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  • 1
    ISSN: 1432-0428
    Keywords: Dietary fibre ; guar ; glucose tolerance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To gain some insights about the possible cumulative metabolic effect after a high-fibre meal, 6 subjects took two 80 g oral glucose loads, 4 h apart. Addition of 22.3 g guar to the first load decreased the rise in blood glucose and insulin after the second (guar-free) load by 50% (p〈0.002) and 31% (p〈 0.02) respectively. This corresponded with decreased 3-hydroxybutyrate levels at the start of the glucose tolerance test after guar (by 20%, p〈0.02). When no guar was added to the first glucose load, both 3-hydroxybutyrate and non-esterified fatty acids tended to rise before the second test. No significant effect was seen in the responses of the gut hormones, gastric inhibitory peptide and enteroglucagon. Spreading the intake of the first 80 g of glucose over the initial 4 h (2 subjects) similarly flattened the glycaemic but increased the insulin response. The effect of guar on carbohydrate and fat metabolism, therefore, lasts at least 4 h and may result in improved carbohydrate tolerance to subsequent guar-free meals.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 23 (1982), S. 477-484 
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion The last decade has seen much interest in the physiological response to carbohydrate foods. Interest in dietary fibre emphasised the possible influence of events within the gastrointestinal tract on carbohydrate metabolism. Links have been established between digestibility and the glycaemic response to foods. However, the influence of food factors on these processes is ill understood. Nevertheless food form, certain types of fibre, other anti-nutrients and the nature of the starch-protein interaction may be major determinants. Genetic differences in the responses of different individuals to the same food remain to be explored. For example, the protein, gliadin, may act as a lectin [97] in susceptible individuals to the extent of causing villous atrophy (coeliac disease) and so severely limiting absorption. Coeliac disease and Type 1 diabetes are linked both in occurrence [98] and in the frequency with which sufferers share the same tissue antigens (HLA-B8 and DW3) [99–102]. Less dramatic alterations in absorptive capacity may be seen in subclinical coeliac disease or with other anti-nutrients. These, therefore, represent other ways in which food can modify the glycaemic response. Perhaps in those with impaired carbohydrate metabolism a mildly reduced absorptive capacity could be beneficial. In view of the present state of knowledge, the decisions of the American and Canadian Diabetes Associations and the British Diabetic Association to increase carbohydrate intake [1–3] may be seen as a worthwhile move to encourage not so much gastronomic licence, but, some would say, more frugal living. The frugality might be lightened by inclusion of new foods and preservation of certain ethnic dishes. Indeed choice for the diabetic may ultimately be greatly enhanced as indicated by two recently published diet guides [103, 104]. The advice was not intended to be thrust on all with a sweep of the pen but it will give support to those willing to prescribe, and those willing to accept, such diets. In addition, it has provided a tremendous impetus to further activity for those working in this field. For those unable to take the diets, continued exploration along these lines may result in new pharmaceutical approaches to the management of diabetes.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0428
    Keywords: Digestion in vitro ; post-prandial glycaemia ; rate of absorption ; dietary fibre ; dietary carbohydrate ; diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The amount of carbohydrate released at 1 and 5 h by digestion in vitro of 2 g carbohydrate portions of 14 foods by human digestive juices was compared with the area under the 2-h blood glucose response curve when 50 g carbohydrate portions were fed to groups of five to ten healthy volunteers. A significant relationship was found between the amounts of sugars and oligosaccharides liberated at 1 and 5 h and the food blood glucose area expressed as a percentage of the blood glucose area for 50 g glucose (r=0.8627 and 0.8618, p〈0.001). A significant relationship was also found between the glycaemic index and the food fibre content (p〈0.02) and between the glycaemic index and the glucose trapping capacity of the foods (p〈0.05). Legumes as a group liberated 56% less sugars and oligosaccharides (p〈0.01) than the eight cereal foods over 5 h. It is suggested that such studies in vitro may help to identify food of use for diabetic patients, and at the same time throw further light on factors which affect post-prandial glycaemia.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0428
    Keywords: Glycaemic index ; leguminous seeds ; low blood glucose rise ; diabetes ; diabetic diet ; fat ; sugars ; protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recently diabetic patients have been encouraged to increase their carbohydrate intake, but exact details of which foods to use are lacking. To determine whether sufficiently large differences existed to justify more specific dietary advice, we compared the glycaemic responses to 50 g carbohydrate portions of different foods, taken as breakfast test meals by groups of five to seven diabetic patients. Two-to threefold differences were seen amongst the 15 foods tested. The glycaemic responses for spaghetti, ‘All-bran’, rice and beans were significantly below those for bread, while ‘Cornflakes’ were above. Factors predicted to influence this were without effect, including: substituting wholemeal for white bread, increasing substantially the simple sugars (using ‘All-bran’ or bananas instead of wholemeal bread) and doubling meal protein by adding cottage cheese to bread. Paired comparisons of the glycaemic response to the five legumes with those of the seven other starchy foods (breads, spaghetti, rice, Cornflakes, oatmeal porridge and potatoes) showed that the mean peak rise in blood glucose concentration and mean area under the glucose curve after beans were 23 and 28% lower, respectively, than the mean for the other foods (p 〈 0.001). Such results suggest a potentially valuable role for dried leguminous seeds in carbohydrate exchanges for individuals with impaired carbohydrate tolerance. These large differences in the blood glucose response to different food cannot at present be predicted directly from tables of chemical composition. Nevertheless, physiological testing may both aid in understanding the factors responsible and help selection of the appropriate carbohydrate foods for the diabetic diet.
    Type of Medium: Electronic Resource
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