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  • 1
    Digitale Medien
    Digitale Medien
    Maternal and cord plasma concentrations of β-lipotrophin, β-endorphin and γ-lipotrophin at delivery; effect of analgesia (1983)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 90 (1983), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary. Maternal venous plasma concentrations of β-LPH, β-EP and γ-LPH were compared in (i) patients undergoing vaginal delivery, 11 with an epidural block and 13 with pethidine and nitrous oxide or no analgesics; (ii) patients delivered by caesarean section, 7 under epidural block and 8 under general anaesthesia. Patients delivered by either method under epidural block had significantly lower levels of all three peptides than those receiving no epidural. There were significant negative correlations between umbilical vein β-LPH, β-EP and γ-LPH concentrations and umbilical artery pH and positive correlations between β-LPH and β-EP but not γ-LPH and cord PCO2 in 29 patients. There was no relation between cord levels of any of the three peptides and the method of analgesia or the route of delivery. Although concentrations of all three peptides were closely correlated to one another in either maternal or cord plasma, there was no relationship between maternal and fetal levels.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1983.tb06463.x
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  • 2
    Digitale Medien
    Digitale Medien
    Maternal plasma concentrations of β-lipotrophin, β-endorphin and γ-lipotrophin throughout pregnancy (1983)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 90 (1983), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary. Plasma β-LPH, β-EP and γ-LPH concentrations were measured by radioimmunoassay in 10 pregnant women from 12 weeks gestation until term and in nine women in the early follicular phase of the cycle. There was a progressive and significant rise in the concentration of all three peptides throughout pregnancy and by 32 weeks the concentrations of β-LPH and β-EP were greater than the corresponding concentrations in the follicular phase: γ-LPH was greater than in the follicular phase by the end of pregnancy in those women who were delivered after 40 weeks. The ratio of β-LPH to γ-LPH did not change significantly throughout pregnancy, but there was a progressive fall in the β-LPH/β-EP ratio. The possible presence of a ‘big LPH’ to explain this finding is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1983.tb06462.x
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  • 3
    Digitale Medien
    Digitale Medien
    SEX HORMONE LEVELS AND GONADOTROPHIN RELEASE IN PREMATURE OVARIAN FAILURE (1978)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 85 (1978), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Premature ovarian failure was studied in ten women under the age of 30; eight had an ovarian biopsy and five of these showed primordial follicles. Plasma levels of oestradiol and progesterone were similar to the follicular phase of a normal menetrual cycle, but in eight patients cervical smears showed a cornification index of less than one per cent. Levels of both androgens and of sex hormone binding globulin capacity were generally normal. Administration of LH-RH caused a release of FSH which was similar to post menopausal women and higher than normally menstruating women, and a release of LH which was higher than both. Two patients were treated with exogenous gonadotrophins without effect.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1978.tb15844.x
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  • 4
    Digitale Medien
    Digitale Medien
    ENDOCRINE STUDIES IN POST-MENOPAUSAL WOMEN WITH OVARIAN TUMOURS (1971)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 78 (1971), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: An endocrine assessment was made in 78 post-menopausal women.The urinary excretion of oestriol was greater than 10 μg. per 24 hours in 14 out of 31 cases with malignant ovarian tumours, in 2 out of 24 cases with benign ovarian tumours, and in 6 out of 23 cases without ovarian tumours. Although the urinary oestriol excretion was increased in all 8 cases with mucinous carcinoma it was raised in only 4 out of 18 cases with serous carcinoma. Some of the greatest amounts of urinary oestriol were found in cases without ovarian tumours.The urinary excretion of pregnanediol was increased in 6 out of 18 cases. These six patients also had increased oestriol excretion.The excretion of steroids was normal after oöphorectomy.Tests of adrenal cortical activity and ovarian vein blood analysis also point to the diseased ovary as the site of increased steroid synthesis.The correlation of increased urinary oestriol with vaginal cornification index was fair, but with vaginal bleeding and endometrial activity was poor.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1971.tb00303.x
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  • 5
    Digitale Medien
    Digitale Medien
    THE RELATIONSHIP OF TOTAL AND DIFFERENTIAL LEUKOCYTE COUNTS WITH URINARY OESTROGEN AND PLASMA CORTISOL LEVELS (1970)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 77 (1970), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: In a group of 20 women undergoing a course of human pituitary gonadotrophic hormone injections a significant positive correlation (P〈0.001) between urinary total oestrogens and the total leukocyte, neutrophil and monocyte counts in blood was demonstrated. The relationship was independent of changes in progesterone secretion, plasma cortisol levels and the initial value of the total leukocyte count. In some individuals, differences up to 6000 cells per c.mm. exist between neutrophil counts associated with the lowest and the highest oestrogen levels.A significant negative correlation (P〈0.001) between plasma cortisol and the lymphocyte count was found. No relationship between plasma cortisol and urinary total oestrogens, total leukocyte, neutrophil and monocyte counts was seen,In two women who became pregnant during the course of treatment, neutrophil count changes appeared to be a continuation of events that were happening before conception, indicating that neutrophilia of pregnancy is related to alterations in oestrogen production, separate from progesterone and plasma cortisol fluctuations. The possible role of oestrogens in association with the postmenopausal decrease and the normal ovulatory peak in neutrophil count was discussed. Their place in the scheme of general body defence against infection and their possible associations with obscure neutropenias in women were also considered.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1970.tb03583.x
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  • 6
    Digitale Medien
    Digitale Medien
    Review of 59 patients with hypergonadotrophic amenorrhoea (1984)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 91 (1984), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary. Fifty-nine patients presented with elevated concentrations of gonadotrophins and secondary amenorrhoea before the age of 35 years. Fifty-three underwent laparoscopic examination and primordial follicles were observed in 16. Two others had follicles as they later became pregnant and a third showed biochemical evidence of spontaneous ovulation. There were streak ovaries in 12, two with follicles and three others with chromosomal abnormalities, two being 47XXX and one XO/XX. Two other patients had only one ovary each but no follicles. Chromosomal abnormalities were detected in two further patients one being XO/XX and the other a recombinant. Six patients became pregnant, two of them twice, resulting in four term deliveries and four spontaneous abortions. Three other patients showed biochemical evidence of ovulation; one spontaneously, one after oestrogen therapy and the third after treatment with gonadotrophin releasing hormone analogue.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1984.tb05280.x
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  • 7
    Digitale Medien
    Digitale Medien
    OESTROGEN-GONADOTROPHIN FEEDBACK ABNORMALITIES IN HYPERPROLACTINAEMIC AMENORRHOEA DEMONSTRATED BY THE RESPONSE TO CLOMIPHENE ADMINISTRATION (1979)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 86 (1979), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Clomiphene was administered to 16 patients with elevated serum prolactin levels in doses of 100, 200 and 300 mg/day for five days in succeeding months and total urinary oestrogens estimated on days 0, 5, 8, 12 and 15 following commencement of treatment. The responses were compared with six patients who were amenorrhoeic but had normal serum prolactin levels and absent positive feedback to oestrogen. The increased outputs of oestrogens were similar in the two groups. In the hyper- prolactinaemic group 5 out of 16 subjects showed evidence of ovulation whilst the remainder showed a secondary failure of response. Six subjects who failed to ovulate were treated with clomiphene and human chorionic gonadotrophin (HCG) and ovulations were induced in 31 out of 34 treatment cycles but no pregnancies were achieved. The responses to clomiphene therapy in the hyperprolactinaemic subjects were compared to the assessment of positive feedback mechanisms by means of oestrogen provocation and oestrogen amplification tests and good correlation was obtained. Only those with evidence of positive feedback to these tests were likely to ovulate on clomiphene.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1979.tb10686.x
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  • 8
    Digitale Medien
    Digitale Medien
    INTER-RELATIONSHIPS BETWEEN LEVELS OF PLASMA OESTRADIOL, URINARY TOTAL OESTROGENS AND BLOOD HAEMOGLOBIN AND NEUTROPHIL COUNTS (1972)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 79 (1972), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The inter-relationships between levels of urinary total oestrogens, plasma oestradiol and blood haemoglobin and neutrophil levels were investigated in five women undergoing treatment with pituitary gonadotrophin hormone for infertility. Predicted values for urinary oestrogens were also calculated from the haemoglobin and neutrophil results.There was a positive correlation of plasma oestradiol with both actual and predicted concentrations of urinary oestrogens but there was substantial variation between patients. The levels of plasma and urinary oestrogens showed a significant positive correlation with the blood neutrophil counts, a negative but not significant correlation with the haemoglobin concentration, and a highly significant correlation with the ratio of the two observations. Again marked variation between subjects occurred.The use of these parameters for monitoring the treatment of infertile patients with human gonadotrophins is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1972.tb14183.x
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  • 9
    Digitale Medien
    Digitale Medien
    A clinical trial using danazol for the treatment of premenstrual tension (1987)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 94 (1987), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary. Forty women with premenstrual tension received either placebo, 100, 200 or 400 mg danazol daily for 3 months in a pilot study arranged as a double-blind trial. Thirteen patients withdrew by the third month usually because they complained of no improvement. They had significantly higher pretrial symptom scores than those who continued. In patients treated with danazol, symptom scores for breast pain during the second and third months and for irritability, anxiety and lethargy during the third month were significantly (P〈0.05) lower than scores in those given placebo. Most symptoms improved on placebo in the first month but by the third month only three remained improved. In contrast eight symptoms were improved on 200 mg danazol by the third month. By the end of the trial more than 75% of patients who were still taking danazol were essentially free of breast pain, lethargy, anxiety and increased appetite, but results for other common symptoms were no better than with placebo.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1987.tb02248.x
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  • 10
    Digitale Medien
    Digitale Medien
    Hormonal studies in women with premenstrual tension (1985)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 92 (1985), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary. Serum hormone concentrations were determined at intervals during the last 17 days of the menstrual cycle in 35 patients with premenstrual tension (PMT) and 11 control subjects without symptoms. The maximum mean concentration of oestradiol occurred 17 days before menstruation in the patients and 14 days before in the controls. The maximum concentrations of progesterone were similar in the two groups but the mean concentrations rose carlier in the cycle in the patients with PMT. These results suggested that the patients tended to ovulate earlier in the cycle than the controls and on the basis of the ovulatory surge in gonadotrophins two groups could be identified, group A who showed signs of ovulation 14 days or less before menstruation (17 patients, 9 controls) and group B who ovulated more than 14 days before menstruation (18 patients, 2 controls). There were no significant differences between the groups in prolactin, thyroid stimulating hormone or testosterone levels, but cortisol concentrations were uniformly higher in both groups of patients compared with those in the controls. Follicular growth was assessed with ultrasound in 18 patients and 16 control subjects. Mean follicular diameters were significantly lower in the patients than in the control group at the time of ovulation. Oestradiol determinations done at the same time correlated with the diameters and were also significantly lower in the patient group. The results suggest that ovulation tends to occur prematurely in women with PMT.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1985.tb01090.x
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