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  • 1
    facet.materialart.
    Unknown
    Berlin : Periodicals Archive Online (PAO)
    Deutsche Zeitschrift für Philosophie. 23:6 (1975) 842 
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  • 2
    facet.materialart.
    Unknown
    Paris : Periodicals Archive Online (PAO)
    Etudes anglaises. 26:1 (1973:janv./mars) 49 
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  • 3
    facet.materialart.
    Unknown
    Paris : Periodicals Archive Online (PAO)
    Revue de littérature comparée. 44:2 (1970:avril/juin) 215 
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 95 (1979), S. 147-157 
    ISSN: 1432-1335
    Keywords: Chlorambucil ; Bleomycin ; Metallocene ; Cytostatika ; Intratumoral ; Chlorambucil ; Bleomycin ; Metallocen ; Cytostatica ; intratumoral
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Cytostatika Chlorambucil und Bleomycin wurden mit 131J bzw. 57Co markiert, Ruthenocenaldehyd-(N-methyl-N β-chloräthyl)-hydrazo und Ruthenocen-3-phenyl-prop-1-en-3-on mit dem γ-Strahler 103Ru. Diese radioaktiven Modell-Substanzen wurden Tumor-tragenden Mäusen intravenös und intratumoral injiziert und anschließend Exkretion und Organ-Verteilung gemessen. Nach intratumoraler (i.t.) Injektion war die Konzentration im Tumor langanhaltend höher und in den übrigen Organen niedriger als nach i.v.-Injektion. Die im Zeitraum 1–24 Std post inj. dem Tumorgebiet zur Verfügung stehenden Dosen (Integration der Konzentrations-Zeit-Kurven) sind bei i.t.-Injektion 10–80 mal höher als nach i.v. Gabe.
    Notes: Summary The cytostatic drugs Chlorambucil and Bleomycin were labeled with 131I and with 57Co, respectively; Ruthenocenealdehyde-(N-methyl-N-β-chlorethyl)-hydrazone and Ruthencoene-3-phenyl-prop.1-en-3-one were labelled with the γ-emitter 103Ru. In tumor-bearing mice the elimination and organ distribution of these radioactive substances were tested after intravenous (i.v.) and intratumoral (i.t.) injection of the drugs. The organ load showed lower values after i.t. than after i.v. application, while the radioactivity concentrations in the tumor were considerably increased after i.t. injection. The integrals of the concentration-time curves showed 10–80 times higher concentrations in the tumor after i.t. compared to i.v. injection of the drugs.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Mund-, Kiefer- und Gesichtschirurgie 3 (1999), S. 338-341 
    ISSN: 1434-3940
    Keywords: Schlüsselwörter Orbitaepithese ; Kraniofaziales Implantat ; Retinoblastom ; Key words Facial prosthesis ; Craniofacial implant ; Retinoblastoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary From the aesthetic point of view, a patient can be completely rehabilitated after the loss of an eye with the insertion of an artificial eye made of glass. If the delicate structures of the eyelids have been severely damaged, however, or if the eye socket does not provide adequate retention for an eye prosthesis, rehabilitation becomes more difficult, and sometimes cannot be achieved with a cosmetically satisfactory result. In such cases, a facial prosthesis offers an alternative solution. Stable retention can be ensured with craniofacial implants. Single-sided rehabilitation by this method is quite common, but bilateral treatment is a rarity. We report on the prosthetic rehabilitation of a patient after exenteration on both sides due to retinoblastomas.
    Notes: Zusammenfassung Ein Patient kann nach Verlust seines Auges in der Regel durch Eingliederung einer Augenprothese aus Glas ästhetisch vollständig rehabilitiert werden. Bei starker Alteration der filigranen Strukturen der Lider oder des Augenprothesenlagers wird die Versorgung schwieriger, so daß manchmal kein kosmetisch befriedigendes Ergebnis erreichbar ist. Hier bietet sich die Rehabilitation mit einer Orbitaepithese als Alternative an. Ein sicherer Halt erfolgt über kraniofaziale Implantate. Während die einseitige Rehabilitation häufiger durchgeführt wird, ist eine doppelseitige Versorgung eine Rarität. Hier wird von einem solchen Fall nach doppelseitiger Augenentfernung und epithetischer Rehabilitation aufgrund von beidseitig aufgetretenen Retinoblastomen berichtet.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Mund-, Kiefer- und Gesichtschirurgie 2 (1998), S. 106-107 
    ISSN: 1434-3940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Mund-, Kiefer- und Gesichtschirurgie 4 (2000), S. 391-394 
    ISSN: 1434-3940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Der Onkologe 3 (1997), S. 154-156 
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 201 (1972), S. 147-158 
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Blinzelreaktion der Lider als Antwort auf akustische Reize (Weißes Rauschen) wurde an 68 Versuchspersonen untersucht. Bestimmt wurden die Reflexschwellen und die Reflexzeiten. Es ergab rich, daß die Reflexschwelle eine Funktion der Horschwelle ist and etwa 30 dB über der Horschwelle liegt. Innerhalb der untersuchten Altersgruppen ist die Reizschwelle bei Kindern im Alter von 5–6 Jahren am niedrigsten and steigt bis zum Lebensalter von über 60 Jahren kontinuierlich an. Die Reflexzeiten betragen minimal 38-40 msec, können aber auf 150 msec and mehr ansteigen. Schwelle and Latenz des Reflexes zeigen eine Abhängigkeit von der Dauer des Reizschalles. Der Verlauf der Schwellenwerte und der Reflexzeiten in Abhängigkeit von der Reizdauer weist darauf hin, daß die physikalischen Eigenschaften des Receptororgans (vermutlich Einschwingvorgänge) hier eine entscheidende Rolle spielen. Nach unseren Befunden stellt die Auslösung des cochleo-palpebralen Reflexes eine nicht aufwendige and brauchbare Methode zur objektiven Audiometrie dar. Alterdings ist einschränkend zu erwähnen, daß der Blinzelreflex bei 100/0 der Versuchspersonen nicht ausgelöst werden konnte.
    Notes: Summary The blink reflex elicited by auditory stimulation was evaluated in a total 68 healthy individuals. This group included 8 children, 5 to 6 years old, and 50 adults which were distributed with age in the following manner: 20–30 years (37), 40–50 years (7), 50–60 years (8), and over 60 (8). White-noise signals were employed varying in duration between 10 and 200 msec. The response of the m. orbiculris orbis was electromyographically recorded. Threshold levels were lowest in the youngest age group, with intensities ranging from 15 to 20 dB SPL and for signal durations of 200 msec. For shorter durations, however, threshold levels increased in essentially the same manner as loudness decreases under the same condition as was originally observed by v. Békésy with aid of conventional audiometric techniques. With age, threshold became elevated, but ratios between subjective, Auddometric, thresholds and reflex thresholds remained essentially constant, i.e., 30 dB for signal durations of 200 msec. At intensities much higher than threshold levels, the latency of the blink reflex was 38.5–39.3 msec, while for intensities only slightly exceeding threshold levels latencies as long as 118–150 msec were measured. The cochleo-palpebral reflex parallels peripheral auditory function in two respects, (a) as regards the effect of signal duration upon threshold values, and (b ) as regards the effect of signal intensity upon response latencies. In 10% of subjects tested, the reflex could not be elicited.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 235 (1982), S. 413-415 
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Distribution experiments using 57Co-bleomycin and therapeutic experiments with non-labelled bleomycin were carried out in strain two guinea pigs with 7 day old intradermally growing line ten tumors which already showed signs of lymphogenous metastasis. Labeled and non-labeled bleomycin was applied i.v. (aqueous solution) and intratumorally (aqueous solution, oil suspension, oil emulsion). Intratumoral application of bleomycin emulsion showed in comparison to all other tested variants the highest activities in the tumor and in the draining lymph nodes and the best therapeutic results. On the basis of these experimental findings a clinical study was started. Patients with inoperable squamous cell carcinomas of the head and neck were treated by intralesional application of bleomycin emulsion. Under this type of therapy partial and complete tumor remission could be observed.
    Type of Medium: Electronic Resource
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