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  • 1
    Electronic Resource
    Electronic Resource
    Photoablation by UV and visible laser radiation of native and doped biological tissue (1989)
    Springer
    Applied physics 49 (1989), S. 463-467 
    Details
    ISSN: 1432-0649
    Keywords: 87.55.Hb ; 82.50.Fv ; 87.15.Mi ; 87.50.Eg
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Photoablation studies of biological material (human cornea) with UV and visible laser light show that effective, apparently non-conventional thermal photoablation can be achieved by introducing energy absorbing dopants in the tissue. Previously unknown high ablation rates of 80 Gmm/pulse have been observed. The results allow one to clearly postulate different ablation mechanisms for increasing laser fluence. The results are compared with the photoablation rates observed with 193 nm UV laser light on undoped human cornea. Explosive desorption has been found the dominant process involved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00325350
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    SOMATIC GENE THERAPY IN THE CARDIOVASCULAR SYSTEM (2001)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 63 (2001), S. 427-450 
    Details
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract This review surveys a range of approaches using plasmid DNA encoding the 165-amino-acid isoform of vascular endothelial growth factor (phVEGF165) to therapeutically modulate micro- or macrovascular endothelial cells, focusing on strategies to augment postnatal collateral circulation in arterial insufficiency or to accelerate re-endothelialization after balloon angioplasty to prevent restenosis. We focus on intra-arterial and intramuscular/intramyocardial gene transfer of the VEGF165 gene, the options that have been most thoroughly studied to date in patients. We review developmental and postnatal significance of the endothelial-cell-specific mitogen VEGF that has stimulated these studies and present limitations of current knowledge as well as challenges for the future.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.physiol.63.1.427
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    MANAGEMENT OF PERIPHERAL VASCULAR DISEASE (2005)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Medicine 56 (2005), S. 249-272 
    Details
    ISSN: 0066-4219
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Notes: The management of patients with peripheral arterial occlusive disease (PAD) has to be planned in the context of natural history, epidemiology, and apparent risk factors that predict deterioration. The ankle-brachial index to date has proved to be the most effective, accurate, and practical method of PAD detection. Given that PAD is a powerful indicator of systemic atherosclerosis and (independent of symptoms) is associated with an increased risk of myocardial infarction and stroke, as well as a six times greater likelihood of death, the prevalence and demographic distribution of measurable PAD becomes particularly relevant. Reliable information on interventions to confer symptom relief is much weaker and reflects discrepancies between published reports from centers of excellence and the experience of patients routinely treated in communities around the world. The impact of newer treatment modalities, such as complex endovascular procedures and therapeutic angiogenesis, has been a subject of recent controversy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.med.56.082103.104649
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Detection of allergen-specific IgE in tears of grass pollen-allergic patients with allergic rhinoconjunctivitis (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 26 (1996), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Allergic conjunctivitis is a common symptom amongst Type I (IgE-mediated) allergic diseases; and mosl frequently seen as rhinoconjunctivitis. However, the site of production and the significance of allergen specific IgE needs further elucidation.Objective We investigated whether the presence of IgE in tears of grass pollen allergic patients correlated with disease and clinical symptoms, whether the IgE binding pattern to the different grass pollen antigens was diflferent in sera and tears, and whether IgA antibodies to grass pollen allergens were present in tears. Finally, we looked whether specific IgE was produced locally or was exudated from serum. Methods Sera from 44 grass pollen allergic patients suffering from either allergic rhinitis (n=11) or allergic rhinoconjunctivitis (n= 33) and from healthy controls (n= l) were used for the experiments. Binding of specific IgE and IgA antibodies to the differyent groups of grass pollen allergens (Phleum pratense) was evaluated by means of immunobtotting.Results Specific IgE was detected in sera as well as in tears of allergic patients, whereby tear-derived allergen-specific IgE exerted similar specificities to the corresponding IgE from serum. The correlation between symptoms of ocular allergy and the presence of allergen-specific IgE in tears was highly significant (P 0.0001). In contrast, only a poor correlation was found between specific and/or total IgE in sera and the manifestation of ocular allergy (P = 0.73).Conclusion Allergen-specific IgE antibodies in tears seem to be produced locally rather than exsudated from serum. IgE in tears seems to be responsible for allergic conjunctivitis. IgA in tears cannot exert a protective function since the IgA antibodies recognize different antigens in a grass pollen (Phleum pratense) extract than IgE antibodies. The highly significant correlation between allergic conjunctivitis and the presence of specific tear IgE emphasizes the diagnostic value of immunoblots with tear IgE, especially in cases in which serum provides inconclusive results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1996.tb00059.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Comparing the behaviour of aluminium species within the hydrological cycle in Westland, New Zealand, and the Fichtelgebirge, Germany
    Amsterdam : Elsevier
    Catena 19 (1992), S. 241-258 
    Details
    ISSN: 0341-8162
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geography , Geosciences
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0341-8162(92)90027-9
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Blepharitis — a diagnostic and therapeutic challenge (1991)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 229 (1991), S. 224-227 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Over the last few years the number of patients with chronic bilateral blepharitis has increased dramatically. From January 1985 until the end of 1989, a total of 407 patients with this diagnosis underwent ophthalmological and dermatological investigations at our out-patient clinic. Keratoconjunctivitis sicca (KCS) in conjunction with blepharitis occurred in 14.5% of the patient population who also suffered from acne rosacea. A comparison of the spectrum of microorganisms that have previously been isolated from affected sites with data obtained in the present study revealed that the range of microorganisms associated with this chronic localized inflammation has apparently shifted in recent years. The prevalence of Staphylococcus aureus, which was considerable in the pre-antibiotic era, has markedly decreased, although a distinct entity of staphylococcal blepharitis seems to remain, either alone or in combination with seborrheic blepharitis (62.8% of our patients). The clinical picture, microbiological findings and therapy for this condition are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167872
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    Paper (German National Licenses)
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