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  • 1
    Electronic Resource
    Electronic Resource
    The design of pharmacokinetic experiments for model discrimination (1984)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 12 (1984), S. 351-365 
    Details
    ISSN: 1573-8744
    Keywords: pharmacokinetics ; model discrimination ; experiment design ; information theory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The need for objective design of pharmacokinetic experiments aimed at model discrimination is argued. A sequential design strategy based on information theory is outlined. The characteristics of this strategy and its applicability to pharmacokinetic experiments is examined by means of computer simulated experiments. The limitations of the technique are discussed and alternative approaches outlined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01061725
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Estimation of noncompartmental parameters: A technical note (1989)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 17 (1989), S. 527-527 
    Details
    ISSN: 1573-8744
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01061463
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Estimation of noncompartmental parameters: A technical note (1989)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 17 (1989), S. 131-137 
    Details
    ISSN: 1573-8744
    Keywords: noncompartmental ; numerical integration ; interpolation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Noncompartmental pharmacokinetic parameters are usually expressed in terms of the area under the so-called first moment curve and the area under the plasma concentration-time curve. These areas are normally computed by numerical integration. There is an inconsistency in the way in which they are presently estimated. This inconsistency is detailed and a consistent approach to the computation of noncompartmental parameters is outlined. The difference between the two methods is illustrated using some data from the literature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01059092
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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