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  • 1
    Electronic Resource
    Electronic Resource
    Head-twitch response induced by ergometrine in mice: Behavioural evidence for direct stimulation of central 5-hydroxytryptamine receptors by ergometrine (1986)
    Springer
    Psychopharmacology 88 (1986), S. 275-278 
    Details
    ISSN: 1432-2072
    Keywords: Ergometrine ; 5-HT receptor antagonists ; Clomipramine ; p-Chlorophenylalanine ; p-Chloramphetamine ; Fenfluramine ; Head twitches ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ergometrine (2.5–80 mg/kg IP) induced head twitches in mice. Pretreatment with cyproheptadine (1.5 and 3 mg/kg), methysergide (5 and 10 mg/kg) and (−)-propranolol (2.5 and 5 mg/kg) significantly decreased the number of head twitches induced by ergometrine. Pretreatment with p-chlorophenylalanine (100 mg/kg/day×4 days) and clomipramine (5 and 10 mg/kg) significantly decreased the number of head twitches induced by fenfluramine (10 mg/kg) and p-chloramphetamine (5 mg/kg) but had no significant effect on the number of head twitches induced by ergometrine. The results indicate that ergometrine induces head twitches in mice by directly stimulating central 5-hydroxytryptamine receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180824
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Small doses of apomorphine induced catalepsy and antagonize methamphetamine stereotypy in rats (1982)
    Springer
    Psychopharmacology 78 (1982), S. 192-194 
    Details
    ISSN: 1432-2072
    Keywords: Apomorphine ; Molindone ; Methamphetamine ; Catalepsy ; Stereotypy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Small doses of apomorphine (AP, 31.25–125 μg/kg IP) induced dose-dependent catalepsy in rats. However. unlike the stereotyped behavior induced by high doses of AP which has a rapid onset and is short-lasting, the cataleptic effect induced by small doses of AP was evident 30 min after AP injection and was unusually long-lasting. Further, AP (31.25–125 μg/kg) administered 60 min before methamphetamine was found to significantly antagonize the methamphetamine-induced stereotyped behavior. Pretreatment with molindone (0.45 and 0.8 mg/kg IP), in doses reported to selectively block the presynaptic DA receptors, not only decreased the cataleptic effect of AP but also reversed the AP antagonism of methamphetamine stereotypy. The results suggest that small doses of AP induce catalepsy and antagonize methamphetamine stereotypy probably by an action at presynaptic DA receptor sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432262
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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