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  • 1
    Electronic Resource
    Electronic Resource
    Influence of dehydrocholate sodium on the biliary reabsorption of sulfobromophthalein sodium from the rat biliary tree after retrograde intrabiliary injection (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 789-791 
    Details
    ISSN: 1432-1440
    Keywords: Decholin ; Bromsulfthalein ; Biliäre Rückresorption ; retrograde intrabiliäre Injektion ; Dehydrocholate sodium ; Sulfobromophthalein sodium ; Biliary reabsorption ; Retrograde intrabiliary injection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Biliary re-excretion of sulfobromophthalein sodium (BSP) (1.2 µmol/rat) after retrograde intrabiliary injection is markedly inhibited by dehydrocholate sodium (Decholin) given intravenously as a constant infusion (3.1 µmol/min/kg body weight) or as a bolus injection (24.8 µmol/rat) to rats. Most interestingly Decholin demonstrates the same inhibitory effects on the biliary re-excretion of BSP when it is administered by retrograde intrabiliary injection (24.8 µmol/rat) together with the dye. In contrast to the inhibition of biliary re-excretion of BSP its biliary reabsorption from the biliary tract seems to be rather increased: about 80–85% of 1.2 µmol BSP are reabsorbed in all sets of experiments with Decholin in comparison to about 65% to the control group. Combined with histological data it is suggested that reabsorption of BSP after retrograde intrabiliary injection occurs at the ductular site whereas re-excretion takes place at the cannalicular membrane of the hepatocyte.
    Notes: Zusammenfassung Die biliäre Reexkretion von Bromsulfthalein (BSP) (1,2 µmol/Ratte) wird nach retrograder Injektion in das Gallengangssystem der Ratte durch intravenöse Gabe von Decholin entweder als Infusion (3,1 µmol/min/kg Körpergewicht) oder als Bolusinjektion (24,8 µmol/Ratte) signifikant eingeschränkt. Decholin hemmt auch dann die biliäre Reexkretion von BSP, wenn 24,8 µmol/Ratte zusammen mit BSP retrograd injiziert werden. Die biliäre Rückresorption erscheint dagegen gesteigert: ca 80–85% von 1,2 µmol BSP werden nach retrograder Injektion in das Gallengangssystem der Ratte unter dem Einfluß von Decholin rückresorbiert im Vergleich zu ca 65% der Kontrollgruppe. Unter Berücksichtigung histologischer Befunde wird vermutet, daß BSP nach retrograder Injektion im duktulären Bereich des Gallengangssystems rückresorbiert wird, während die biliäre Reexkretion an der Canaliculusmembran des Hepatozyten stattfindet.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01614296
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  • 2
    Electronic Resource
    Electronic Resource
    H2-receptor antagonists and gastric mucosal damaging agents (1982)
    Springer
    Journal of molecular medicine 60 (1982), S. 158-158 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711280
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  • 3
    Electronic Resource
    Electronic Resource
    Biliary reabsorption of cholate sodium, glycocholate sodium, and taurocholate sodium from the rat biliary tree after retrograde intrabiliary injection (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 845-847 
    Details
    ISSN: 1432-1440
    Keywords: Retrograde intrabiliäre Injektion ; Biliäre Rückresorption ; Gallensalze ; Retrograde intrabiliary injection ; Biliary reabsorption ; Bile salts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The results demonstrate the biliary reabsorption of14C-cholate,14C-glycocholate, and14C-taurocholate from the rat biliary tree after retrograde intrabiliary injection. It could be shown that retrograde injection of these bile salts (20 nmol) in a total volume of 40 µl leads to significantly increased biliary reabsorption in contrast to the administration in a retrograde volume of only 20 µl. These differences in reabsorption may be explained by greater reabsorption at a more proximal site in the biliary tree. Furthermore14C-glycocholate and14C-taurocholate are reabsorbed to a lesser extent in contrast to14C-cholate when bile flow was restarted at once after retrograde injection in a volume of 40 µl. It is speculated that conjugation of cholate to glycine and taurine has some effect on the extent of biliary reabsorption of this bile acid. Following the results presented in this paper one might hypothize that biliary reabsorption has an important influence on bile composition i.e. the biliary excretion of bile salts.
    Notes: Zusammenfassung Die biliäre Rückresorption von14C-Cholsäure-Na,14C-Glycocholsäure-Na und14C-Taurocholsäure-Na nach retrograder Injektion in das Gallengangssystem der Ratte wird nachgewiesen. Bei retrograder Gabe von 20 nmol dieser Gallensalze in einem Volumen von 40 µl ist die biliäre Rückresorption signifikant erhöht im Vergleich zur Rückresorption nach retrograder Injektion dieser Gallensalze in nur 20 µl. Diese Unterschiede in der Rückresorption könnten durch eine gesteigerte Rückresorption in proximaleren Anteilen des Gallengangssystems erklärt werden.14C-Glykocholsäure-Na und14C-Taurocholsäure-Na weisen nach retrograder Injektion eine signifikant geringere Rückresorption auf als14C-Cholsäure. Es wird vermutet, daß durch die Konjugation der Cholsäure an Glycin und Taurin die biliäre Rückresorption dieser Gallensäure vermindert wird. Aufgrund der gefundenen Ergebnisse wird die Hypothese aufgestellt, daß die biliäre Rückresorption die biliäre Exkretion von Gallensalzen beeinflußt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01469307
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  • 4
    Electronic Resource
    Electronic Resource
    Comparison of the gastroduodenal tolerance of tenoxicam and diclofenac Na (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 419-421 
    Details
    ISSN: 1432-1041
    Keywords: Tenoxicam ; Diclofenac Na ; NSAID ; gastroduodenal damage ; side-effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The gastroduodenal tolerance of Tenoxicam and Diclofenac Na has been evaluated in a double-blind, parallel group study in 36 healthy male volunteers. The doses used were 20 mg Tenoxicam and 100 mg Diclofenac Na daily in a retard formulation for 14 days. Gastric tolerance was assessed by endoscopy, which was performed at base-line, after the 14 day dosing period and after a 14 day follow-up period without treatment. The mucosal lesions were scored using modified Lanza criteria. Tenoxicam was significantly better tolerated at the end of the 14 day dosing period (mean gastric score: Tenoxicam 1.3; Diclofenac Na 2.2). The two treatment groups had comparable scores at the base-line and post study assessments. Tenoxicam and Diclofenac Na were generally well tolerated. Only two volunteers reported intermittant lack of appetite, heartburn and a feeling of pressure in the stomach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558307
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  • 5
    Electronic Resource
    Electronic Resource
    Prophage lambda libraries for isolating cDNA clones by functional screening
    Amsterdam : Elsevier
    Gene 96 (1990), S. 205-211 
    Details
    ISSN: 0378-1119
    Keywords: Dicytostelium discoideum ; Recombinant DNA ; cAMP-binding proteins ; calmodulin-binding proteins ; expression vector ; ligand screening ; lysogeny ; phage λgt11 ; slime mold
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-1119(90)90254-O
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  • 6
    Electronic Resource
    Electronic Resource
    Computer generated quaternary phase-only holograms
    Amsterdam : Elsevier
    Physics Letters A 29 (1969), S. 301-302 
    Details
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0375-9601(69)90135-2
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  • 7
    Electronic Resource
    Electronic Resource
    Computer generated quaternary phase-only holograms
    Amsterdam : Elsevier
    Physics Letters A 29 (1969), S. 301-302 
    Details
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0375-9601(69)90135-2
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  • 8
    Electronic Resource
    Electronic Resource
    Light guidance and mode conversion in magneto-optic buried channel waveguides (1990)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 68 (1990), S. 3849-3855 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The optical and magneto-optical properties of weakly guiding single-mode buried channel waveguides in substituted yttrium iron garnet have been investigated experimentally. The propagation constant difference Δβ of the two coupled TE and TM modes, which is of particular interest for waveguide isolator application, is found to be strongly dependent on waveguide geometry. Measured results can be explained by the specific growth of the top cladding layer, which occurs into different crystallographic directions around the etched waveguide core. This leads to a local variation of the refractive index, which effects the guidance of light, and to a local variation of birefringence, which effects Δβ. The measured variation of Δβ is shown to be primarily caused by growth induced birefringence. It is demonstrated that Δβ can be controlled to small values at selectable waveguide widths as required for waveguide isolator application simply by an appropriate setting of fabrication parameters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.346270
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  • 9
    Electronic Resource
    Electronic Resource
    Yttrium iron garnet single-mode buried channel waveguides for waveguide isolators (1988)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 52 (1988), S. 682-684 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Magneto-optic single-mode buried channel waveguides in substituted yttrium iron garnet suitable for waveguide isolators have been prepared. The channels are fabricated in a three-step procedure: starting with multiple-layer planar single-mode waveguides, rib waveguides are wet etched and then overgrown with top cladding. Such waveguides show mode profiles well matched to that of single mode fibers. In mode conversion experiments, an extinction ratio of 20 dB was obtained. Waveguides coupled to single-mode fibers on both sides showed an overall insertion loss of about 4 dB.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.99346
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  • 10
    Electronic Resource
    Electronic Resource
    45° waveguide isolators with phase mismatch (1990)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 56 (1990), S. 1302-1304 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: 45° waveguide isolators based on magneto-optic channel waveguides with phase mismatch can be realized simply by choosing a proper orientation of the input polarization. This is demonstrated theoretically by visualizing the magneto-optic mode coupling as "coupling tracks'' on the Poincaré sphere, and is verified experimentally for real waveguides with considerable phase mismatch. More than 30 dB isolation is feasible in practical devices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.102501
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