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  • 1
    Digitale Medien
    Digitale Medien
    Effects of josamycin on carbamazepine kinetics (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 321-323 
    Details
    ISSN: 1432-1041
    Schlagwort(e): carbamazepine ; josamycin ; drug interaction ; epileptic patients ; pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The steady state pharmacokinetics of oral carbamazepine in epileptic patients (n=8) was compared before and after one week of treatment with josamycin (2 g/day). There was a small but statistically significant decrease in oral clearance of total (17%) and unbound (21.5%) drug. In spite of an unchanged AUC of 10,11-epoxide carbamazepine the ratio of metabolite to parent drug AUC was significantly decreased (20.2%). The plasma protein binding of carbamazepine and its 10,11-epoxide metabolite did not vary. The results demonstrate impairment by josamycin of the apparent clearance of carbamazepine. Care should be taken in patient receiving both carbamazepine and josamycin.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00607583
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Effect of aluminum phosphate on the bioavailability of ranitidine (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 97-99 
    Details
    ISSN: 1432-1041
    Schlagwort(e): ranitidine ; aluminium phosphate ; antacids ; bioavailability ; drug interaction ; healthy volunteers
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The effect of aluminum phosphate on the bioavailability of ranitidine has been investigated in 10 young, healthy volunteers. Following a random cross over design, each subject took at a 1 week interval 150 mg ranitidine alone or with 11 g aluminum phosphate. Plasma and urine ranitidine levels were measured by HPLC. The antacid reduced both the maximum plasma ranitidine concentration by 40% and the area under the curve by 30%. Elimination of ranitidine was not changed. The results indicate that aluminum phosphate significantly diminished the bioavailability of ranitidine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00609966
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
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