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  • 1
    Electronic Resource
    Electronic Resource
    Treatment of cutaneous T-cell lymphoma with a new aromatic retinoid (Ro 10-9359) (1982)
    Springer
    Archives of dermatological research 273 (1982), S. 37-42 
    Details
    ISSN: 1432-069X
    Keywords: Lymphoma ; Cutaneous lymphoma ; T cell ; Vitamin A and synthetic retinoids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 77-year-old woman developed a diffuse nodular eruption with histologic, ultrastructural, and biologic evidence of cutaneous T-cell lymphoma (CTCL) limited to the skin. She was treated with a new aromatic retinoid Ro 10-9359 (1 mg/kg/day). After 34 days, the lesions flattened completely and the mononuclear cell infiltrate decreased significantly. No clinical recurrences occured after a 4-month survey. Discontinuation of the aromatic retinoid led to a relapse with identical clinical and histologic features.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00509025
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  • 2
    Electronic Resource
    Electronic Resource
    Epidermodysplasia verruciformis induced by a new human papillomavirus (HPV-8) (1982)
    Springer
    Archives of dermatological research 274 (1982), S. 213-219 
    Details
    ISSN: 1432-069X
    Keywords: Epidermodysplasia verruciformis ; Human papilloma virus ; T-Suppressor cells ; Monoclonal antibodies ; Synthetic retinoids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A new case of epidermodysplasia verruciformis (EV) is reported in a 35-year-old man characterized by multiple common warts, flat warts, psoriasis-form lesions, and pityriasis-versicolor-(PV) like lesions. There was no familial history, no mental retardation, and no malignant changes. Human papilloma virus type 8 was identified in PV-like lesions. Immunologic studies detected no abnormalities: Delayed skin tests, DNCB sensitization, levels of immunoglobulins, complement components, circulating immune complexes, number of circulating lymphocytes, lymphocyte membrane markers, proliferative responses to mitogens, Ts activity, and Ts subpopulations as detected by monoclonal antibodies were considered to be within normal limits. A treatment with a retinoid aromatic (RO 10-9359) improved the clinical status of the patient and did not modify the immune parameters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403724
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  • 3
    Electronic Resource
    Electronic Resource
    Cold-reactive antinuclear IgM (1980)
    Springer
    Archives of dermatological research 269 (1980), S. 325-327 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406426
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  • 4
    Electronic Resource
    Electronic Resource
    Detection of herpes simplex virus DNA in a cutaneous squamous cell carcinoma by in situ hybridization (1989)
    Springer
    Archives of dermatological research 281 (1989), S. 333-335 
    Details
    ISSN: 1432-069X
    Keywords: Squamous cell carcinoma ; Herpes simplex virus ; In situ hybridization ; Virus and cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of a cutaneous squamous cell carcinoma (SCC) occurring at the site of a long-standing recurrent HSV infection is described. No deficit of the cell-mediated immunity was recorded. HSV2 was isolated in several viral cultures. HSV DNA was visualized in the SCC by in situ hybridization with biotinylated probes in paraffin-embedded tissue. The samples were negative for HPV2, 5, 16, and 18 probes. A causal relationship between HSV infection and cutaneous SCC is hypothesized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412977
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  • 5
    Electronic Resource
    Electronic Resource
    Modulation of substance P and somatostatin receptors in cutaneous lymphocytic inflammatory and tumoral infiltrates (2001)
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 15 (2001), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The expression of receptors for neuropeptides in the skin is modified in skin diseases.〈section xml:id="abs1-3"〉〈title type="main"〉ObjectiveWe studied the cutaneous expression of substance P (SP) and somatostatin (SOM) receptors (SPR and SSTR, respectively) in skin affected by cutaneous inflammatory or tumoral T-cell infiltrates because these two neuropeptides are the ones most involved in inflammation.〈section xml:id="abs1-4"〉〈title type="main"〉MethodsWe revealed expression of these receptors using a binding in situ technique that gave highly specific results. Skin biopsies were incubated with biotinylated neuropeptides (SP or SOM).〈section xml:id="abs1-5"〉〈title type="main"〉ResultsIn normal skin, SSTR were observed on blood vessels, smooth muscle fibres and sweat glands. SSTR expression was modified only when expressed by keratinocytes in Ofuji papuloerythroderma and by plasmocytes in plasmocytoma. SPR distribution was not modified in subjects with atopic dermatitis or lupus. The expression of SPR in the epidermis was diminished in Ofuji papuloerythroderma and parapsoriasis and absent in mycosis fungoides.〈section xml:id="abs1-6"〉〈title type="main"〉ConclusionsThese results suggest that malignant lymphocytic infiltrates can inhibit SPR expression on keratinocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-3083.2001.00259.x
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  • 6
    Electronic Resource
    Electronic Resource
    Cutaneous metastasis of hepatocellular carcinoma diagnosed with hepatocyte paraffin (Hep Par 1) antibody immunohistochemistry (2003)
    Oxford, UK : Munksgaard International Publishers
    Journal of cutaneous pathology 30 (2003), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cutaneous metastases from hepatocellular carcinomas are rare, and their diagnosis may be difficult on histological grounds. We report a case of metastatic hepatocellular carcinoma to the skin that was confirmed immunohistochemically by the expression of a hepatomitochondria-specific antigen detectable on paraffin-embedded sections (Hep Par 1).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0560.2003.00128.x
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  • 7
    Electronic Resource
    Electronic Resource
    Huan normal dermal fibroblasts express somatostain receptors (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 8 (1999), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The hormone/neuropeptide somatostatin (SOM) exerts multiple functions in the central nervous system, the immune system, the hypothalamo-pituitary axis, the gastrointestinal tract, and the pancreas. Endogenous SOM occurs in 2 biologically active forms, with 14 or 28 amino acids. Five subtypes of SOM reporters have been cloned. SOM is present in human skin. We have investigated the expression of SOM receptors on human dermal normal fibroblasts. Biotinyl-SOM allowed the visualization of SOM receptors on human dermal fibroblasts. Radioligand binding with (3-[125I]iodotyrosy]11)-SOM-14 were performed on these cells and the effect of SOM-14 on the DNA synthesis by fibroblasts was evaluated by measuring [3H]-methyl thymidine incorporation. Saturation curve, and Scatchard plot showed a homogeneous class of receptors with a Bmax of 0.055±0.023 nM and KD of 2.0±0.4 nM (values: mean±SEM). Fibroblasts expressed 3,317±1,385 binding sites per cell. Commpetitive displacement experiments showed that SOM-14 IC50 was 69.3±4.5 nM (mean±SEM), for SOM-28 33.2±6.0 nM and for octreotide 36.5±3.3 nM. The KI values calculated from these IC50 were, respectively: 62.4±4.1 nM; 29.9±5.4 nm; 32.9±2.9 nM. We conclude that subtype 2 or 3 SOM receptros is present on human normal dermal fibroblasts. A weak effect of SOM-14 on DNA synthesis was observed with SOM concentrations of 10-7 and 10-6 M.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1999.tb00381.x
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  • 8
    Electronic Resource
    Electronic Resource
    Melanocyte-lymphocyte interaction in human graft-versus-host disease (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 10 (1983), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Pigmentary disorders in chronic human GvHD comprise reticular or diffuse hyper-and hypopigmentation and seem to result from an interaction between lymphocytes and melanocytes. This interaction could be visualized by standard microscopy with a specific staining for melanin. The main ultrastructural findings were, in hyperpigmented areas: broad contact between melanocytes and lymphocytes, numerous and packed melanosomes, presence of cytoplasmic lipid droplets; in hypopigmented areas: disintegrating melanocytes with large intercellular spaces, small melanosomes, numerous lipid droplets, vacuolated organelles, as well as condensed and convoluted nuclei. Different hypotheses to explain the dysfunction of melanocytes are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1983.tb00332.x
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  • 9
    Electronic Resource
    Electronic Resource
    Sclerosing lipogranuloma of the male genitalia: ultrastructural study (1981)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 105 (1981), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Ultrastructural study of a case of sclerosing lipogranuloma showed a predominantly histiocytic-like cell infiltrate with numerous intracytoplasmic vacuoles of varied sizes without any limiting membrane and located in the deep dermis and subcutaneous fat. Fibroblasts appeared normal. Polymorphonuclear cells and macrophages were absent. This appearance was different from that described in ‘classical’ phagocytosis, mucopolysaccharidoses or polyvinylpyrrolidone storage syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1981.tb00777.x
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  • 10
    Electronic Resource
    Electronic Resource
    Verruciform xanthoma of the scrotum in a renal transplant patient (2004)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 150 (2004), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2004.05752.x
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