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  • 1
    ISSN: 1432-1041
    Keywords: Diclofenac sodium ; gut ; manometry ; motility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In experimental animal models nonsteroidal anti-inflammatory drugs may influence gastrointestinal motility, but as evidence is lacking in man. The effect of diclofenac sodum 75 mg i.m. on the motor response of the upper gastrointestinal tract to food has been studied by manometry in 9 healthy volunteers. Diclofenac had no effect on the motor activity of the stomach, duodenum, or jejunum after a 605 kcal meal.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of radioanalytical and nuclear chemistry 194 (1995), S. 157-162 
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract There was concern that radioactivity might find its way into the food chain, namely fish, via low-level radioactive waste Ocean Dump Sites. This led the U.S. Food and Drug Administration, in collaboration with other Federal Agencies, to the monitoring and determination of radioactivity in fish samples from these Ocean Dump Sites. The radionuclide thought to be of major concern was plutonium-239/240. These sites were monitored at various periods from 1980. The sites were located off the coasts of New Jersey, California (near San Francisco) and Massachusetts Bay. The fish samples selected were shellfish that inhabited the ocean floor and bottom-feeders. The levels of activities required sophisticated measuring techniques since for plutonium-239/240, they were below the range. After a radiochemical procedure is used to separate the plutonium, it was measured using solid-state silicon detectors. These are coupled to a computer based multi-channel analyzer system. A plutonium-236 tracer is used to measure the recovery. The levels were found to be at background or in the 10 mBq range.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of radioanalytical and nuclear chemistry 236 (1998), S. 139-144 
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The U.S. Food and Drug Administration (FDA) is responsible for the wholesomeness of the nation's food supply. The FDA modified its food monitoring program in January, 1973, to include radioactive isotopes. The methodology used to perform, analyses on these food products are taken from the standerd setting societies such as the AOAC International, American Society for Testing Materials and American Public Health Association Standard Methods. In addition, methods not tested by these societies are taken from the literature or from Department of Energy manuals such as the Health and Safety Laboratory and also from Environmental Protection Agency, Public Health Service, and Food and Agricultural Organization manuals. These include the methods for long-lived radionuclides such as tritium, strontium-90, cesium-137 and plutonium. Also, the short-lived radionuclides such as iodine-131, radiocesium, radiocerium and radioruthenium. In addition, they include the natural occurring radionuclides such as radium and uranium isotopes. The activity concentrations of gamma-emitters such as radiocesium, iodine-131 and radioruthenium are determined by gamma-ray spectrometry. This is done using intrinsic germanium detectors with the appropriate hardware and software. The alpha and “pure” beta-emitters are determined by various radiochemical methods and techniques. The radiochemical methodology and equipment used in analyzing these radionuclides are described and discussed. Also, the methodology and equipment for the gamma-emitters are described in more detail in this paper. In addition, the limits of detection for the methods used will be discussed.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 352 (1995), S. 189-192 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The U.S. Food and Drug Administration (FDA) operates a whole-body counter at its's Winchester Engineering and Analytical Center (WEAC), Winchester, MA. This counter has been registered with the International Atomic Energy Agency (IAEA) and has been made available to others. The new requirements of the Nuclear Regulatory Commission (NRC) include internal dose exposure, using such a system. The whole-body counter performs thyroid scans for iodine-131 and also for iodine-125 and iodine-123. The latter requires thin-window germanium detectors (X-ray spectrometers). In addition, it has a large sodium iodine (Tl) crystal for whole body scans. One of the problems has been developing reference standards for energy and efficiency calibrations. Up to recently, only phantoms have been available to which the radioactive solution must be added. Lately, the Department of Energy has developed a “loan” program of phantoms containing specific radioactive isotopes in various configurations. This is expected to be added to this program to confirm the measurements. Software has also been developed which will calculate a 50 year dose commitment as required by the NRC for exposures. The use of these reference materials to assure that the system is in calibration is discussed.
    Type of Medium: Electronic Resource
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