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  • 1
    Electronic Resource
    Electronic Resource
    Infrequent but significant p21/WAF1/CIP1 gene alteration in synchronous or metachronous transitional cell carcinoma (1996)
    Springer
    Apoptosis 1 (1996), S. 69-74 
    Details
    ISSN: 1573-675X
    Keywords: p21/WAF1/CIP1 ; p53 ; LOH of the p21 gene ; PCR-SSCP analysis ; synchronous or metachronous transitional cell carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract p53 inducible cyclin dependent kinase inhibitor, p21/WAF1/CIP1(p21), played a pivotal role for G1 arrest when cells received genotoxic stimuli. p21 could be a putative tumor suppressor gene, since its dysfunction may lead to accumulation of genomic alteration. We investigated the p21 and p53 status using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and immunohistochemical analyses, in eight patients who had synchronous or metachronous urothelial tumors. Loss of heterozygosity (LOH) of p21 gene was detected in one coincidental tumor in one case. p21 positive cells were detected by immuno-histochemical staining in all tumors in one case, and in one coincidental tumor in two cases. Among p21 positive cells in these three cases, no p53 mutations were detected, whereas no p21 positive cells were detected in other cases with a p53 mutation. These findings suggested that in transitional cell carcinoma (TCC) p21 gene mutation is infrequent like the p53 gene mutation, but that LOH might be important in the inactivation of p21.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00142080
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Upregulation of Fas-induced apoptosis by interferon-γ accompanied by increased ICE expression in renal cell cancer cells (1996)
    Springer
    Apoptosis 1 (1996), S. 209-212 
    Details
    ISSN: 1573-675X
    Keywords: Apoptosis ; Fas ; interferon-γ ; renal cell cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The integration of Fas/Apo-1 (CD95) by Fas ligand or anti-Fas antibody induces apoptosis, and this system plays a pivotal role for the lysis of target cells by cytotoxic T lymphocytes. Fas-mediated apoptosis is also increased by a prior incubation of Fas-bearing cells with interferon(IFN)-γ. Interleukin-1-β converting enzyme (ICE) and/or CPP32, or other members of ICE family act as direct cell death executors downstream of this mechanism, and a tetrapeptide inhibitor of these cysteine proteases blocks Fas-mediated apoptosis. In this study, we examined the effect of IFN-γ on Fas-mediated apoptosis in ACHN cells. IFN-γ augmented apoptosis in a dose dependent manner and reached a plateau at 400 U/ml when exposed for 48 h before the end of culture. The kinetics revealed a significant increase in apoptosis after 24 h. Exposing ACHN cells to IFN-γ increased pro-ICE expression accompanied with a decrease of pro-CPP32. These results suggest that direct enhancement of ICE expression and/or upregulation of conversion of pro-CPP32 to active form increases Fas-mediated apoptosis by IFN-γ in ACHN cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01321104
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Adriamycin (ADM) induced apoptosis in Transitional Cell Cancer (TCC) cell lines accompanied by p21 WAF1/CIP1 induction (1997)
    Springer
    Apoptosis 2 (1997), S. 207-213 
    Details
    ISSN: 1573-675X
    Keywords: Adriamycin (ADM) ; apoptosis ; Bax ; Bcl-2 ; p21WAF1/CIP1 ; p53 ; Transitional Cell Cancer (TCC)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Genotoxic stimuli, including anticancer drugs, induce apoptosis in cancer cells through increase of p53, p21WAF1/CIP1 , at least in part. Bcl-2 and Bax modify this pathway or directly regulated by p53. Here we studied Adriamycin (ADM)-induced apoptosis in four human bladder cancer cell lines in respect of p53, p21WAF1/CIP1 and Bcl-2 family proteins. After ADM, treatment bladder cancer cells underwent dose-dependent cell death with typical morphologic features of apoptosis. Among four cell lines RT4 with wt p53, low ratio of Bcl-2 to Bax and induction of p21WAF1/CIP1 after ADM treatment, was the most sensitive to induction of apoptosis. Thus, p53, p21WAF1/CIP1 , Bcl-2 and Bax status might determine susceptibility of bladder cancer cells to ADM induced apoptosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026472700554
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Mechanized welding of a christmas tree of 06Kh20N8M3D2L steel (1985)
    Springer
    Chemical and petroleum engineering 21 (1985), S. 365-367 
    Details
    ISSN: 1573-8329
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01149672
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  • 5
    Electronic Resource
    Electronic Resource
    Gating processes in Na-channel of biological membrane from the standpoint of superionic phase transition (1998)
    Springer
    Ionics 4 (1998), S. 82-87 
    Details
    ISSN: 1862-0760
    Keywords: superionic phase transition ; gating process ; ion channel ; membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The method of condensed matter physics is applied to reason out the problem of Na transport through a biological membrane. A similiarity of gating process in Na ion channel to the superionic phase transition is discussed. A possible microscopic mechanism is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02375783
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    Paper (German National Licenses)
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