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  • 1
    Electronic Resource
    Electronic Resource
    Inorganic nitrogen metabolism in marine bacteria: Nitrate uptake and reduction in a marine pseudomonad (1975)
    Springer
    Marine biology 31 (1975), S. 7-13 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Growth experiments in batch cultures indicated that the uptake of nitrate by the marine pseudomonad PL1 was inhibited in the presence of ammonia provided that the ammonia concentration was higher than 1 mM. At ammonia concentrations of less than about 1 mM, however, both nitrate and ammonia were utilised simultaneously. The saturation constants for nitrate and ammonia uptake were both 2.6x10-4 M, and similar to the Michaelis constants of nitrate reductase for nitrate (2.9x10-4 M) and glutamine synthetase for ammonia (2x10-4 M). Nitrate reductase activity linked to NADH was detected in chemostat-grown cultures with nitrate as nitrogen source, and in cultures containing limiting concentrations of nitrate and ammonia, ammonia or glutamate. Enzyme synthesis appeared to be repressed in cultures containing an excess of ammonia or glutamate. Chemostat cultures utilised ammonia or glutamate in preference to nitrate, while there was no marked preference between ammonia and glutamate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390642
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  • 2
    Electronic Resource
    Electronic Resource
    Inorganic nitrogen metabolism in marine bacteria: The intracellular free amino acid pools of a marine pseudomonad (1976)
    Springer
    Marine biology 38 (1976), S. 101-109 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The marine pseudomonad bacterium PL1 contains an intracellular pool of free amino acids which consist mainly of glutamate with small amounts of glutamine and aspartate when grown in a nutrient medium containing 0.2 M NaCl. When the NaCl concentration of the growth medium is increased to 0.8 M, proline becomes a major component of the intracellular pool together with glutamate—at this molarity and under suitable nutrient conditions these amino acids comprise 20% of total bacterial amino acid nitrogen. When grown in a nutrient growth medium containing a constant level of NaCl, the intracellular pool size can vary by a factor of 4 depending on the concentration of carbon and nitrogen in the medium. Experiments show that the amino acid pool can act as a nitrogen reserve but has little function as a carbon reserve. At high NaCl concentrations there is a marked dependence for growth on the presence of sufficient potassium in the medium. However, no correlation between K+ and glutamate concentration in either nitrogen or K+-limited cultures has been found. None of the enzymes associated with glutamate biosynthesis was influenced by NaCl levels between 0.2 and 0.5 M. Neither Na+ or K+ stimulated the activity of these enzymes when tested in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390763
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  • 3
    Electronic Resource
    Electronic Resource
    Some biologically important low molecular weight organic acids in the sediments of Loch Eil (1979)
    Springer
    Marine biology 50 (1979), S. 375-383 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The isolation of biologically important low molecular weight organic acids from organically enriched sediments in Loch Eil, Scotland, was carried out by extraction of pore water with acidified ethyl acetate. High concentrations of acetic acid, up to 1.8 mg g-1 dry weight of sediment were found at Station E-24. Propionate, butyrate, valerate, lactate and traces of succinate were also found. Succinate was present in significant amounts, 42.2 μg g-1 dry weight of sediment at Station E-70, which received a higher input of organic matter than E-24. Both propionate and succinate were absent from a control station in the Lynn of Lorne where the sediment was low in carbon compared with Loch Eil. In experimental tanks, acetate levels increased as the input of organic carbon (as cellulose) was increased up to a load level of 1.5 g m-2 day-1. Above this, acetate decreased and succinate appeared. Succinate was not detected in low-loaded tanks. Experiments with sieved mud showed a vertical distribution of the different acids with depth. Lactate and succinate reached highest concentration in the 0 to 3 cm layer, acetate at 3 to 6 cm and propionate at 6 to 9 cm. The results are discussed in relation to the role of these acids as food sources and as indicators of biochemical pathways taking place in sediments with different carbon input levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00387015
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  • 4
    Electronic Resource
    Electronic Resource
    On the kinetic depth effect (1989)
    Springer
    Biological cybernetics 60 (1989), S. 445-455 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract The problem of the kinetic depth effect is revisited. We study how many points in how many views are necessary and sufficient to recover structure. The constraints in the cases where the velocities of the image points are known, and the positions of the image points are known with the correspondence between them established, are different and they have to be studied separately. In the case of two projections of any number of points there are infinitely many solutions, but if we regularize the problem we get a unique solution under some assumptions. Finally, an algorithm is discussed for learning this particular kind of regularization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00204700
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  • 5
    Electronic Resource
    Electronic Resource
    Ammonia assimilation in the fission yeast Schizosaccharomyces pombe 972 (1977)
    Springer
    Archives of microbiology 111 (1977), S. 265-270 
    Details
    ISSN: 1432-072X
    Keywords: Ammonia assimilation ; Glutamine synthetase ; Continuous culture ; Regulation ; Inactivation ; New synthesis ; Schizosaccharomyces pombe
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Glutamine synthetase (GS) activity of Schizosaccharomyces pombe 972 was high in ammonia-limited cultures, low in phosphate-and sulphate-limited cultures and not detected in glucose-limited cultures. When ammonia was ‘pulsed’ into an ammonia-limited culture then GS activity decreased at a rate faster than that calculated if enzyme synthesis ceased and enzyme was diluted out by growth. Enzyme activity increased in ammonia-starved, phosphate-limited cultures and in the ammonia ‘pulse’ system when the added ammonia had been utilised. These increases in enzyme activity were prevented by the presence of 100 μg/ml cycloheximide. GS activity was inversely related to the intracellular concentration of glutamate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00549365
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  • 6
    Electronic Resource
    Electronic Resource
    CD5+B in Rheumatoid Arthritis (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 651 (1992), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1992.tb24660.x
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  • 7
    Electronic Resource
    Electronic Resource
    XUV spectral observations with two-wavelength laser irradiation (1988)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 59 (1988), S. 1837-1839 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: XUV diagnostic equipment was designed and utilized on the OMEGA target chamber at the University of Rochester to study high atomic number plasma generation by two-wavelength laser excitation. Spectral data were collected from silver tracer dot targets irradiated with 1/3 TW of 0.35-μm laser light of the multiple-beam OMEGA laser and the single synchronized 1.06-μm beam of the GDL laser for generating energetic electrons. XUV spectral data in the 30–300-A(ring) region were obtained with both a 3-m grazing incidence spectrograph and a compact 1-m grazing incidence spectrograph designed for reentrant mounting in the OMEGA chamber. High-resolution x-ray spectra were acquired in the 3.6–4.2-A(ring) region with a dual, flat-diffraction crystal spectrograph. A low-resolution x-ray spectrum of silver was recorded with a curved mica spectrograph. Some x-ray spectral lines appeared only when both OMEGA and GDL beams were used. These were identified as 2p–3s,3d transitions in F-like Ag xxxix. F-, Na-, and Mg-like lines were found in the grazing incidence spectra, with F-like lines appearing only with 1.06-μm irradiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1140076
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  • 8
    Electronic Resource
    Electronic Resource
    The pathology of acute hepatic disintegration in hereditary haemorrhagic telangiectasia (2003)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 42 (2003), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims:  Hereditary haemorrhagic telangiectasia is a rare inherited disease in which telangiectases affect skin, mucous membranes and the gastrointestinal tract. Hepatic involvement is common but usually asymptomatic. We report a case of acute hepatic disintegration in hereditary haemorrhagic telangiectasia, document the histopathological findings and present a hypothesis to explain them.Methods and results:  The patient presented at the age of 34 years with abdominal pain, leading to the surgical removal of a severely inflamed gallbladder. Signs of liver damage became increasingly apparent over the next few weeks, with disruption of the intrahepatic biliary tree and marked vascular shunting, necessitating liver transplantation. Six months after the transplant a diagnosis of hepatic hereditary haemorrhagic telangiectasia was made. The principal features of hepatic hereditary haemorrhagic telangiectasia are periportal telangiectases and sinusoidal congestion and dilatation. Acute hepatic disintegration is characterized by disruption of liver structure, hepatocyte necrosis, haemorrhage and extravasation of bile.Conclusions:  Periportal telangiectases in a liver biopsy are highly suggestive of hereditary haemorrhagic telangiectasia. Acute hepatic disintegration is likely to be a consequence of rupture of telangiectases and ischaemic necrosis of intrahepatic bile ducts. Patients with hereditary haemorrhagic telangiectasia are at risk of acute hepatic disintegration following intra-abdominal sepsis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.2003.01579.x
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  • 9
    Electronic Resource
    Electronic Resource
    Lifarizine: A Blocker of Inactivated Voltage-dependent Sodium Channels and Calcium Channels with Cerebral Neuroprotective Action (1995)
    Oxford, UK : Blackwell Publishing Ltd
    CNS drug reviews 1 (1995), S. 0 
    Details
    ISSN: 1527-3458
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1527-3458.1995.tb00281.x
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  • 10
    Electronic Resource
    Electronic Resource
    Imaging of laser-irradiated targets at a wavelength of 33.8 A(ring) using a normal-incidence multilayer mirror (1994)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 1 (1994), S. 1997-2002 
    Details
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The morphology of the 33.8 A(ring) emission from laser-irradiated targets was studied using a concave mirror with a W/B4C multilayer coating. The mirror had peak normal-incidence reflectance of 1.8% at a wavelength of 33.8 A(ring). The emissions from a variety of targets were imaged on film with a spatial resolution of 30 μm in the target plane. Radiatively heated, low-density plastic and silica foams, x-ray laser targets, and a gas-filled enclosure were imaged. Several targets were simultaneously imaged at wavelengths of 33.8 and 130 A(ring) using two normal-incidence microscopes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.870655
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