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The design of pharmacokinetic experiments for model discrimination (1984)

Lacey, Laurence ; Dunne, Adrian

Springer

Journal of pharmacokinetics and pharmacodynamics 12 (1984), S. 351-365

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ISSN: 1573-8744

Keywords: pharmacokinetics ; model discrimination ; experiment design ; information theory

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract The need for objective design of pharmacokinetic experiments aimed at model discrimination is argued. A sequential design strategy based on information theory is outlined. The characteristics of this strategy and its applicability to pharmacokinetic experiments is examined by means of computer simulated experiments. The limitations of the technique are discussed and alternative approaches outlined.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01061725

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