ISSN:
1365-2842
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
Calcium-phosphate ceramic particulates are often used as filler material for enhanced repair of dental bone defects. Although evidence of bone ingrowth in the scaffold of these particles has been described, it is not observed consistently. Fibrous tissue often encapsulates these particles, which can subsequently become dispersed into the surrounding tissues or even exfoliated. The aim of the present study was to evaluate bioactive glass granules (Biogran ™)* as a filler for osseous lesions, and to compare them with two commercially available Hydroxylapatite (HA) granules. The particulates were implanted in the jaws of five beagle dogs, resected and evaluated after 1, 2, 3, 6 and 12 months of implantation. Histological analysis revealed an improvement in repair of all the lesions. A massive osteoconductive bone growth was seen near the walls of the bony cavities, but in greater amounts around the bioactive glass granules than around the HA materials. On top of this massive growth a trabecular bone growth was observed in the centre of the bony cavities. These trabeculae were associated with the glass particles, which exhibited osteophilic properties, while fibrous tissue separated the bone tissue from the HA particles. The centres of many of the particles are excavated, and are subsequently filled by newly formed bone tissue. This internally formed bone tissue is not necessarily connected to the surrounding bone tissue, and functions as a nucleation site for further bone repair. For the mesenchymal cells within the eroded glass particles this inner environment acts as a stimulus to differentiate into osteoblasts and to start their osteogenetic potential. This phenomenon was not observed around the HA materials. If the latter were surrounded by fibrous tissue, disintegration of the surface by giant cells was observed.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1365-2842.1991.tb01689.x
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