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  • 1
    Electronic Resource
    Electronic Resource
    Structural and Magnetic Properties of Nanogranular BaTiO〈sub〉3〈/sub〉-CoFe〈sub〉2〈/sub〉O〈sub〉4〈/sub〉 Thin Films Deposited by Laser Ablation on Si/Pt Substrates (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 587-588 (June 2008), p. 303-307 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Thin film nanocomposites of cobalt ferrite (CoFe2O4) dispersed in barium titanate(BaTiO3) matrix, have been deposited with different cobalt ferrite concentrations (from 20% to 70%CoFe2O4), as well as pure barium titanate and cobalt ferrite thin films (end members). The filmswere prepared by pulsed laser ablation on platinum covered Si(001) substrates. The films structurewas studied by X-ray diffraction and their surface was examined by scanning electron microscopy(SEM). The magnetic properties were measured in a SQUID magnetometer. The results show thatthe deposited films are polycrystalline with a slight (111) barium titanate phase orientation and(311) CoFe2O4 phase orientation. The grain sizes measured from the X-ray diffraction peak widths,for both phases, are in the range 40nm to 100nm. However, as the concentration of the cobalt ferriteincreases, the grain size of the BaTiO3 phase decreases, from 100nm to 30nm, up to 40% CoFe2O4concentration beyond which the BaTiO3 grain size has an approximately constant value near 30nm.On the other hand the cobalt ferrite grain size does not show a clear trend with increasing cobaltferrite concentration, fluctuating in the range 20nm to 30nm. The magnetic measurements show anincrease of the magnetic moment from the low concentration region where the magnetic grains aremore isolated and their magnetic interaction is small, towards the bulk value at higher CoFe2O4concentrations. Also, a strong reduction of the magnetization with increasing temperature wasobserved, due to the corresponding decrease of the magnetocristalline anisotropy of the cobaltferrite
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/19/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.587-588.303.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Structural Characterization of Lead Metaniobate Thin Films Deposited by Pulsed Laser Ablation (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 514-516 (May 2006), p. 207-211 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The ferroelectric polymorph of lead metaniobate (PbNb2O6) presents an orthorhombic structure that is metastable at room temperature. This phase is obtained by quenching from high temperature. The fabrication of lead niobate thin films with this orthorhombic form has been reported to be difficult due to the presence of phases with the rhombohedric form or other nonstoichiometricphases. In this work, lead niobate thin films have been prepared by laser ablation, atdifferent oxygen pressures and with different substrate temperatures. Their structure was studied by X-ray diffraction and their surface was examined by scanning electron microscopy (SEM). The results show that for low deposition temperatures the films presented a rhombohedric-PbNb2O6 structural phase. As Tdep increases the films started to develop an orthorhombic- PbNb2O6 structurethat appeared at 400ºC and remains up to 600ºC. For lower oxygen pressure during deposition, a mixture of this phase and other orthorhombic lead deficient phases are present in the films. On the other hand, by increasing the oxygen pressure the lead deficient phases are strongly reduced and the films present only the orthorhombic- PbNb2O6 structure
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/12/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.514-516.207.pdf
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  • 3
    facet.materialart.
    Unknown
    ¿Puede hablarse de una cultura y y en especial de una Filosofía del Renacimiento? (1944)
    Madrid : Periodicals Archive Online (PAO)
    Revista de filosofía. 3:8 (1944:enero/marzo) 97 
    Details
    ISSN: 0034-8244
    Topics: Philosophy
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:4174-1944-003-08-000003
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  • 4
    facet.materialart.
    Unknown
    ¿Puede hablarse de una cultura, y en especial de una Filosofía del Renacimiento? (1944)
    Madrid : Periodicals Archive Online (PAO)
    Revista de filosofía. 3:9 (1944:abr./jun.) 267 
    Details
    ISSN: 0034-8244
    Topics: Philosophy
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:4174-1944-003-09-000003
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  • 5
    Electronic Resource
    Electronic Resource
    Pharmacokinetic approach to the selection of dose schedules for medroxyprogesterone acetate in clinical oncology (1982)
    Springer
    Cancer chemotherapy and pharmacology 8 (1982), S. 151-156 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pharmacokinetic and bioavailability properties of medroxyprogesterone acetate (MPA) after single PO and IM doses in man were used as a basis to predict, on a theoretical pharmacokinetic basis, the blood level profile of the drug during repeated dose administration with various dosage schedules. Because of the unusually long-lasting depot effect of IM MPA, a different build-up process of blood levels is expected during repeated IM or PO administration, and this should be taken into account when dose schedules for use in clinical oncology are selected. As regards the IM route, dose schedules based on 4 weeks' treatment with daily injections of 500–1,000 mg followed by a maintenance therapy with 1,000 mg/week are suggested, since they permit rapid achievement and maintenance of relatively high plasma levels. A similar plasma level profile can be obtained with oral MPA provided that daily doses twice as large as the IM doses are given during the first month of treatment and continued during the maintenance period. The serum levels observed in 25 patients with advanced breast cancer treated with MPA given IM or PO according to various dose schedules and recent literature data are very close to the serum level profiles predicted on a theoretical pharmacokinetic basis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00255475
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  • 6
    Electronic Resource
    Electronic Resource
    Identification of hazelnut (Corylus avellana) cultivars by RAPD analysis (1999)
    Springer
    Plant cell reports 18 (1999), S. 652-655 
    Details
    ISSN: 1432-203X
    Keywords: Key words PCR ; RAPD analysis ; Corylus avellana ; Cultivars
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The random amplified polymorphic DNA (RAPD) technique offers a useful tool to detect DNA polymorphisms. It can also be used to distinguish different clones and cultivars. We have developed a comprehensive RAPD-based procedure for the routine molecular typing of various plants. Here we report the application of this technique for the correct identification of six hazelnut cultivars (Corylus avellana) widespread in the Campania region (south Italy). The analysed hazelnut cultivars were successfully distinguished by their RAPD fingerprints using the DNA primers U2, U3, U4, U11 and U14. However, in each cultivar we observed very low genetic heterogeneity among the clonal variants. Since this technique is among the simplest and easiest methods used to fingerprint DNA, it could be easily transferred to less sophisticated laboratory infrastructures (e.g. outstations of crop regulatory agencies).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002990050637
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  • 7
    Electronic Resource
    Electronic Resource
    Complications of pediatric laparoscopic surgery (1997)
    Springer
    Surgical endoscopy and other interventional techniques 11 (1997), S. 655 -657 
    Details
    ISSN: 1432-2218
    Keywords: Key words: Laparoscopy — Complications — Open approach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Surgical complications of laparoscopy most often occur during Veress needle or primary trocar placement. Veress needle punctures are insignificant and require no further treatment, whereas trocar-induced vascular injuries can be catastrophic. The frequency of vascular and viscus injuries is difficult to calculate because several complications are not reported in the literature. Methods: During a 10-year-period (1984–1995), at the Division of Pediatric Surgery at ``Federico II'' University of Naples, 430 laparoscopic procedures were performed in 395 children with a mean age of 5 years. The incidence of complications related to laparoscopy was 1.8% with eight complications, one of which was rather severe. The complications included one abdominal wall hematoma, two perforations of abdominal viscus (stomach, ovary), one umbilical scar complication, one postoperative hydrocele, one subcutaneous emphysema, and one pneumothorax during a Nissen procedure. The only severe complication occurred in a young girl with neurologic problems and a kyphoscoliosis operated on via laparoscopy for a gastroesophageal reflux. She suffered injuries of both right common iliac vessels and several intestinal perforations due to blind introduction of the first umbilical trocar. Results: In this case rapid conversion, complex vascular reconstruction, and multiple intestinal sutures were performed. The Nissen fundoplication with pyloroplasty was performed traditionally and the patient left the hospital free of symptoms after 20 days. The other seven complications were resolved without any problem intra- or postoperatively. Conclusions: The authors believe that the open approach with a blunt trocar is most important in helping to avoid complications in pediatric laparoscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004649900415
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  • 8
    Electronic Resource
    Electronic Resource
    5-Fluorouracil plus interferon α-2a compared to 5-fluorouracil alone in the treatment of advanced colon carcinoma: A multicentric randomized study (1998)
    Springer
    Journal of cancer research and clinical oncology 124 (1998), S. 191-198 
    Details
    ISSN: 1432-1335
    Keywords: Key words Advanced colon cancer  ;  Biochemical modulation  ;  5-Fluorouracil  ;  Immunotherapy  ;   Interferon α-2a
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Biochemical modulation is one of the most interesting fields in cancer chemotherapy. Interferon-α (IFNα) is a cytokine that is able to influence the pharmacodynamics of 5-fluorouracil (5FU) through a number of mechanisms. With the aim of confirming some data emerging from the literature, we initiated a multicentric randomized study comparing the combination of 5FU and IFNα-2a with 5FU alone in the treatment of advanced or metastatic colon cancer. A group of 205 colon cancer patients (104 in the 5FU arm and 101 in the 5FU+IFNα-2a arm) were included in the final intention-to-treat analysis. Rectal cancers were not considered eligible. All patients had measurable disease, were aged 75 years or less, had a Karnofsky index of at least 60 and had good bone marrow, renal, liver and cardiac functions. No previous chemo-immunotherapy was allowed. The treatment was 750 mg/m2 5FU (4 h i.v. infusion) on days 1–5 and then i.v. bolus weekly, starting from day 12, with or without IFNα-2a given s.c. three times weekly (starting dose 3 × 106 IU rising to 9 × 106 IU, if tolerated). Patients were treated until progression or, if responsive, for a maximum of 48 weeks and then observed for a period of 2 years. The primary end-point of the study was objective clinical response (OR); secondary parameters were time to progression, overall survival, and time to death after progression. WHO criteria were used for both clinical response and toxicity measurements. Dose reduction was planned a priori in the event of significant toxicity due to 5FU, IFNα-2a or both. Association between primary and secondary end-points and treatment was studied by univariate and multivariate analysis. Altogether, 47 patients achieved a documented response. A 25% OR was observed in the combination arm while a 21% OR was seen in the 5FU arm; this difference is not statistically significant (P=0.6). Patients with a small tumour burden (below 5 cm2) showed a higher probability of response in both arms. Patients in the experimental arm had a higher but not statistically significant cumulative progression-free probability. Median survival was 47.1 weeks overall, while it was 43.7 and 48.5 weeks in the control and experimental arms, respectively. The combination was clearly more toxic than 5FU alone, leukopenia being the most frequent side-effect in the experimental arm and nausea and vomiting in the control arm. In conclusion these results are quite disappointing and 5FU + IFNα-2a can not be considered a standard treatment for advanced colon cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004320050154
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  • 9
    Electronic Resource
    Electronic Resource
    Induction chemotherapy by superselective intra-arterial high-dose carboplatin infusion for head and neck cancer (2000)
    Springer
    European archives of oto-rhino-laryngology and head & neck 257 (2000), S. 279-282 
    Details
    ISSN: 1434-4726
    Keywords: Key words Head and neck cancer ; Intra-arterial ¶chemotherapy ; Carboplatin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the feasibility, maximum dose of drug tolerated, technical problems, systemic and local toxicity, response rate, overall and disease-free survival, we studied superselective intra-arterial infusion of high-dose carboplatin as part of a multimodality treatment for head and neck cancer. Forty patients with untreated stage II–IV head and neck squamous cell carcinomas received induction chemotherapy with high-dose carboplatin (three cycles at 2-week intervals using 300–350 mg/m2 per cycle), delivered via superselective transfemoral angiography followed by radiotherapy or surgery plus radiotherapy. No technical complications occurred during or after the infusion. Systemic toxicity was minimal, and local toxicity was moderate. At the end of chemotherapy the overall complete and partial response rate was 90% (36/40) at the primary site and 64% (16/25) at the neck nodes. The median follow-up was 24.4 months (range 3–52). To date 21 patients are alive without disease, 2 are alive with disease, 13 have died of disease, and 4 have developed a metachronous lung tumor. There was a good correlation between the response to chemotherapy and disease-free survival. No statistically significant benefit in survival was observed with respect to other series of head and neck tumors treated with different protocols. However, discriminating between responding and nonresponding patients, this procedure can have a prognostic significance in planning integrated treatments for these types of tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004050050240
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  • 10
    Electronic Resource
    Electronic Resource
    A CMOS steering-current multiplying digital-to-analog converter (1995)
    Springer
    Analog integrated circuits and signal processing 8 (1995), S. 145-155 
    Details
    ISSN: 1573-1979
    Keywords: digital-to-analog conversion ; CMOS steering-current techniques ; multiplying functions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract This paper discusses the design and integrated circuit implementation of two alternative solutions for realizing an 8-bit high-speed steering-current multiplying digital-to-analog converter based on a current-source-array architecture. In the first solution, designated as voltage-controlled-current-source operation, a reference voltage is used to drive directly the gate-to-source voltage of the current-sources while in the second solution, designated as geometry-programmable-current-source operation, the current-sources are generated using a digitally programmable transistor-array. The characteristics of both solutions are discussed from the viewpoints of the accuracy and distortion introduced by the multiplying function. For demonstration purposes a prototype chip suitable for both operating modes has been fabricated in a single-poly 1.2µm CMOS digital technology. At 5 V supply and 13.3 mA full-scale output current, the chip dissipates about 90 mW for a sampling frequency of 50 MHz. The die area is approximately 1.75 mm2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01239107
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