ISSN:
1432-2072
Keywords:
Ergometrine
;
5-HT receptor antagonists
;
Clomipramine
;
p-Chlorophenylalanine
;
p-Chloramphetamine
;
Fenfluramine
;
Head twitches
;
Mice
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Ergometrine (2.5–80 mg/kg IP) induced head twitches in mice. Pretreatment with cyproheptadine (1.5 and 3 mg/kg), methysergide (5 and 10 mg/kg) and (−)-propranolol (2.5 and 5 mg/kg) significantly decreased the number of head twitches induced by ergometrine. Pretreatment with p-chlorophenylalanine (100 mg/kg/day×4 days) and clomipramine (5 and 10 mg/kg) significantly decreased the number of head twitches induced by fenfluramine (10 mg/kg) and p-chloramphetamine (5 mg/kg) but had no significant effect on the number of head twitches induced by ergometrine. The results indicate that ergometrine induces head twitches in mice by directly stimulating central 5-hydroxytryptamine receptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00180824