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  • 1
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The efficacy and safety of long-acting propranolol (LA.P), 160 mg once-daily, in the prophylactic treatment of migraine have been tested against placebo in a multicentric, double-blind, randomized study. The two groups are compared in a parallel manner over a treatment period of 12 weeks, following a 4-week placebo run-in period. Fifty-five of the 74 patients who entered the trial were included at the end of the run-in period. Forty-one patients completed the study. None of the 14 patients who withdrew from the study did so because of side effects. The statistical analysis was done according to the “intention to treat” principle. LA.P was significantly more effective than placebo in reducing the frequency of migraine attacks (p=0.01 by variance analysis). LA.P reduced the average number of monthly crises by 48% on day 84. There was a slight but significant reduction of the systolic blood pressure and heart rate in the erect position, but there was no significant difference between LA.P and placebo regarding either the number of complaints or the number of side effects elicited out of a 17-item questionnaire. None of the observed side effects led to a withdrawal from treatment.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Chemical Physics Letters 179 (1991), S. 422-428 
    ISSN: 0009-2614
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 513 (1987), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 215 (1977), S. 209-219 
    ISSN: 1432-1459
    Keywords: Pineal gland calcification ; Low temperature ashing ; Trace elements ; Scanning electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird ein allgemeines Schema für die Analyse kleiner Verkalkungen vorgelegt. Nach Veraschung bei niedriger Temperatur werden die Proben chemisch, in ihrer Struktur und morphologisch untersucht unter Verwendung von atomarer Absorptionsspektrometrie, Infrarotspektrometrie, Röntgendifraktion und Scanning Elektronenmikroskop. Es werden detailliert die Ergebnisse beim Studium von Verkalkungen der menschlichen Epiphyse dargelegt. Der Gehalt an Spurenelementen ist sehr hoch, jedoch innerhalb der Normgrenzen bei anderen biologischen Apatiten. Es wird gefolgert, daß die Verkalkungen der Epiphyse häufiger sind, als bisher angenommen wurde.
    Notes: Summary A general scheme of analysis for the investigation of minute calcification is presented. After low temperature ashing, the samples are subjected to chemical, structural and morphological study, using atomic absorption spectrometry, infrared spectrometry, X-ray diffraction and scanning electron microscopy. Details about the calcification of the human pineal gland are given. The content of trace elements is very high, but within the limits found in other biological apatites. It is concluded that calcification of the pineal is a more general occurrence than has been realized.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1459
    Keywords: Calcification of choroid plexus ; Low temperature ashing ; Scanning electron microscopy ; Trace elements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Plexus chorioidei menschlicher Gehirne wurden bei niedriger Temperatur verascht, um die Verkalkungen zu isolieren. Der Aschenrückstand wurde dann morphologisch, chemisch sowie in bezug auf seine Struktur mit Hilfe von Scanning-Elektronenmikroskopie, Atomabsorptionsspektrometrie mit und ohne Flamme sowie infraroter Spektrometrie und Röntgendiffraktionsmethode untersucht. Morphologisch bestanden die Verkalkungen aus aufgewickelten Fasern, die Granula mit einem Durchmesser zwischen 0,05 und 0,15 mm bildeten. Diese bestanden aud kristallinem Ca3(PO4)2 und Hydroxylapatit. Der Gehalt an Spurenelementen ist hoch, jedoch innerhalb der bei anderen biologischen Apatiten üblichen Grenzen. In einzelnen Fällen allerdings überschreitet der Eisengehalt diese Grenzwerte.
    Notes: Summary Human choroid plexus was submitted to low temperature ashing (LTA) in order to isolate the calcification. The ashing residue was then subjected to morphological, chemical and structural studies using technics such as scanning electron microscopy, flame and flameless atomic absorption spectrometry, infrared spectrometry and X-ray diffraction. Morphologically, the calcification consisted of wound-up fibers forming granules with a diameter of 0.05 to 0.15 mm. The concretions were identified as cristalline Ca3(PO4)2 and hydroxylapatite. The content of trace elements was high, but within the limits found in other biological apatites. In some cases, however, the Fe content exceeded these limit values.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 236 (1989), S. 309-310 
    ISSN: 1432-1459
    Keywords: Multiple sclerosis ; HLA antigens ; Multiple sleep latency test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The role of HLA antigens, and HLA-DR2 in particular, in the determination of mean sleep onset latencies (MSOLs) in multiple sclerosis (MS) was studied. It has been suggested that this antigen may play a part in the reduction of MSOLs, since nearly 100% of patients suffering from narcolepsy are DR2-positive. A multiple sleep latency test was performed in 37 patients suffering from MS without spontaneous complaints of sleep disturbances and who were typed for HLA-A, B, C, DR and DQ. The MSOL was reduced in a total of 21 patients, in only 7 of 15 DR2-positive patients and in 12 of 21 DQw1-positive patients. However, it was reduced in 13 of 16 B8- or B14-positive patients. In contrast with this, in the absence of an early sleep onset (MSOL 〉30 min), no HLA antigens were found to be over-represented when considered individually; only those patients positive for a group of cross-reacting HLA antigens (B5, B15, B18, B21 or B35) had an MSOL greater than 30min. These results suggest that the genes which code for the DR2 or DQw1 antigens, which are present in nearly 100% of narcoleptics, are not solely responsible for the appearance of an early sleep onset in MS.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 1 (1965), S. 557-562 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Social psychiatry and psychiatric epidemiology 22 (1987), S. 85-92 
    ISSN: 1433-9285
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé La tentative de suicide peut Être considérée comme une solution désespérée apportée à des problèmes psychologiques, familiaux et sociaux complexes. Notre travail porte sur quinze familles dont un jeune membre fut admis à l'hÔpital général pour tentamen. Son but était l'étude clinique de la structure familiale, ainsi que celle des transactions se déroulant au sein de ces familles. Nous nous sommes limités à des familles de jeunes suicidants, en raison de l'importance de cette phase du cycle vital, tant pour le développement individuel que pour celui de la famille. Nous avons recensé les données socio-démographiques, ainsi que les plaintes et les symptÔmes présentés tant par le suicidant que par d'autres membres de la famille. L'appréciation de la famille fut établie à l'aide d'une version simplifiée de la grille d'évaluation de Yale. Nos résultats sont comparables à ceux présentés par Richman (1979) et Pfeffer (1981). Voici les plus importants: toutes les familles se sont avérées chroniquement dysfonctionnelles. La plupart présentent un chaos hiérarchique; des barrières générationnelles floues; une surprotection mutuelle par le biais du secret; un isolement autant à l'intérieur qu'à l'extérieur de la famille; une rigidité de l'organisation familiale et des “patterns” transactionnels; une capacité insuffisante de résoudre des conflits. Nous pensons pouvoir ajouter l'importance et la chronicité des relations symétriques. Certaines familles se querellent à propos de tout et de rien, d'autres font preuve d'un style dépressif et gèlent indéfiniment disputes et conflits.
    Notes: Summary Suicide attempt can be considered as a hopeless issue out of diverse and complex psychological, familial and wider social problems. The aim of this preliminary clinical study was to examine first the family structure and second the transactions occurring in fifteen families with one young hospitalized in a general hospital for suicide attempt. Young suicide attempters were chosen because of the importance of this stage of life cycle for the development of both the individual and his family. Sociodemographic data were registered and patients' complaints as well as symptoms of other members of the family were recorded and diagnosed. For family evaluation we used a simplified Yale family assessment grid. Our results are comparable with those found by Richman (1979) and Pfeffer (1981). The main results that we have pointed out are: each family was chronically dysfunctional. Almost all presented: hierarchical chaos, no overt leadership; enmeshment, especially blurred generation boundaries; over protectiveness through secret keeping; isolation within and outside of the family; rigidity of the family organization and of the transactional patterns; insufficient conflict resolution, even conflict avoiding. We would add the very importance and the chronicity of symmetrical relationships. Some families are quarreling about everything and nothing, others show depressive style and freeze indefinitely any kind of dispute and conflict.
    Type of Medium: Electronic Resource
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