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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Journal of oral rehabilitation 29 (2002), S. 0 
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Surface electromyography (EMG) allows the quantification of the occlusal equilibrium in dysfunctional patients, for instance in those with temporomandibular disorders (TMD). Fourteen patients (ten women, four men) with internal derangement type I were selected among the TMD patients referred to a private practice in Milan. A stabilization splint with posterior contacts was made for each patient. To verify the static neuromuscular equilibrium of occlusion, EMG activity of left and right temporal and masseter muscles was recorded in all patients and the activity (ratio between the activities of the temporal and masseter muscles) index was computed over a maximum voluntary clench test of 3 s. Muscular waveforms were also analysed by computing a percentage overlapping coefficient (POC, an index of the symmetric distribution of the muscular activity determined by the occlusion). The total electrical activity was measured by calculating the area under the entire muscular waveforms. In all patients EMG was performed just before and immediately after the insertion of the splint and data were compared by paired Student's t-tests. Overall, the splint reduced the electrical activity of the analysed muscles (P 〈 0·005) and made it more equilibrated both between the left and right side (larger symmetry in the masseter muscle POC, P 〈 0·05) and between the temporal and masseter muscles (activity index, P 〈 0·01).
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Journal of oral rehabilitation 31 (2004), S. 0 
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: summary  The assessment of bite forces on healthy single tooth appears essential for a correct quantification of the actual impact of single implant oral rehabilitations. In the present study, a new single tooth strain-gauge bite transducer was used in 52 healthy young adults (36 men, 16 women) with a complete permanent dentition. The influences of tooth position along the dental arch, of side, and of sex, on maximum bite force were assessed by an anova. No significant left–right differences were found. On average, in both sexes the lowest bite force was recorded on the incisors (40–48% of maximum single tooth bite force), the largest force was recorded on the first molar. Bite forces were larger in men than in women (P 〈 0·002), and increased monotonically along the arch until the first or second permanent molar (P 〈 0·0001). The present data can be used as reference values for the comparison of dental forces in patients.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Journal of oral rehabilitation 30 (2003), S. 0 
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: summary  To investigate the hypothesis of a functional coupling between occlusion and neck muscles, the immediate effect of asymmetrical occlusal interferences on the pattern of contraction of the sternocleidomastoid muscles (SCM) during maximum voluntary clench (MVC) was analysed in 30 healthy subjects. All subjects had a complete and sound permanent dentition, without temporomandibular joint (TMJ) and craniocervical disorders. A 5-s surface electromyogram (EMG) examination of the SCM was performed during (1) MVC in intercuspal position and (2) MVC with a single 200-μm occlusal interference alternatively positioned on teeth 16, 13, 23, 26. All subjects had a symmetrical EMG activity during MVC in intercuspal position. For each subject, SCM potentials were standardized as percentage of the mean potentials recorded during the MVC on natural dentition and the EMG waves of left- and right-side muscles were compared by computing the relevant percentage overlapping coefficient (POC). For each subject, the best and the worst POCs computed during the four MVC tests with occlusal interferences were found and the percentage difference between them was calculated. In the four MVC tests with occlusal interferences, SCM symmetry was very different from that recorded during MVC on natural dentition. The difference between the best and worst POCs computed within each subject was very variable, ranging from 1·52 to 41·57%. In conclusion, when young healthy subjects with a normal occlusion clench on an asymmetrical occlusal interference, they have an altered left-right side pattern of contraction of their SCM. In almost all subjects, a previously symmetrical pattern became asymmetrical.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  It has been demonstrated that cyclosporin A (CyA) blocks the immune system, acts on cytoskeleton and stimulates the production of extracellular matrix (ECM) and transforming growth factor-β1 (TGF-β1). This cytokine, such as transforming growth factor-α (TGF-α), induces deposition of glycosaminoglycans (GAG), proteoglycans and collagen fibres in the ECM.Methods:  In this work, we examined the effect induced by CyA, TGF-β1 and TGF-α on cultures of healthy and overgrown human gingival fibroblasts in order to evaluate the glycosaminoglycan, cytoskeletal changes and the behaviour of fibroblasts after concanavalin A (Con A) treatment. Moreover, we examined gingival biopsies by Alcian blue histochemical staining and electron transmission microscopy.Results:  Total and extracellular sulphated GAG in overgrown gingiva specimens and in derived fibroblast cultures treated with CyA and cytokines were significantly higher than controls. The action of cytokines was increased (P ≤ 0.01) compared with CyA with a greater effect of TGF-α in comparison with TGF-β1; the electron microscopy showed ECM accumulation. The agglutinations showed the heterogeneity of fibroblast populations.Conclusions:  Stimulation with Con A showed that the fibroblast population had cell surface heterogeneity, and could respond in a different way to both CyA and cytokine stimulus. Moreover, increased synthesis of GAG in overgrown gingiva compared with synthesis in normal fibroblasts before CyA treatment suggests a possible genetic origin of damage. As not all CyA-treated patients develop gingival overgrowth, a genetic predisposition may explain the different responses of gingival fibroblast populations.
    Type of Medium: Electronic Resource
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