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  • 1
    Electronic Resource
    Electronic Resource
    Étude ultrastructurale de quatre cas de leuco-encéphalite sclérosante subaiguë (1969)
    Springer
    Acta neuropathologica 14 (1969), S. 1-13 
    Details
    ISSN: 1432-0533
    Keywords: Subacute Sclerosing Leucoencephalitis ; Electron Microscopy ; Tubular Inclusions ; Inclusion Bodies (Cristalline Rods, Fibrillar Bundles, Nuclear Bodies, Osmiophilic Particles)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs rapportent 4 observations caractéristiques de LESS: L'analyse ultra-structurale montre: 10 — des inclusions tubulaires intra-nucléaires neuronales ou gliales et intra-axonales de morphologie superposable à celle des nucléocapsides des myxo-virus, de la rougeole en particulier. 20 — des formations non spécifiques: corps nucléaires, faisceaux cristallins et fibrillaires traduisant un trouble métabolique nucléaire, particules osmiophiles liées à une hyperactivité cellulaire. Les inclusions tubulaires virales sont présentes quelque soit la durée de la maladie (3 mois à 5 ans) indiquant l'absence d'autostérilisation virale dans le S.N.C. La LESS apparaît liée au virus rougeoleux mais le mécanisme indirect immunitaire ou métabolique de cette action est inconnu.
    Notes: Summary Four cases of S.S.L.E are reported. The electron microscopy findings show: 1. Tubulary inclusion bodies: They appear in three cases out of four, either in neuronal and glial nucleus or in axis cylinders. Their morphological features are similar to the nucleocapsides of myxoviruses and particularly measles-virus. 2. Other different types of nonspecific inclusions: nuclear bodies, cristalline-like rods and fibrillar bundles which may be considered as the result of a nuclear metabolic disorder, osmiophilic particles which may be seen as the result of a cellular intracytoplasmic hyperactivity. The tubules are found whatever the duration of the disease (3 months up to 5 years) may be. This might indicate that there is no autosterilization of the virus in the C.N.S. during the course of S.S.L.E. According to the most recent papers, such a disease might be interpreted as an infection indirectly induced by measles-virus with an unknown immunologic or metabolic mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687698
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  • 2
    Electronic Resource
    Electronic Resource
    Hypopigmented Macules of Sun Exposed Skin in Xeroderma Pigmentosum. An Electron Microscopic Study (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 2 (1975), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Patients with Xeroderma Pigmentosum (XP) frequently exhibit small, white hypopigmented spots on the parts of the body not exposed to the sun. These hypopigmented spots, 1–5 mm in diameter, appear early in the life. Punch biopsies were performed for electron microscopic studies and DOPA reaction. Melanocytes were either absent or occasionally found along the basal layer of the hypopigmented area; Langerhans cells were numerous; DOPA positive cells were rare or absent. Thus a vitiligo-like syndrome is realized. In clinically normal skin, Langerhans cells were observed within the basal layer. These findings may help explain the clinical appearance of the white macules and the fact that the absence of pigment protection on sun exposed areas exposes the skin widely to UV radiation. It seems logical to propose that apart from the genetic enzymatic defect of XP, there is a genetic melanocytic abnormality leading to conditions which increase the general sensitivity to UV radiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1975.tb00835.x
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  • 3
    Electronic Resource
    Electronic Resource
    Diagnostic and neural analysis of skin cancer (DANAOS). A multicentre study for collection and computer-aided analysis of data from pigmented skin lesions using digital dermoscopy (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 149 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Early detection of melanomas by means of diverse screening campaigns is an important step towards a reduction in mortality. Computer-aided analysis of digital images obtained by dermoscopy has been reported to be an accurate, practical and time-saving tool for the evaluation of pigmented skin lesions (PSLs). A prototype for the computer-aided diagnosis of PSLs using artificial neural networks (NNs) has recently been developed: diagnostic and neural analysis of skin cancer (DANAOS).Objectives  To demonstrate the accuracy of PSL diagnosis by the DANAOS expert system, a multicentre study on a diverse multinational population was conducted.Methods  A calibrated camera system was developed and used to collect images of PSLs in a multicentre study in 13 dermatology centres in nine European countries. The dataset was used to train an NN expert system for the computer-aided diagnosis of melanoma. We analysed different aspects of the data collection and its influence on the performance of the expert system. The NN expert system was trained with a dataset of 2218 dermoscopic images of PSLs.Results  The resulting expert system showed a performance similar to that of dermatologists as published in the literature. The performance depended on the size and quality of the database and its selection.Conclusions  The need for a large database, the usefulness of multicentre data collection, as well as the benefit of a representative collection of cases from clinical practice, were demonstrated in this trial. Images that were difficult to classify using the NN expert system were not identical to those found difficult to classify by clinicians. We suggest therefore that the combination of clinician and computer may potentially increase the accuracy of PSL diagnosis. This may result in improved detection of melanoma and a reduction in unnecessary excisions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2003.05547.x
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  • 4
    Electronic Resource
    Electronic Resource
    Should subjects who used psoralen suntan activators be screened for melanoma? (1997)
    Springer
    Annals of oncology 8 (1997), S. 435-437 
    Details
    ISSN: 1569-8041
    Keywords: attributable risk ; early detection ; melanoma ; psoralens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Psoralens are potent tanning activators that have beenintroduced in France and in Belgium in some tanning lotions and sunscreens.It was shown that poor tanners who ever used psoralen tanning activatorsdisplay a four-fold increase in melanoma risk when compared to poor tannersusing regular sunscreens. Although psoralens have now been banned from suntanlotions, it is likely that the increase in melanoma risk linked to theirprevious use will persist for several years. Methods: The melanoma risk attributable to psoralens use was calculated toevaluate the population at risk in France and Belgium. Results: Melanoma incidence for the year 1995 was estimated to be of 10.2per 100,000 in France and of 10.0 per 100,000 in Belgium, representing 5,900and 1,000 melanoma cases. From the melanoma incidence among poor tanner whoever used psoralens (52 per 100,000) and and estimation of the percentage ofpsoralen users among poor tanners, it can be derived that, for the year 1995,267 melanoma cases could be attributed to psoralen tanning activators. Conclusions: Subjects who used psoralen suntan activators should beinformed of their increased melanoma risk and be encouraged to participate inclinical programmes for early detection of melanoma, more especially when theyare poor tanners and display a high naevi count. Such an action could save asignificant number of lives.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008205513771
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    Paper (German National Licenses)
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