabetic dogs from serial measurements of immunoreactive insulin concentrations using a simple mathematical model based on the insulin half-life and the distribution space. In the case of highly purified monocomponent porcine insulin, maximum concentrations occurred after 30–60 min. The duration of insulin appearance was dose-dependent and the rate of appearance could be described by a bi-exponential function. It was linearly dose-dependent but the effect on glycaemia showed saturation kinetics. The action of the injected dose on the fasting glycaemia diminished when the appearance rate became 〈0.3 mU · kg-1 · min-1. Fractional dose recovery was between 70% and 90% and was not different between depot and regular insulin. Appearance kinetics were not significantly affected by the initial glycaemia. The model presented provides a means for quantitative characterization of different insulin preparations.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00250161
