ISSN:
1432-1912
Keywords:
Brocresine
;
Diamine Oxidase
;
Rat
;
Plasma
;
Liver
;
Stomach
;
Small Intestine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary 1. In male rats DAO was found to be absent in plasma and liver, very low in gastric and high in the upper small intestinal mucosa. 2. Gastric mucosal DAO was completely abolished by 10−8 M Brocresine. In the small intestine inhibition of DAO by Brocresine was dose-dependent, with a concentration of 6.2×10−6 M producing a 50% inhibition of the enzyme. 3. Pretreatment of rats with 100 mg/kg Brocresine i.p. produced a 43% inhibition of DAO after 1 h and an insignificant inhibition by 20% after 4 h. 4. The results suggest that the histidine decarboxylase inhibitor Brocresine is not a very suitable tool for studying the physiological role of histamine by inhibiting its biosynthesis since it also interferes with the histamine catabolism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00501484
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