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  • 1
    Electronic Resource
    Electronic Resource
    Trans-[(en)2Co(Cl)(S2O3)], Na[trans-[(en)2Co(C2O4)(S2O3)]], trans-[(en)2Co(NCO)(S2O3)], and the nature of [(en)2Co(OH2)(S2O3)]+ in aqueous solution (1983)
    s.l. : American Chemical Society
    Inorganic chemistry 22 (1983), S. 3060-3065 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00163a017
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  • 2
    Electronic Resource
    Electronic Resource
    Ovarian Steroid Regulation of Estrogen and Progesterone Receptor Messenger Ribonucleic Acid in the Anteroventral Periventricular Nucleus of the Rat (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neuroendocrinology 8 (1996), S. 0 
    Details
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The anteroventral periventricular nucleus of the preoptic region (AVPV) represents a key site for hormonal feedback on gonadotropin secretion. It plays a critical role in the neural control of luteinizing hormone secretion and contains high densities of neurons that express receptors for estrogen and progesterone. In this study in situ hybridization was used to examine the expression of mRNAs encoding the estrogen (ER) and progesterone (PR) receptors in the AVPV during the estrous cycle. ER gene expression fluctuated during the cycle with the lowest levels of ER mRNA observed in animals killed on the afternoon of proestrus, and the highest levels present in animals killed during metestrus. This apparent inverse relationship between circulating levels of estradiol (E2) and ER mRNA levels in AVPV neurons was supported by the observation that treatment of ovariectomized rats with E2 suppressed expression of ER mRNA in the AVPV. The influence of progesterone (P4) on ER expression was less pronounced, but a significant increase in ER mRNA in the AVPV was detected 3 h after treatment with P4. In contrast, PR mRNA levels were highest in the AVPV during diestrus and lowest on the morning of proestrus suggesting that PR expression in the AVPV is regulated in a complex manner that may reflect the combined regulatory effects of E2 and P4. E2 treatment caused a dramatic induction of PR mRNA in the AVPV, but P4 did not affect PR mRNA expression acutely, although PR mRNA appears to be attenuated in the AVPV 27 h after P4 treatment. These findings suggest that ovarian steroid hormones regulate ER and PR gene expression in the AVPV during the estrous cycle, which may represent molecular events that contribute to cyclic changes in the responsiveness of AVPV neurons to steroid hormones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2826.1996.tb00685.x
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  • 3
    Electronic Resource
    Electronic Resource
    Molecular analysis of hus1 +, a fission yeast gene required for S-M and DNA damage checkpoints (1997)
    Springer
    Molecular genetics and genomics 254 (1997), S. 389-399 
    Details
    ISSN: 1617-4623
    Keywords: Key words Fission yeast ; Checkpoint ; Cell cycle ; Hus1
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The structure of hus1 +, a Schizosaccharomyces pombe gene required for S-M and DNA damage checkpoints, has been determined. Expression of hus1 + requires splicing of five exons, including a microexon that is only 13 nucleotides long. hus1 + is predicted to encode a 33 kDa protein with no similarity to sequences in any database, including the entire S. cerevisiae genome. Yeast strains disrupted for the hus1 + gene are viable but checkpoint-defective. Polyclonal antibodies were raised against bacterially expressed Hus1 protein, and used to study Hus1 regulation. Hus1 protein levels are not affected by S-phase arrest, and are not altered by mutations in other checkpoint genes, suggesting that Hus1 is not regulated at the transcriptional or translational levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00008606
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  • 4
    Electronic Resource
    Electronic Resource
    Characterisation of the Schizosaccharomyces pombe rad4/cut5 mutant phenotypes: dissection of DNA replication and G2 checkpoint control function (1997)
    Springer
    Molecular genetics and genomics 255 (1997), S. 332-340 
    Details
    ISSN: 1617-4623
    Keywords: Key wordsSchizosaccharomyces pombe ; Checkpoint control ; γ-Irradiation ; DNA replication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Mutation of the essential Schizosaccharomyces pombe rad4/cut5 gene causes sensitivity to UV and ionising radiation at the permissive temperature whilst at the restrictive temperature cells fail to undergo DNA replication but still attempt mitosis owing to a defective S-phase checkpoint response. Many mutations in genes encoding DNA replication proteins also abolish checkpoint responses, possibly because the replication machinery is a pre-requisite for the generation of the signal. We demonstrate here that rad4/cut5 cells fail to arrest cell division when treated with the replication inhibitor hydroxyurea at the semi-permissive temperature 32° C, but retain essentially normal replicative capacity. This demonstrates that the replication and checkpoint function of the rad4/cut5 gene product can be separated and that the Rad4 protein differs from other replication proteins in being directly involved in generating the S-phase checkpoint signal. Furthermore, we have investigated the checkpoint response or rad4/cut5-deficient cells to γ-irradiation and UV-mimetic drugs. We find that, at the restrictive temperature, the rad4 − /cut5 − cells fail to delay mitosis in response to γ-irradiation whilst retaining a normal checkpoint response to the UV-mimetic drug 4-nitroquinoline-1-oxide. The lack of the γ-irradiation checkpoint is reminiscent of the deficiency associated with mutation of the human ATM locus, the causative deficiency of the heritable disorder ataxia telangiectasia. The implications of our results for the organisation of distinct checkpoint-response pathways in both fission yeast and mammalian cells are discussed. Moreover the data are consistent with a model in which the generation of the S-Phase checkpoint signal is DNA polymerase ɛ dependent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380050504
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  • 5
    Electronic Resource
    Electronic Resource
    Cloning of caf1 +, caf2  + and caf4  + from Schizosaccharomyces pombe : their involvement in multidrug resistance, UV and pH sensitivity (1998)
    Springer
    Molecular genetics and genomics 260 (1998), S. 434-443 
    Details
    ISSN: 1617-4623
    Keywords: Key words Schizosaccharomyces pombe ; Caffeine resistance ; Brefeldin A resistance ; Multidrug resistance ; Cell cycle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We previously identified four nuclear genes (caf1 + to caf4 +) in Schizosaccharomyces pombe, mutations in which can confer caffeine resistance. Here we report the cloning and sequencing of caf1 +, caf2 + and caf4 +. All three genes are allelic to genes (hba1 + , crm1 + and trr1 + , respectively) involved in multidrug resistance mechanisms or in stress response systems. In agreement with this the caffeine-resistant mutants caf1(hba1)-21, caf2(crm1)-3 and caf4(trr1)-83 are also resistant to brefeldin. Disruption of caf1(hba1) + and caf4(trr1) + makes cells sensitive to high pH. The overlapping ranges of pleiotropic effects and the genetic interaction detected between caf1(hba1) + and caf2(crm1) + suggest that the three genes function in interlinked systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380050914
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  • 6
    Electronic Resource
    Electronic Resource
    Cell cycle regulation in yeasts and man: Towards a unifying mechanism (1987)
    Springer
    Antonie van Leeuwenhoek 53 (1987), S. 319-323 
    Details
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400555
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Molecular cloning and sequence analysis of mutant alleles of the fission yeast cdc2 protein kinase gene: Implications for cdc2 + protein structure and function (1989)
    Springer
    Molecular genetics and genomics 218 (1989), S. 41-49 
    Details
    ISSN: 1617-4623
    Keywords: Protein kinases ; cdc2 ; Schizosaccharomyces pombe ; Cell cycle ; Mitotic control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The cdc2 + gene function plays a central role in the control of the mitotic cell cycle of the fission yeast Schizosaccharomyces pombe. Recessive temperature-sensitive mutations in the cdc2 gene cause cell cycle arrest when shifted to the restrictive temperature, while a second class of mutations within the cdc2 gene causes a premature advancement into mitosis. Previously the cdc2 + gene has been cloned and has been shown to encode a 34 kDa phosphoprotein with in vitro protein kinase activity. Here we describe the cloning of 11 mutant alleles of the cdc2 gene using two simple methods, one of which is presented here for the first time. We have sequenced these alleles and find a variety of single amino acid substitutions mapping throughtout the cdc2 protein. Analysis of these mutations has identified a number of regions within the cdc2 protein that are important for cdc2 + activity and regulation. These include regions which may be involved in the interaction of the cdc2 + gene product with the proteins encoded by the wee1 +, cdc13 + and suc1 + genes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00330563
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  • 8
    Electronic Resource
    Electronic Resource
    Analysis of a histone H2A variant from fission yeast: evidence for a role in chromosome stability (1994)
    Springer
    Molecular genetics and genomics 245 (1994), S. 628-635 
    Details
    ISSN: 1617-4623
    Keywords: Schizosaccharomyces pombe ; Histone H2A variant ; Chromosome stability ; H2A.F/Z
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We have isolated and characterised the pht1 gene from the fission yeast Schizosaccharomyces pombe. The sequence of the predicted translation product has revealed a striking similarity to the family of H2A.F/Z histone variant proteins, which have been found in a variety of different organisms. Cells deleted for the pht1 gene locus grow slowly, exhibit an altered colony morphology, increased resistance to heat shock and show a significant decrease in the fidelity of segregation of an S. pombe minichromosome. We propose that the histone H2A variant encoded by the pht1 gene is important for chromosomal structure and function, possibly including a role in controlling the fidelity of chromosomal segregation during mitosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00282226
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