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  • 1
    Electronic Resource
    Electronic Resource
    Gap junctional intercellular communication of cultured rat liver parenchymal cells is stabilized by epithelial cells and their isolated plasma membranes (1994)
    Springer
    Cellular and molecular life sciences 50 (1994), S. 124-126 
    Details
    ISSN: 1420-9071
    Keywords: Rat hepatocyte ; gap junctional intercellular communication ; coculture ; plasma membrane ; stabilization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The gap junctional intercellular communication (GJIC) determined by measuring dye coupling with Lucifer yellow, decreased within 3 d from 66% to 28% in monocultures of rat liver parenchymal cells. Coculturing of the parenchymal cells with a nonparenchymal epithelial cell line from rat liver resulted in increased and stabilized intercellular communication (83% after 3 d). The presence of isolated plasma membrane vesicles of the nonparenchymal epithelial cells also stabilized the intercellular communication between the liver parenchymal cells (70% after 3 d). When liver parenchymal cells were cocultured with a rat liver fibroblast cell line the gap junctional communication between the parenchymal cells was not stabilized (43% after 3 d), and isolated plasma membrane vesicles of the fibroblast were also unable to support the GJIC in parenchymal cells (35% after 3 d). It is concluded that plasma membrane constituents of the nonparenchymal epithelial cells were responsible for the stabilization of the GJIC between parenchymal cells. A heterotypic gap junctional communication between parenchymal and nonparenchymal cells was not observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01984948
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Tetrachloromethane metabolism in vivo under normoxia and hypoxia (1987)
    Springer
    Archives of toxicology 60 (1987), S. 115-121 
    Details
    ISSN: 1432-0738
    Keywords: Carbon tetrachloride ; Cytochrome P-450 ; Glucose-6-phosphatase ; Glucose-6-phosphate dehydrogenase ; Hepatotoxicity ; Histopathology of liver parenchym ; Hypoxia ; Tetrachloromethane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract About 250 μmol/kg tetrachloromethane is metabolized by male Sprague-Dawley rats receiving a dose of 500 μmol/kg by inhalation. Determination of enzyme activities and histopathological assessment show that various parameters reflecting cellular injury do not differ for the same amount of tetrachloromethane metabolized under different oxygen partial pressures. On the other hand, the amounts of ethane and pentane exhaled under hypoxic conditions are greater than under normoxia. The previously reported differences in the toxicity of tetrachloromethane upon exposure under normoxia or hypoxia seem to be mainly due to the different amounts of tetrachloromethane metabolized under both conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296962
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Sacroiliitis in sarcoidosis: Case reports and review of the literature (1995)
    Springer
    Clinical rheumatology 14 (1995), S. 695-700 
    Details
    ISSN: 1434-9949
    Keywords: Sarcoidosis ; Sacroiliitis ; Granulomatous Diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report the occurrence of bilateral sacroiliitis in 2 cases of biopsy-proven sarcoidosis. Tuberculosis was excluded by tuberculin testing and bronchoalveolar lavage in both cases. In the literature, 5 cases of sacroiliitis and sarcoidosis have thus far been described, but in all tuberculosis was not excluded (tuberculin testing was not performed or revealed a postive test result). In 1 of these cases tuberculosis was even simultaneously suspected to be present. In all previous cases, antituberculous or other antimicrobial agents were given. Previously reported cases of sacroiliitis in sarcoidosis are briefly reviewed, and possible relations between seronegative spondylarthropathies, slow bacterial infections, sarcoidosis and other granulomatous diseases are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02207939
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    Paper (German National Licenses)
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