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  • 1
    Electronic Resource
    Electronic Resource
    Macrovascular disease in caucasoid diabetic patients (1985)
    Springer
    Diabetologia 28 (1985), S. 385-386 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00283149
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Improved glucose tolerance four hours after taking guar with glucose (1980)
    Springer
    Diabetologia 19 (1980), S. 21-24 
    Details
    ISSN: 1432-0428
    Keywords: Dietary fibre ; guar ; glucose tolerance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To gain some insights about the possible cumulative metabolic effect after a high-fibre meal, 6 subjects took two 80 g oral glucose loads, 4 h apart. Addition of 22.3 g guar to the first load decreased the rise in blood glucose and insulin after the second (guar-free) load by 50% (p〈0.002) and 31% (p〈 0.02) respectively. This corresponded with decreased 3-hydroxybutyrate levels at the start of the glucose tolerance test after guar (by 20%, p〈0.02). When no guar was added to the first glucose load, both 3-hydroxybutyrate and non-esterified fatty acids tended to rise before the second test. No significant effect was seen in the responses of the gut hormones, gastric inhibitory peptide and enteroglucagon. Spreading the intake of the first 80 g of glucose over the initial 4 h (2 subjects) similarly flattened the glycaemic but increased the insulin response. The effect of guar on carbohydrate and fat metabolism, therefore, lasts at least 4 h and may result in improved carbohydrate tolerance to subsequent guar-free meals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00258305
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Chlorpropamide-alcohol flushing and plasma chlorpropamide concentrations in diabetic patients on maintenance chlorpropamide therapy (1983)
    Springer
    Diabetologia 24 (1983), S. 210-212 
    Details
    ISSN: 1432-0428
    Keywords: Chlorpropamide-alcohol flushing ; chlorpropamide ; alcohol ; flushing ; body temperature ; diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Forty-three diabetic patients on maintenance chlorpropamide (100–750 mg daily) drank 0.2 ml/kg 90% ethanol after equilibration in a room controlled at 20° C. Twenty-five patients had already noted marked alcohol flushing since starting chlopropamide therapy (group A), while 13 had not observed this (group B). The remainder were teetotal or unsure of their reaction. Cheek temperature rise correlated with plasma chlorpropamide concentration (r=0.6, p〈0.001) in all patients and was inversely related to basal cheek temperature (r=-0.35, p〈0.02). Plasma chlorpropamide correlated with daily chlorpropamide dose (r=0.8, p〈0.001) but not with basal cheek temperature. The correlation between chlorpropamide level and cheek temperature rise was strengthened on analysis of group A alone (r=0.7, p〈0.001) and absent in group B (r=0.2, p〉0.3) who tended to have lower chlorpropamide levels and cheek temperature rise than group A.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00250164
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  • 4
    Electronic Resource
    Electronic Resource
    UK prospective study of therapies of maturity-onset diabetes (1983)
    Springer
    Diabetologia 24 (1983), S. 404-411 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes ; therapy ; diet ; insulin therapy ; sulphonyl-urea ; biguanide ; epidemiology ; body weight ; fasting plasma glucose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A multi-centre, prospective randomised study of the therapy of maturity-onset diabetes has been started, and we report progress of the first 286 patients with 1-year followup. Newly presenting patients (aged 25–65 years inclusive) were initially treated by diet and divided into three categories. (1) Forty-one patients (14%) were ‘primary diet failure’ in that they continued to have symptoms or their fasting plasma glucose remained 〉15 mmol/l. Their therapy was allocated randomly to insulin, chlorpropamide or glibenclamide, and doses adjusted to try to maintain a fasting plasma glucose 〈6 mmol/l. Insulin produced a similar decrease in fasting plasma glucose to sulphonylurea therapy (median fasting plasma glucose fell from 15.4 to 8.0 mmol/l and from 15.5 to 8.6 mmol/l, respectively). (2) After 3–4 months diet, 161 patients (56%) were asymptomatic but had a fasting plasma glucose 〉6 mmol/l. In the ‘main randomisation’ their therapy was allocated to diet only, or diet plus chlorpropamide, glibenclamide or a basal insulin supplement from ultralente insulin. On diet alone, fasting plasma glucose remained constant over 1-year follow-up (from 7.7 to 7.6 mmol/l), whereas it was reduced significantly by insulin (from 8.0 to 6.4 mmol/l), chlorpropamide (8.6 to 6.1 mmol/l) and glibenclamide (7.8 to 6.5 mmol/l). On diet alone, weight remained unchanged over 1 year but increased significantly on insulin, chlorpropamide or glibenclamide (median change ideal body weight +3.5%, +4% and +4%, respectively). Obese patients (〉20% over ideal weight) did not differ from normal weight diabetic subjects in either fasting plasma glucose or weight changes. Insulin therapy was associated with few hypoglycaemic episodes, with 8% of patients on ultralente insulin alone reporting an episode compared with 7% on chlorpropamide. Fifty-one patients (86%) randomised to insulin remain on it lyear later. (3) After 3–4 months on diet, 84 patients (30%) after dieting had a fasting plasma glucose 〈6 mmol/l. During the following year on diet alone 34 patients were less well controlled with a fasting plasma glucose 〉6 mmol/l and were included in a ‘delayed randomisation’. Thus 83% of all patients entered into the study had their therapy randomised by 1 year. Insulin and sulphonylurea therapy are equally effective in reducing glycaemia, and the study is being extended to determine if either therapy will prevent the complications of diabetes or have untoward long-term side effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257337
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  • 5
    Electronic Resource
    Electronic Resource
    Retinopathy is associated with higher glycaemia in maturity-onset type diabetes (1984)
    Springer
    Diabetologia 27 (1984), S. 198-202 
    Details
    ISSN: 1432-0428
    Keywords: Background retinopathy ; maturity-onset type diabetes ; glycosylated haemoglobin ; prospective study ; colour photography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a group of 149 maturity-onset type diabetic patients followed from diagnosis, 55 (37%) had retinopathy on colour photography 7 years later. Those patients with retinopathy had significantly greater glycaemia, as shown by higher fasting plasma glucose levels at diagnosis, larger mean values for fasting glucose 1, 3 and 5 years later, and higher random glucose and haemoglobin A1c at ophthalmic review (p = 0.001, 0.002, 0.007 and 0.001, respectively). Substantial retinopathy, as measured by 〉 5 microaneurysms, also correlated significantly with each index of glycaemic control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273806
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  • 6
    Electronic Resource
    Electronic Resource
    “Conventional” and high carbohydrate/high fibre/low fat diets in adults with established Type 1 (insulin-dependent) diabetes (1985)
    Springer
    Diabetologia 28 (1985), S. 793-793 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265030
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Lipid abnormalities in untreated maturity-onset diabetics and the effect of treatment (1979)
    Springer
    Diabetologia 16 (1979), S. 101-106 
    Details
    ISSN: 1432-0428
    Keywords: Untreated maturity-onset diabetes ; plasma cholesterol ; serum triglyceride ; lipoproteins ; ponderal index ; blood glucose ; diet ; sulphonylureas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plasma cholesterol and serum triglyceride levels and frequency of lipoprotein abnormalities were investigated in 126 untreated maturity-onset diabetics and 126 age- and sexmatched control subjects. Serum triglyceride levels were higher (mean: 1.67 mmol/l) and type IV hyperlipoproteinaemia occurred more frequently (16.7%) in the diabetic group as compared with the controls (1.29 mmol/l and 4.8% respectively). These findings were not explained by an excessive frequency of renal disease, hypertension or drug treatment amongst the diabetics. Normal men showed higher serum triglyceride (mean: 1.36mmol/l) and lower plasma cholesterol (mean: 5.6mmol/l) levels than normal women (1.21 mmol/1 and 6.4mmol/l respectively). No sex difference was seen amongst the diabetics. Triglyceride levels fell after one month of dietary treatment but only remained lowered in diabetics who required sulphonylureas for glycaemic control. After treatment for one year the correlation between serum triglycerides and blood glucose rose from r = 0.15 (NS) before treatment to r=0.43 (p〈0.001). Similarly the correlation between serum triglycerides and ponderal index rose from r=0.19 (NS) to r=0.28 (p〈0.02).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01225458
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  • 8
    Electronic Resource
    Electronic Resource
    Glycogen-laden hepatomegaly in diabetes (1965)
    Springer
    Diabetologia 1 (1965), S. 116-120 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs rapportent l'observation d'un homme âgé de 43 ans traité par l'insuline depuis 18 ans. Pendant les 3 dernières années il souffrait d'attaques nocturnes d'hypoglycémie. On constata une augmentation du foie dont une biopsie démontra une architecture normale, mais des dépôts considérablement élevés de glycogène. Après abolition des hypoglycémies par changement d'insuline, le volume et le contenu de glycogène du foie redevinrent normaux. Des rapports antérieurs d'hépatomégalie par dépôt glycogénique sont passés en revue; le mécanisme de cette hépatomégalie et particulièrement sa reversibilité, si l'hypoglycémie est évitée, est discuté.
    Abstract: Zusammenfassung Bericht über einen 43-jährigen Mann, der wegen seines Diabetes 18 Jahre lang mit Insulin behandelt wurde. In den letzten 3 Jahren hatte er nächtliche hypoglykämische Anfälle. Die Untersuchung ergab eine vergrößerte Leber, deren bioptische Untersuchung eine normale Struktur, aber einen deutlich erhöhten Glykogengehalt erkennen ließ. Nachdem das Insulin gewechselt wurde, sodaß Hypoglykämien nicht mehr auftraten, bildete sich die Lebervergrößerung zurück. Sie enthielt jetzt normale Mengen von Glykogen. Über frühere Angaben der „glycogen-laden hepatomegaly” wird berichtet, ihr Entstehungsmechanismus diskutiert, wobei besonders die Reversibilität des Zustandes berücksichtigt wird, wenn Hypoglykämien vermieden werden.
    Notes: Summary A 43-year old man is described who had been treated with insulin for diabetes for 18 years. For the last 3 years he had had nightly hypoglycaemic attacks. He was then found to have an enlarged liver, biopsy of which showed normal architecture but a markedly increased glycogen content. After his insulin was changed so that he no longer developed hypoglycaemia, his liver returned to normal size and normal glycogen content. Previous reports of glycogen-laden hepatomegaly are reviewed, and its mechanism is discussed, with special reference to its reversibility when hypoglycaemia is avoided.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421485
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  • 9
    Electronic Resource
    Electronic Resource
    Book reviews (1982)
    Springer
    Diabetologia 23 (1982), S. 545-545 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254311
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Non-uniform distribution of islet amyloid in the pancreas of ‘maturity-onset’ diabetic patients (1984)
    Springer
    Diabetologia 27 (1984), S. 527-528 
    Details
    ISSN: 1432-0428
    Keywords: Quantitative morphometry ; amyloid ; diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Quantitative morphometry of the pancreases of five ‘maturity-onset’ diabetic subjects has demonstrated more amyloid in islets of the head, body and tail (where it was found in a mean 29% of the islets occupying a mean 11% islet area) than in islets of the ‘pancreatic-polypeptide-rich’ lobule of the head (where amyloid was found in a mean of 3% of the islets occupying a mean of 0.7% islet area, both p〈 0.005). The nonuniform amyloid distribution may relate to the hormone content of the islet; the head and tail contained significantly more A, B and D-cells than the pancreatic-polypeptide-rich lobule in both non-diabetic subjects (n = 8) and diabetic patients (n = 5; p〈0.005). This result is compatible with the previous suggestion that amyloid may be derived from insulin or its precursors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00290389
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    Paper (German National Licenses)
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