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  • 1
    Electronic Resource
    Electronic Resource
    In vitro effects of pemphigus antibodies on skin (1978)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 99 (1978), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Acantholysis occurring in rhesus monkey skin explants cultured on sera of 9 pemphigus patients was found to be largely dependent on the titre of intercellular antibody, and not on the participation of complement. Skin explants cultured on normal human sera and pemphigoid sera failed to give rise to intercellular staining or to develop lesions.Six of eight ‘negative’ pemphigus sera with intercellular antibody titres of less than 20 on skin (and titres ranging from 20 to 160 on monkey oesophagus) reacted with the skin explants as revealed by direct immunofluorescence with an anti-IgG conjugate. The binding of antibodies from 3 of these 6 reactive sera resulted in some pathological changes in the explants. At least two of these 3 ‘negative’ sera came from pemphigus patients with skin lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1978.tb01958.x
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  • 2
    Electronic Resource
    Electronic Resource
    Relevance of complement fixing antinuclear antibodies (1999)
    Oxford, UK : Blackwell Science Ltd
    International journal of dermatology 38 (1999), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Connective tissue diseases (CTDs) are a heterogeneous group of disorders defined by the association of a variety of clinical manifestations with immunologic and other laboratory findings. Overlap of syndromes and aberrant findings appear rather frequently. Methods Sera of eight antinuclear antibody (ANA) negative, cases of subacute cutaneous lupus erythematosus (SCLE) with antibodies to Ro (SS-A) and a ninth case with clinical and laboratory signs of Sjögren’s syndrome and systemic lupus erythematosus (SLE) were tested for complement (C′) fixing antinuclear antibodies (C-ANAs). The ninth case was examined in depth by direct immunofluorescence (DIF) and a two-step “C + DIF” test of biopsies for C′ fixation to in vivo bound ANAs, as well as serum tests for C-ANA, ANA, and SCLE markers. Results Sera of five of the eight ANA negative, Ro(SS-A) positive SCLE cases had C-ANAs. The ninth case, a 50-year-old woman with clinical and laboratory signs of Sjögren’s syndrome and SLE, gave a strong positive C + DIF reaction in the skin biopsy for in vivo bound ANAs that fix C′, but negative ANAs and C-ANAs in routine serum tests; they revealed antimitochondrial antibodies. Serum tests on normal skin, however, revealed weak ANA and strong C-ANA reactions with in vitro fixed C′. Conclusions ANA negative cases of SCLE or Sjögren’s syndrome may have C-ANAs. A case with Sjögren’s syndrome and signs of SLE had both in vivo and in vitro C′ fixing ANAs. C-ANA tests can aid in the identification of such cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-4362.1999.00580.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Immunopathology of psoriasis (1979)
    Springer
    Archives of dermatological research 264 (1979), S. 65-71 
    Details
    ISSN: 1432-069X
    Keywords: Stratum corneum antibodies ; Immunofluorescence studies ; Polymorphonuclear leukocytes ; Proteases ; Stratum corneum-Antikörper ; Immunofluoreszenz-Untersuchungen ; Polymorphonukleare Leukozyten ; Proteinase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Untersuchungen der psoriatischen Hautveränderungen mittels der direkten und indirekten Immunofluorescenzmethode zeigen in der Hornschicht Immunoglobulin- und Komplementablagerungen auf. Das IF-Muster ist dasselbe wie bei der Bindung der im normalen Serum auftretenden anti-Stratum corneum-Antikörper an dem spezifischen Substrat, d.h. normaler Hornschicht. Die Bildung von Immunkomplexen zusammengesetzt von anti-Stratum corneum-Antikörpern scheint das Phänomen der «Squirting papilla» zu verursachen, wobei das normalerweise nicht zugängliche Stratum corneum unter der Einwirkung von Traumen oder Leukocyten-Proteinasen antigenisch wird. Die Proteinase-Produktion durch angeregte polymorphonukleare Leukocyten ist vermutlich ein wichtiger pathogenetischer Faktor in Psoriasis, wobei das Stratum corneum das Target ihrer Einwirkung ist und reaktiv (antigenisch) wird, was die in vivo-Fixation der Stratum corneum-Antikörper ermöglicht.
    Notes: Summary Immunofluorescence (IF) studies by the direct and indirect methods demonstrate immunoglobulins and complement bound in vivo in psoriatic scales. The IF pattern is comparable to that of stratum corneum antibodies (SCAb) bound in vitro on specific substrate, as visualized by the indirect IF method. Formation of immune complexes can be responsible for the “squirting papilla” phenomenon, and conversion of the stratum corneum — which is normally an inaccessible antigen — into its reactive form seems to be brought about by proteases of polymorphonuclear leukocytes. Stimulation of protease production by polymorphonuclears appears to be an important factor in the pathogenesis of psoriasis. The stratum corneum of the epidermis is probably the target, and becomes an antigen for SCAb present in the circulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417280
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    Paper (German National Licenses)
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