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  • 1
    Electronic Resource
    Electronic Resource
    Effect of aluminum phosphate on the bioavailability of ranitidine (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 97-99 
    Details
    ISSN: 1432-1041
    Keywords: ranitidine ; aluminium phosphate ; antacids ; bioavailability ; drug interaction ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of aluminum phosphate on the bioavailability of ranitidine has been investigated in 10 young, healthy volunteers. Following a random cross over design, each subject took at a 1 week interval 150 mg ranitidine alone or with 11 g aluminum phosphate. Plasma and urine ranitidine levels were measured by HPLC. The antacid reduced both the maximum plasma ranitidine concentration by 40% and the area under the curve by 30%. Elimination of ranitidine was not changed. The results indicate that aluminum phosphate significantly diminished the bioavailability of ranitidine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609966
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of josamycin on carbamazepine kinetics (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 321-323 
    Details
    ISSN: 1432-1041
    Keywords: carbamazepine ; josamycin ; drug interaction ; epileptic patients ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The steady state pharmacokinetics of oral carbamazepine in epileptic patients (n=8) was compared before and after one week of treatment with josamycin (2 g/day). There was a small but statistically significant decrease in oral clearance of total (17%) and unbound (21.5%) drug. In spite of an unchanged AUC of 10,11-epoxide carbamazepine the ratio of metabolite to parent drug AUC was significantly decreased (20.2%). The plasma protein binding of carbamazepine and its 10,11-epoxide metabolite did not vary. The results demonstrate impairment by josamycin of the apparent clearance of carbamazepine. Care should be taken in patient receiving both carbamazepine and josamycin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607583
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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