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A One-Dimensional (Proton and Phosphorus) and Two-Dimensional (Proton) In Vivo NMR Spectroscopic Study of Reversible Global Cerebral Ischemia (1996)

Brulatout, S. ; Méric, Ph. ; Loubinoux, I. ; [et al.]

Oxford, UK : Blackwell Science Ltd

Journal of neurochemistry 66 (1996), S. 0

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ISSN: 1471-4159

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Abstract: The suitability of two-dimensional (2D) proton spectroscopy for monitoring, in vivo, the changes in levels of brain metabolites induced by cerebral ischemia was investigated in an experimental model of 30-min reversible ischemia induced by four-vessel occlusion in the rat. The resulting data were compared with those obtained by one-dimensional (1D) proton and phosphorus spectroscopy. Phosphorus spectra obtained during ischemia showed significant drops in levels of phosphocreatine (−73%), β-ATP (−60%), and intracellular pH (to 6.30) and an increase in inorganic phosphate level (905%). 1D and 2D proton spectra showed decreases in the N-acetylaspartate/creatine-phosphocreatine ratio that were not significantly different [−21% (1D) and −32% (2D)]. Similarly, the increases in lactate/creatine-phosphocreatine ratio were not significantly different [2,546% (1D) and 3,020% (2D)]. 2D spectroscopy also indicated a decrease in aspartate (−66%) and an increase in the inositol-choline derivative (+124%) pools during ischemia and an increase in alanine pool (+516%) during reperfusion. The glutamate-glutamine pool and taurine content did not change significantly during ischemia but decreased during reperfusion. The glucose level transiently decreased (−67%) during ischemia and increased immediately after (+261%). The levels of all the metabolites investigated returned to control values within 175 min after ischemia. 2D spectroscopy seems to be a reliable method of monitoring the changes in levels of cerebral compounds known to be involved in ischemia.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1046/j.1471-4159.1996.66062491.x

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Analytical problems associated with the noninvasive measurements of cerebral blood flow in cerebrovascular diseases (1980)

Seylaz, J. ; Meric, P. ; Correze, J. L. ; [et al.]

Springer

Medical & biological engineering & computing 18 (1980), S. 39-47

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ISSN: 1741-0444

Keywords: Cerebral blood flow ; Isotope clearance ; Noninvasive technique

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology , Medicine

Notes: Abstract The validity of atraumatic measurements of regional cerebral blood flow (r.c.b.f) by intravenous injection of Xenon 133 has been studied in 17 patients with cerebrovascular diseases. The results were directly compared with those obtained in the same subjects using the intracarotid-injection method. Clearance curves obtained by the intravenous method were analysed by means of a bicompartmental model of blood circulation corrected for recirculation of the tracer. Use of different modes of intravenous injection and systematic analysis of the portion of the clearance curve usable for estimation of regional cerebral blood flow enabled the authors to define the optimal conditions for measurement of r.c.b.f. in subjects with cerebrovascular disorders. A predominant source of error was found to be the difficulty in defining the exact instant when clearance begins. As a result, the best conditions were as follows: slow injection (1 min) of tracer and analysis of the portion of clearance curve between 3 and 11 min after the beginning of the clearance. Under these conditions this atraumatic method is as precise in subjects with cerebrovascular disease as in those with normal cerebral circulation.