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  • 1
    Electronic Resource
    Electronic Resource
    Ethanol-Induced Cell Death by Lipid Peroxidation in PC12 Cells (1997)
    Springer
    Neurochemical research 22 (1997), S. 1187-1192 
    Details
    ISSN: 1573-6903
    Keywords: Lipid Peroxidation ; ethanol ; Cis-Parinaric acid = fluorescent probe for lipid peroxidation ; Resveratrol = antioxidant from grapes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Free radical generation is hypothesized to be the cause of alcohol-induced tissue injury. Using fluorescent cis-parinaric acid and TBARS, lipid peroxidation was shown to be increased in the presence of trace amounts of free ferrous ion in PC12 cells. This increase in lipid peroxidation was enhanced by ethanol in a dose dependent manner and also correlated with loss of cell viability, as measured by increased release of lactate dehydrogenase (LDH). Resveratrol, a potent antioxidant, had a protective effect against lipid peroxidation and cell death. These findings strongly suggest that ethanol-induced tissue injury and cell death is a free radical mediated process, and may be important in alcohol-related premature aging and other degenerative diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1021968526696
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Oxidative stress and neurodegenerative disorders (1998)
    Springer
    Journal of biomedical science 5 (1998), S. 401-414 
    Details
    ISSN: 1423-0127
    Keywords: Oxidative stress ; Reactive oxygen species ; Excitotoxicity ; Hydroxyl radical ; Peroxynitrite ; Antioxidants ; Polyphenols ; Neurodegenerative disorders ; Apoptosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Oxidative insults, whether over-excitation, excessive release of glutamate or ATP caused by stroke, ischemia or inflammation, exposure to ionizing radiation, heavy-metal ions or oxidized lipoproteins may initiate various signaling cascades leading to apoptotic cell death and neurodegenerative disorders. Among the various reactive oxygen species (ROS) generated in the living organism, hydroxyl and peroxynitrite are the most potent and can damage proteins, lipids and nucleic acids. It appears that some natural antioxidants (tocopherol, ascorbic acid and glutathione) and defense enzyme systems (superoxide dismutase, catalase and glutathione peroxidase) may provide some protection against oxidative damage. Recent findings indicate several polyphenols and antioxidant drugs (probucol, seligilline) are effective in protecting the cells from ROS attack. Further development of these antioxidant molecules may be of value in preventing the development of neurodegenerative diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02255928
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Cp*MCpMoFe(CO)7(μ3-S), Cp*MoCpMFe(CO)7(μ3-S) (M = W, Mo) and Cp*WCp*MoFe(CO)7(μ3-S). Crystal structure of CpMoCp*WFe(CO)7(μ3-S) (2000)
    Springer
    Transition metal chemistry 25 (2000), S. 108-111 
    Details
    ISSN: 1572-901X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract CpMoFeCo(CO)7(μ3-S) reacts with Cp*M(CO)3Cl or CpM(CO)3Cl (M = W, Mo) to gave the mixed-metal clusters Cp*WCpMoFe(CO)7(μ3-S) (1), Cp*MoCpMoFe(CO)7(μ3-S) (2), CpWCp*MoFe(CO)7(μ3-S) (3), CpMoCp*MoFe(CO)7(μ3-S) (4) and Cp*WCp*MoFe(CO)7(μ3-S) (5). The title clusters have been characterized by i.r., 1H/13C-n.m.r. spectroscopy and their compositions have been confirmed by elemental analyses. The X-ray crystal structure analysis shows the two independent enantiomeric molecules of clusters (1) in one crystal structure unit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007072901162
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    Paper (German National Licenses)
    Fulltext
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