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  • 1
    Electronic Resource
    Electronic Resource
    Thrombosis of the Galenic system veins in the adult (1971)
    Springer
    Acta neuropathologica 17 (1971), S. 227-233 
    Details
    ISSN: 1432-0533
    Keywords: Venous Thrombosis ; Galenic System ; Terminal Veins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Drei Fälle von Thrombose der Vena magna Galeni werden veröffentlicht. Keine Thrombose anderer Venen oder Sinus durales war vorhanden. Alle drei Fälle waren Frauen. Bei einer Patientin berichtete die Anamnese den Gebrauch eines oralen Kontraceptivum (Lyndiol®). Bei einer anderen traten die Symptome nach Gebrauch von Amitriptylinepamoat (Tryptizol®) auf. Die dritte Patientin litt an Polycytämie, bei der die Thrombose nach Schädelfraktur auftrat. In der Literatur des letzten Jahrhunderts sind keine anderen Fälle verzeichnet, vermutlich weil die klinische Diagnose sehr schweirig ist.
    Notes: Summary Three cases of thrombosis of the Galenic system veins in adults are presented. Thrombosis of other veins or the venous sinuses was not found. All three patients were women, only one of whom used oral contraception (Lyndiol®). In another of these cases treatment with amitriptylinepamoate (Tryptizol®) seemed to have initiated the symptoms. In the third case, a patient with polycythaemia, the thrombosis developed after a cranial fracture. No other cases of this kind are reported in the literature of this century.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685056
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  • 2
    Electronic Resource
    Electronic Resource
    Traumatic thrombosis of intracranial arteries and extensive necrosis of the brain developed during reanimation (1964)
    Springer
    Acta neuropathologica 3 (1964), S. 416-427 
    Details
    ISSN: 1432-0533
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Krankengeschichten von 4 Patienten mit schwerer cranio-cerebraler Verletzung werden mitgeteilt. Die klinischen Bilder sowie die autoptischen Befunde zeigten starke Ähnlichkeit. Der klinische Verlauf konnte in 3 verschiedene Perioden gegliedert werden und zwar: 1. von dem Auftreten der Verletzung bis zum Einsetzen der künstlichen Beatmung, 2. von diesem Zeitpunkt bis zum klinischen Tod des Gehirns und schließlich 3. bis zum totalen Tod. Bei der autoptischen Untersuchung waren die Gehirne auffallend weich und bröckelig. Die mikroskopische Untersuchung deckte Nekrosen sowohl der grauen als auch der weißen Substanz des gesamten Gehirns auf. Diese wurden auf eine intravitae Autolyse zurückgeführt. Obgleich der Tod 4–9 Tage nach der Hirnschädigung eintrat, waren die primären Läsionen (durch die Verletzung selbst) nicht von normalen Leukocyten- oder Gliazellreaktionen begleitet. Eine sehr interessante Tatsache war eine in allen 4 Fällen manifestierte ausgedehnte frische Thrombose der carotico-basilaren Arterien. Diese Thrombosen rührten von traumatischen Gefäßwandläsionen im Zusammenhang mit Blutstauungen her, die durch lokale Vasoparalyse und generelle Hypotension hervorgerufen worden waren. Möglicherweise ist die ungewöhnliche Ausdehnung der intraarteriellen Thrombose nur auf das künstliche Überleben des Pat. zurückzuführen. Es erhebt sich das Problem, ob der intravitale Tod des Gehirns eine Folge der Thrombose ist oder aber ob die Thrombose sich während des Deanimationsstadiums ausgebildet hat.
    Notes: Summary The case histories of 4 patients with a severe cranio-cerebral injury were described. The clinical pictures and the post mortem findings showed much resemblance. The clinical course was divided into three different periods: The first lasting from the injury till the moment of artificial respiration, the second from then on till the clinical evidence of death of the brain and the third from then on till death. On post mortem examination the brains were remarkably soft and friable. Microscopic examination revealed necrosis of both the grey and white matter of the whole brain. It was supposed that this was due to intravital autolysis. Although death followed 4–9 days after the brain accident, the primary lesions (caused by the injury itself) were not accompained by a normal reaction of leucocytes or glia cells. A most interesting feature in all four cases was a very extensive and recent thrombosis of the carotico-basilar arteries. This thrombosis was the result of traumatic lesions of the vessel wall in combination with stasis of the blood caused by local vasoparalysis and general hypotension. It is likely that the unusual extent of the intra-arterial thrombosis was only possible thanks to the artificial survival of the patient. The problem arises whether the intravital death of the brain was the result of the thrombosis or whether the thrombosis developed during the state of deanimation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688452
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  • 3
    Electronic Resource
    Electronic Resource
    Angioendotheliomatosis of the central nervous system (1974)
    Springer
    Acta neuropathologica 28 (1974), S. 75-78 
    Details
    ISSN: 1432-0533
    Keywords: Angioendotheliomatosis ; Vascular Endothelium ; Neoplastic Growth ; Inflammatory Reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of angioendotheliomatosis is described in which the neoplastic proliferation of the vascular endothelium was restricted to the central nervous system. Although the process resembled a malignant tumour, neoplastic growth did not occur outside the blood vessels. The process was accompanied by a chronic inflammatory reaction in and around the blood vessels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687520
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  • 4
    Electronic Resource
    Electronic Resource
    Neuropathological changes of the nucleus accumbens in Huntington's chorea (1981)
    Springer
    Acta neuropathologica 55 (1981), S. 21-22 
    Details
    ISSN: 1432-0533
    Keywords: Huntington's chorea ; Nucleus accumbens ; Nuclear membrane indentation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ultrastructural analysis of the ncl. accumbens, frontal cortex, and caudate nucleus of ten patients with Huntington's chorea revealed nuclear membrane indentation of remaining neuronal elements in 〉25%, 〈5%, and 〈2%, respectively. This phenomenon was not observed in ten non-choreic control brains obtained from patients with Alzheimer's disease, Parkinson's disease, and non-demented elderly people. The pathogenetic mechanisms leading to this phenomenon are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691525
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  • 5
    Electronic Resource
    Electronic Resource
    Virus-like particles in brain tissue from two patients with Creutzfeldt-Jakob disease (1971)
    Springer
    Acta neuropathologica 18 (1971), S. 267-270 
    Details
    ISSN: 1432-0533
    Keywords: Virus-Like Particles ; Creutzfeldt-Jakob Disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Virusähnliche Partikel wurden in Gehirnbiopsien von zwei Patienten mit Creutzfeldt-Jakobscher Krankheit beobachtet. Diese Partikel fanden sich fast ausschließlich im Cytoplasma von Astrocyten, die eine Konzentration von Gliafilamenten, Schwellung oder sogar Desintegration zeigten.
    Notes: Summary Particles resembling virions observed in brain biopsies of two patients with Creutzfeldt-Jakob disease were located almost exclusively in the cytoplasm of the astrocytes which were swollen and showed accumulations of glia fibres, sometimes the cell bodies of the astrocytes were destroyed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685073
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  • 6
    Electronic Resource
    Electronic Resource
    The influence of preoperative administration of methotrexate on the outgrowth of meningiomas and astrocytomas in tissue culture (1980)
    Springer
    Acta neurochirurgica 54 (1980), S. 201-204 
    Details
    ISSN: 0942-0940
    Keywords: Tissue culture ; meningiomas ; astrocytoma ; methotrexate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Explants from 30 human meningiomas and 29 human malignant astrocytomas (i.e., glioblastomas multiforme) were grown in tissue culture for four weeks. After preoperative administration of 50 mg methotrexate (MTX) to the patients outgrowth of the meningiomas in tissue culture was markedly inhibited, but a similar effect was not seen for the astrocytomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01407086
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  • 7
    Electronic Resource
    Electronic Resource
    An intrasellar cyst with both Rathke's cleft and epidermoid characteristics (1980)
    Springer
    Acta neurochirurgica 51 (1980), S. 203-207 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of an intrasellar cyst in a 48-year-old woman is reported. The cyst was lined by stratified squamous epithelium, most of which was covered by ciliated columnar epithelium. Most of the stratified squamous epithelium showed necrosis accompanied by signs of an acute inflammatory reaction. After surgical resection aseptic meningitis developed. The lumbar CSF findings were still abnormal four months after the operation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01406746
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  • 8
    Electronic Resource
    Electronic Resource
    Influence of Adrenocorticotrophic Hormone, Hydrocortisone and Hypophysectomy on the Distribution of β-Glucuronidase in the Adrenal Cortex of the Rat (1963)
    [s.l.] : Nature Publishing Group
    Nature 200 (1963), S. 1111-1112 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Four groups of animals.were examined. Each group consisted of 5 males and 5-feniales weighing 150 g : group I, control animals ; group II, animals receiving 2 I.U. ACTH daily for 10 days, subcutaneously; group III, animals receiving 2 mg hydrocortisone daily for 10 days, subcutaneously; group IV, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2001111a0
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  • 9
    Electronic Resource
    Electronic Resource
    Differential Expression of Endothelium-specific Antigen PAL-E in Vasculature of Brain Tumors and Preexistent Brain Capillaries (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 529 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb51434.x
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  • 10
    Electronic Resource
    Electronic Resource
    Proliferation of blood vessels and stroma in brain tumours (1976)
    Springer
    Virchows Archiv 372 (1976), S. 175-182 
    Details
    ISSN: 1432-2307
    Keywords: Endothelial proliferations ; Enzyme-histochemistry ; Influx of monocytes ; Oedema of brain tumours
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Proliferation of the vascular endothelium occurring in brain tumours is accompanied by a proliferation of histiocytes in the peripheral part of the vessel wall. These histiocytes infiltrate the tumour tissue in a very regular pattern. Enzyme-histochemically, there are marked differences between the activities of alkaline phosphatase, 5-nucleotidase, and ATPase in the normal and proliferating blood vessels. The whole process encompasses reactive changes evoked by the destroyed perivascular sheath of astroglial foot processes and the subsequent oedema in the tumour and the surrounding parenchyma. There are often tumour areas where diminished vascular permeability is established by proliferation of perivascular connective tissue. Here the oedema has completely disappeared. A clearcut influx of monocytes from the blood into the vessel wall is seen only in the vicinity of necrotic foci; the number of histiocytes is increased and their turnover is observed in swollen macrophages. In the rest of the tumour influx of monocytes and activity of macrophages are inconspicious.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433277
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