Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    High prevalence of risk factors for cardiovascular disease in parents of IDDM patients with albuminuria (1997)
    Springer
    Diabetologia 40 (1997), S. 1191-1196 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Insulin-dependent diabetes mellitus ; proteinuria ; insulin resistance ; hyperlipidaemia ; cardiovascular disease.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Life expectancy is shorter in the subset of insulin-dependent diabetic (IDDM) patients who are susceptible to kidney disease. Familial factors may be important. In this study the prevalence of cardiovascular disease mortality and morbidity and of risk factors for cardiovascular disease was compared in the parents of 31 IDDM patients with elevated albumin excretion rate (AER 〉 45 μg/min; group A) with that of parents of 31 insulin-dependent diabetic patients with normoalbuminuria (AER 〈 20 μg/min; group B). The two diabetic patient groups were matched for age and duration of disease. Information on deceased parents was obtained from death certificates and clinical records and morbidity for cardiovascular disease was ascertained using the World Health Organization questionnaire and Minnesota coded ECG. Hyperlipidaemia was defined as serum cholesterol higher than 6 mmol/l and/or plasma triglycerides higher than 2.3 mmol/l and/or lipid lowering therapy; arterial hypertension as systolic blood pressure higher than 140 mmHg and/or diastolic blood pressure higher than 90 mmHg and/or antihypertensive treatment. The percentage of dead parents was similar in the two groups (26 vs 20 % for parents of group A vs group B, respectively), but the parents of the diabetic patients with elevated AER had died at a younger age (58 ± 10 vs 70 ± 14 years; p 〈 0.05). Parents of diabetic patients with nephropathy had a more than three times greater frequency of combined mortality and morbidity for cardiovascular disease than that of the parents of diabetic patients without nephropathy (26 vs 8 %; odds ratio 3.96, 95 % CI 1.3 to 12.2; p 〈 0.02). Living parents of group A had a higher prevalence of arterial hypertension (42 vs 14 % p 〈 0.01) and hyperlipidaemia (49 vs 26 % p 〈 0.05) as well as higher levels of lipoprotein (a) [median (range) 27.2 (1–107) vs 15.6 (0.2–98) mg/dl; p 〈 0.05]. They also had reduced insulin sensitivity [insulin tolerance test: median (range) Kitt index: 3.7 (0.7–6.2) vs 4.8 (0.7–6.7)% per min; p 〈 0.05]. In the families of IDDM patients with elevated AER there was a higher frequency of risk factors for cardiovascular disease as well as a predisposition to cardiovascular disease events. This may help explain, in part, the high prevalence of cardiovascular disease mortality and morbidity in those IDDM patients who develop nephropathy. [Diabetologia (1997) 40: 1191–1196]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050806
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Role of insulin-like growth factor (IGF)-1 in the modulation of renal haemodynamics in Type I diabetic patients (2000)
    Springer
    Diabetologia 43 (2000), S. 922-926 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Glomerular filtration rate, renal plasma flow, growth hormone.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. We investigated in normotensive Type I (insulin-dependent) diabetic patients with normoalbuminuria the role of growth hormone-induced IGF-1 in the modulation of renal haemodynamics.¶Methods. We measured glomerular filtration (GFR) and renal plasma flow (RPF) at baseline and at 24 h after injection of different doses of growth hormone (0.1, 0.2, 0.4 U · kg–1· body weight–1) in six patients with normal GFR under a euglycaemic clamp. We also examined a 24-h profile of plasma growth hormone and IGF-1 during usual insulin therapy in two other groups each with seven patients with a lower (from 93 to 114 ml · min–1· (1.73 m2)–1) and higher (from 121 to 146 ml · min–1· (1.73 m2)–1) GFR.¶Results. Plasma growth hormone concentrations peaked 2 h after its injection and plasma concentrations of IGF-1 peaked about 24 h after the growth hormone injection. There was a significant increase in GFR and RPF 24 h after the highest dose of the growth hormone injection (corresponding to the highest IGF-1 concentration), from baseline values of 115 ± 24 and 536 ± 141 ml · min–1· (1.73 m2)–1 to 160 ± 33 and 657 ± 137 ml · min–1· (1.73 m2)–1, respectively (p 〈 0.01 for GFR and p 〈 0.05 for RPF). No differences were observed in the 24-h profile of growth hormone and IGF-1 plasma concentrations between the two groups; growth hormone and IGF-1 concentrations were lower than those obtained after the injection of 0.4 U · kg–1· body weight–1 of growth hormone.¶Conclusion/interpretation. These results show that pharmacological growth hormone-induced IGF-1 concentrations are required to modify renal haemodynamics in Type I diabetic patients and suggest that, under the “physiological” conditions of diabetes, IGF-1 has no role as a mediator of glomerular hyperfiltration. [Diabetologia (2000) 43: 922–926]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051470
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Localization of nitric oxide synthase immunoreactivity in mast cells of human nasal mucosa (1994)
    Springer
    Histochemistry and cell biology 102 (1994), S. 89-92 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Nitric oxide (NO)-synthase immunoreactivity has been detected for the first time in mast cells of human normal nasal mucosa, with an antibody specific for neuronal NO-synthase. Intense immunoreactivity was revealed in secretion granules of mast cells but was found in mast cell granules free in the extracellular matrix only in some instances; no reactivity was found in the cytoplasm of this or other cell types. These findings suggest that human nasal mast cells contain a particulate isoform of NO-synthase, which shares epitopes with neuronal NO-synthase and is rapidly removed from granules upon exocytosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00269011
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    The traveling salesman problem and its analogy with two-dimensional spin glasses (1989)
    Springer
    Journal of statistical physics 56 (1989), S. 547-551 
    Details
    ISSN: 1572-9613
    Keywords: Optimization problem ; two-dimensional spin glasses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The low-temperature regime of the Euclidean traveling salesman problem is studied numerically. The specific heat behavior is analyzed in terms of the number of cities and compared with that of spin-glasses. A properly defined order parameter shows the existence of freezing effects at low temperature. The Euclidean TSP behaves as a spin glass in two dimensions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01044452
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...