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  • 1
    Electronic Resource
    Electronic Resource
    Rhabdoid tumor of the kidney associated with a tumor of the posterior fossa (1998)
    Springer
    European radiology 8 (1998), S. 259-261 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Rhabdoid tumor ; Kidney ; Brain tumor ; Percutaneous biopsy ; Child
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We report a case of a malignant rhabdoid tumor of the kidney (MRTK) associated with a cerebellar tumor. Diagnosis was confirmed before neoadjuvant chemotherapy by a percutaneous fine-needle biopsy of the abdominal tumor. The clinical and radiologic features of this rare association of childhood neoplasms are reviewed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050374
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  • 2
    Electronic Resource
    Electronic Resource
    IMMUNOMAGNETIC DEPLETION OF MALIGNANT CELLS FROM AUTOLOGOUS BONE MARROW GRAFT: FROM EXPERIMENTAL MODELS TO CLINICAL TRIALS (1989)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 16 (1989), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Using experimental models with normal allogeneic bone marrow (BM) contaminated with Burkitt or neuroblastoma cell lines, and a liquid culture assay, we demonstrated that, when used in optimal conditions, the immunomagnetic depletion technique permitted a reproducible elimination of 3–4 log malignant cells. Results were very similar to those obtained with the complement lysis procedure in Burkitt lymphoma. This immunomagnetic procedure was used in 123 cases of autologous bone marrow transplantation (ABMT) in children with neuroblastoma. The analysis of the cases demonstrated, first, that the procedure induced a significant loss of mononuclear cells but was not toxic for BM precursors. Delays to engraftment observed in a few patients were probably due to the combination of pejorative factors, especially the damage caused to the micro-environment by previous heavy and prolonged chemotherapy or the double ABMT programme. Second, patients presented with profound T-cell defect with undetectable IL2 secretion up to 1 year post-graft but they all had normal NK functions from the first month post-graft, these functions exceeding normal values on the second and third months post-graft. Finally, in 20 cases, dual-immunofluorescence staining permitted the demonstration that the autograft contained malignant cells before purging that were eliminated by the immunomagnetic depletion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1989.tb00454.x
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  • 3
    Electronic Resource
    Electronic Resource
    Cerebral oligodendrogliomas in children: an analysis of 15 cases (1996)
    Springer
    Child's nervous system 12 (1996), S. 527-529 
    Details
    ISSN: 1433-0350
    Keywords: Children ; Oligodendroglioma ; Radiation therapy ; Chemotherapy ; Outcome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The cases of 15 children operated on for cerebral pure oligodendroglioma were studied. Two groups of children were distinguished. Group 1 children presented with epilepsy (7 cases); their tumor was histologically benign in all cases. These children are all alive after a median follow-up of 72 months; however, 2 of them presented with a local recurrence, which was operated on, and are actually disease-free. Group 2 children presented with intracranial hypertension (8 cases); the tumor was anaplastic in 7 cases. Despite postoperative radiotherapy and chemotherapy 6 children died; their median survival time was 17 months. The present series shows the existence of a clear correlation between clinical presentation, histological grading and survival in childhood cerebral oligodendrogliomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00261605
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  • 4
    Electronic Resource
    Electronic Resource
    Spinal cord compression by secondary epi- and intradural metastases in childhood (1997)
    Springer
    Child's nervous system 13 (1997), S. 383-387 
    Details
    ISSN: 1433-0350
    Keywords: Key words Spinal cord compression ; Metastases ; Child ; Solid tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Over a 9-year period, 35 out of 614 children with malignant tumours who were treated at the Centre Léon Bérard developed spinal metastases. Of these, 18 with known malignancies before the development of spinal cord compression are reviewed. The most common tumours causing spinal metastases were Ewing's sarcoma, neuroblastoma and renal tumours. Cord compression occurred 5–88 months after the diagnosis of systemic cancer. The median interval from first symptoms to the diagnosis of compression was 17 days. There were 16 patients with neurological deficit, including 5 with paraplegia. Specific imaging procedures were performed in 16 patients. Treatment included operation in 8 patients, followed by chemotherapy (6 patients) and/or radiotherapy (4 patients); 9 of the 10 non-operated patients received radiotherapy. Only 6 patients had a significant neurological improvement. All patients but 1 died within a median time of 2 months. Early diagnosis might prevent permanent disability in these children with a short survival expectancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810050105
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  • 5
    Electronic Resource
    Electronic Resource
    Chemotherapy for spinal cord astrocytoma: can natural history be modified? (1998)
    Springer
    Child's nervous system 14 (1998), S. 317-321 
    Details
    ISSN: 1433-0350
    Keywords: Key words Spinal cord ; Astrocytoma ; Chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Standard treatment of spinal cord astrocytomas is based upon surgery, followed by radiotherapy when resection is incomplete or when histology is of high grade. Owing to the major consequences of radiotherapy on the spine in childhood, alternative therapies must be explored. The potential role of chemotherapy in the management of spinal cord astrocytoma remains to be defined. Two patients are described. The first was a 19-month-old child with an anaplastic astrocytoma of the cervical spinal cord that progressed rapidly after initial partial resection. Chemotherapy was begun according to the UKCCSG Baby Brain Protocol, with marked clinical improvement. Reassessment by MRI at 4 months showed improvement, and at the end of treatment no evaluable disease remained. The second was a 4-year-old child with a recurrent low-grade astrocytoma. Chemotherapy according to the SIOP Protocol for Low Grade Gliomas was administered for 3 months, after which marked tumour regression was seen, with neurological recovery. These patients demonstrate the potential value and low morbidity of chemotherapy in spinal cord astrocytoma. The management of this rare tumour is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810050233
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  • 6
    Electronic Resource
    Electronic Resource
    Chemotherapy for intracranial ependymomas (1999)
    Springer
    Child's nervous system 15 (1999), S. 563-570 
    Details
    ISSN: 1433-0350
    Keywords: Key words Ependymoma ; Children ; Chemotherapy ; Phase II
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Chemotherapy has been used extensively in the management of children with intracranial ependymoma. In this review, we discuss the results of phase II studies and clinical trials conducted in newly diagnosed and recurrent ependymomas. There is little evidence that chemotherapy is effective in this tumour. The response rate to single agents is 11%, with less than 5% complete responses, cisplatin being the most active agent in phase II studies. Combinations may be more effective, although the response rate with high-dose regimens is disappointing. Early results of protocols conducted in infants and young children do not suggest that chemotherapy is beneficial. A more rigorous assessment of chemotherapy is required in order to define its role in patients with intracranial ependymomas. Indeed, it is difficult to justify the use of chemotherapy outside such studies. More large studies, perhaps intergroup, limited to children with ependymomas would be of particular value.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810050544
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  • 7
    Electronic Resource
    Electronic Resource
    High-dose VP16 cisplatinum in soft tissue sarcoma of children (1994)
    Springer
    Cancer chemotherapy and pharmacology 33 (1994), S. 355-357 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Nine children with soft tissue sarcomas, five of them rhabdomyosarcomas with initial metastatic disease, (one patient, partial response, one patient), refractory primary, (two patients, relapse, five patients) were treated with a combination of high-dose VP16 (100 mg/m2 daily for 5 days) and cisplatin (40 mg/m2 daily for 5 days). The response rate was five out of nine or 55% (±32%) (two complete and three partial, responses). Three of the five responders had rhabdomyosarcomas. The duration of response was 4 – 58 months (median 11 months). The toxicity was mainly hematological. Thus, the high-dose VP16 – cisplatin association warrants further evaluation in soft tissue sarcoma in children.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685912
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  • 8
    Electronic Resource
    Electronic Resource
    High-dose VP 16 cisplatinum in soft tissue sarcoma of children (1994)
    Springer
    Cancer chemotherapy and pharmacology 33 (1994), S. 355-357 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nine children with soft tissue sarcomas, five of them rhabdomyosarcomas with initial metastatic disease, (one patient, partial response, one patient), refractory primary, (two patients, relapse, five patients) were treated with a combination of high-dose VP 16 (100 mg/m2 daily for 5 days) and cisplatin (40 mg/m2 daily for 5 days). The response rate was five out of nine or 55% (±32%) (two complete and three partial, responses). Three of the five responders had rhabdomyosarcomas. The duration of response was 4–58 months (median 11 months). The toxicity was mainly hematological. Thus, the high-dose VP 16-cisplatin association warrants further evaluation in soft tissue sarcoma in children.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685912
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  • 9
    Electronic Resource
    Electronic Resource
    Successfull treatment for a metastatic supratentorial malignant rhabdoid tumor (1993)
    Springer
    Journal of neuro-oncology 17 (1993), S. 65-70 
    Details
    ISSN: 1573-7373
    Keywords: brain ; children ; Rendu-Osier disease ; chromosome 22 ; genetic ; neoplasm ; rhabdoid tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The case of a boy with a familial history of Rendu-Osier disease, who successively developed a cerebellar pilocytic astrocytoma (at 3 years of age) and a metastatic supratentorial malignant rhabdoid tumor (at the age of 12 years) is reported. After a complete surgical removal, the CSF was cleared by 4 courses of chemotherapy, and the child received a craniospinal irradiation. He is currently alive and well 19 months after completion of the treatment. The authors discuss the ethiopathogeny of such intracranial tumors and argue for aggressive treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01054275
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  • 10
    Electronic Resource
    Electronic Resource
    An attempt to treat pediatric intracranial αFP and βHCG secreting germ cell tumors with chemotherapy alone. SFOP experience with 18 cases (1998)
    Springer
    Journal of neuro-oncology 37 (1998), S. 229-239 
    Details
    ISSN: 1573-7373
    Keywords: brain neoplasm ; germ cell tumors ; children ; chemotherapy ; radiotherapy ; markers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: Intracranial αFP and βHCG secreting germ cell tumors have a very poor prognosis with local treatment alone. Because of efficacy of chemotherapy in extracranial forms, we tried in the SFOP (Société Française d'Oncologie Pédiatrique) to treat them with chemotherapeutic treatment exclusively. Patients and methods: Eighteen patients (10 αFP, 2 βHCG, 6 αFP and βHCG secretion) were enrolled from January 1988 to December 1992. After biological diagnosis patients were to receive 6 cycles of chemotherapy (vinblastine – bleomycin – carboplatin or etoposide – carboplatin/ifosfamide – etoposide). After completion of chemotherapy, surgery was to be performed in case of residual tumor. Focal radiation was only to be delivered in case of viable residual tumor. Results: All patients had biological remission and tumor reduction. Fifteen patients were treated according to the protocol by chemotherapy alone (13) or chemotherapy and radiation of residue [2]. Twelve of the 13 non irradiated patients relapsed, 8 in local and/or regional area, 3 in cerebrospinal area and 1 in undeterminated area with mild elevation of markers except in one case. Six patients are alive in second complete remission after chemotherapy and/or surgery and then a consolidation treatment with radiation and/or high dose chemotherapy (5) or craniospinal radiation (1). Three patients received radiation after 2 or 3 cycles of chemotherapy as protocol violations and didn't relapse. Thus, 12 patients out of the 18 patients are alive with a median follow up of 68 months. All but 1 had focal radiation as part of treatment. No toxic death was observed. Conclusion: Although survival rate is noteworthy (66%), these tumors were not curable with this conventional chemotherapy alone and focal radiotherapy should be part of the treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005863601481
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