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  • 1
    Electronic Resource
    Electronic Resource
    Adsorption preferences of ammonia on vanadium pentoxide catalysts: a theoretical analysis of a critical step in ammoxidation processes (1990)
    s.l. : American Chemical Society
    Langmuir 6 (1990), S. 365-370 
    Details
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/la00092a013
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  • 2
    Electronic Resource
    Electronic Resource
    Eighth annual meeting of the European Association for the Study of Diabetes (1973)
    Springer
    Diabetologia 9 (1973), S. 57-96 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01226005
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Kinetics and mechanisms in the ammoxidation of toluene over a titania (B)-supported vanadium oxide monolayer catalyst. 2. Combustion reactions (1991)
    s.l. : American Chemical Society
    Industrial & engineering chemistry research 30 (1991), S. 320-326 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie00050a007
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  • 4
    Electronic Resource
    Electronic Resource
    Kinetics and mechanisms in the ammoxidation of toluene over a titania (B)-supported vanadium oxide monolayer catalyst. 1. Selective reactions (1991)
    s.l. : American Chemical Society
    Industrial & engineering chemistry research 30 (1991), S. 312-320 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie00050a006
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  • 5
    Electronic Resource
    Electronic Resource
    Oxidation catalysis on YBa 2 Cu 3 O 6+x (1988)
    [s.l.] : Nature Publishing Group
    Nature 334 (1988), S. 143-145 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We synthesized YBa2Cu3O7 from stoiehiof & etric aniwtnti of Y2O3, BaCO3 and CuO as described in the legend to Fig, 1. YBa2Cu3O6 was similarly prepared and used as a reference, Prepared substances were characterized by X-ray powder diffraction (see Table 1), high resolution electron microscopy ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/334143a0
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  • 6
    Electronic Resource
    Electronic Resource
    Acute effects of different immunosuppressive drugs on pancreatic, islet, renal, and arterial hepatic blood flow in anesthetized rats (1994)
    Springer
    Transplant international 7 (1994), S. 319-323 
    Details
    ISSN: 1432-2277
    Keywords: Cyclosporin A, pancreatic blood flow, rat ; RS 61443, pancreatic blood flow, rat ; Deoxyspergualin, pancreatic blood flow, rat ; FK 506, pancreatic blood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of four different immunosuppressive drugs on organ blood flow were investigated. Sprague-Dawley rats were injected intravenously with 0.2 ml of either 15-deoxyspergualin (DSG; 5 mg/kg body weight), RS 61443 (80 mg/kg body weight), FK 506 (0.5 mg/kg body weight), cyclosporin A (9.5 mg/kg body weight), or the vehicles used. At 15 or 60 min after injection of the drugs, the blood perfusion of the whole pancreas, the pancreatic islets, and the kidneys, as well as the arterial blood flow to the liver, were measured in anesthetized animals using a microsphere technique. Fifteen minutes after administration, both FK506 and DSG decreased the fraction of whole pancreatic blood flow diverted through the islets. FK 506 and cyclosporin A reduced renal blood flow, but only 60 min after injection of the drug. None of the drugs influenced hepatic blood flow. RS 61443 did not affect the blood flow of the organ systems investigated. These differences in the effects of the drugs tested on blood flow might have some important implications on their efficacy and side effects. Thus, in view of its lack of influence on organ blood flow, RS 61443 seems to be preferable, at least when compared with cyclosporin A and FK 506 in the context of organ transplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336705
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of cyclosporin A on the blood flow of the native and transplanted rat pancreas and duodenum (1993)
    Springer
    Transplant international 6 (1993), S. 143-147 
    Details
    ISSN: 1432-2277
    Keywords: Pancreas transplantation, rat ; Pancreas transplantation, blood flow ; Cyclosporin, pancreas transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the present study was to evaluate the effects of cyclosporin A (CyA) on the blood perfusion of the transplanted pancreas. For this purpose syngeneic pancreaticoduodenal transplantations were performed in Wistar-Furth rats. After nephrectomy the graft was anastomosed using a nonsuturing cuff technique to the left renal vessels. Beginning 7 days after transplantation and then continuing for 2 weeks, CyA (15 mg/kg body weight) or vehicle was given p.o. once daily, 6 days a week. The serum CyA concentrations were greater than 600 ng/ml at all points in time tested. Intraperitoneal glucose tolerance tests were normal in CyA-treated animals after 12 days, but the pancreatic insulin concentration was decreased to the same extent in the native and transplanted pancreas. A microsphere technique was used to measure the blood perfusion of the pancreaticoduodenal graft, the native pancreas and duodenum, and remaining kidney 14 days after starting the CyA treatment. The renal blood flow was markedly decreased by CyA when compared with the control animals. In rats given vehicle alone, pancreatic, islet, and duodenal blood flows were higher in the graft than in the corresponding native organs. However, in rats given CyA, hyperperfusion of the graft was not observed. We conclude that the administration of CyA prevents the transplantation-induced blood flow increase seen in pancreaticoduodenal grafts of vehicle-treated rats. These observations may reflect graft denervation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336357
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  • 8
    Electronic Resource
    Electronic Resource
    Ultrastructure of monolayer cultures of pancreatic islet cells (1970)
    Springer
    Acta diabetologica 7 (1970), S. 557-589 
    Details
    ISSN: 1432-5233
    Keywords: Islets of Langerhans ; Isolated islet cells ; Monolayer culture ; Ultrastructure of islet cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Cellules insulaires isolées obtenues de souris obèse-hyperglycémiques et de cobayes normaux ont été cultivéesin vitro pour des périodes de temps allant jusqu'à 7 jours. L'étude ultrastructurelle a montré que les cellules cultivées gardent les caractéristiques morphologiques des cellules insulairesin vivo. Des cellules α2 et β ont été identifiées chez des explants obtenus de souris obèse-hyperglycémiques et de cobayes normaux. Le caractère le plus remarquable des cellules insulaires cultivées est représenté par l'importante dégranulation des cellules β dans les deux espèces animales. L'intensité de la dégranulation n'était pas en rapport avec la concentration de glucose dans le milieu d'incubation.
    Abstract: Resumen Se han cultivadoin vitro durante períodos variables hasta un máximo de siete días, células insulares aisladas procedentes de ratones obesos hiperglicémicos y de cavias normales. El estudio ultraestructural ha demostrado que las células cultivadas mantienen las características morfológicas de las células insularesin vivo. En extracciones procedents de ratones obesos hiperglicémicos y de cavias normales, ha sido posible identificar células α2 y células β. La característica má saliente de las células insulares cultivadas está constituida por la acentuada degranulación de las células β en las dos especies de animales. El grado de degranulación no está en relación con la concentración de glucosa en el medio de incubación.
    Notes: Riassunto Cellule insulari isolate ottenute da topi obesi-iperglicemici e da cavie normali sono state coltivatein vitro per periodi di tempo fino a 7 giorni. Lo studio ultrastrutturale ha dimostrato che le cellule coltivate mantengono le caratteristiche morfologiche delle cellule insulariin vivo. In espianti provenienti da topi obesi-iperglicemici e da cavie normali, è stato possibile identificare cellule α2 e cellule β. La caratteristica più saliente delle cellule insulari coltivate è costituita dalla marcata degranulazione delle cellule β in entrambe le specie animali. Il grado di degranulazione non era in rapporto con la concentrazione di glucosio nel mezzo di incubazione.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01556806
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  • 9
    Electronic Resource
    Electronic Resource
    Long-term effects of glibenclamide on the insulin production, oxidative metabolism and quantitative ultrastructure of mouse pancreatic islets maintained in tissue culture at different glucose concentrations (1981)
    Springer
    Acta diabetologica 18 (1981), S. 65-83 
    Details
    ISSN: 1432-5233
    Keywords: Electron microscopy ; Glibenclamide ; Glucose oxidation ; Insulin biosynthesis ; Insulin secretion ; Islets of Langerhans ; Mitochondria ; Morphometry ; Tissue culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to evaluate long-term effects of sulphonylureas on pancreatic islet structure and function, isolated mouse islets were maintained in tissue culture for one week at various glucose concentrations, and in the absence or presence of glibenclamide. When the islets were cultured at 3.3 or 5.5 mmol/1, but not at 16.7 mmol/1 glucose, it was found that the drug stimulated insulin secretion into the culture medium during the initial 3 days of culture. During the remainder of the culture period no such enhancement of secretion was demonstrated. Insulin release due to glibenclamide apparently resulted in rapid depletion of intracellular insulin stores. The finding of an enlarged B-cell Golgi apparatus in the drug-treated islets was probably associated with granule discharge. The failure of glibenclamide to promote insulin secretion during the whole culture period could reflect the adverse effects of the drug on islet insulin biosynthesis as indicated by short-term experiments performed after culture. Similar experiments showed that the impaired insulin biosynthesis could not be restored by withdrawal of the drug from the culture medium for 3 days. Furthermore, the capacity for insulin release in response to an acute glucose challenge at the end of the culture period, was abolished by culture in the presence of glibenclamide. The drug effects on insulin biosynthesis and intracellular insulin stores, which were most pronounced at 5.5 mmol/1 glucose, possibly resulted from changes in B-cell metabolism as suggested by the diminished islet glucose-oxidation rate. The spatial characteristics of islet mitochondria indicated that these changes might involve an adaptation to substrates other than glucose. In conclusion, our findings suggest that sulphonylureas have an insulinotropic effect, which is however transient. Indeed, it rather seems as if long-term exposure of islet B-cells to sulphonylureasin vitro were accompanied by functional deficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02056108
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  • 10
    Electronic Resource
    Electronic Resource
    Ammoxidation of toluene over Y-Ba-Cu-Co-O perovskites (1990)
    Springer
    Catalysis letters 6 (1990), S. 33-42 
    Details
    ISSN: 1572-879X
    Keywords: Ammoxidation ; toluene ; benzonitrile ; YBa2Cu3O6+x ; YBa2Cu2CoO6+x ; YBaCuCoO5 ; perovskites ; oxide catalysts ; superconductors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Ammoxidation of toluene over the perovskites YBa2Cu3O6.1, YBa2Cu2CoO6.7 and YBaCuCoO4.9 was investigated at 400 °C. At low partial pressures of O2 benzonitrile was selectively formed, while CO2 was the main product at high pressures of O2. Systematic differences in activity were observed for the three phases and are related to the crystal contents of Cu and Co. At low O2 pressures, Cu-sites are active for nitrile formation, while Co-sites give CO2. At high O2 pressures, the activity for CO2 of Cu-sites increases more than that of Co-sites due to filling of near-surface oxygen vacancies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00764050
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