ISSN:
1420-9071
Keywords:
Epstein-Barr virus
;
beta-adrenergic receptors
;
cyclic AMP synthesis
;
forskolin
;
adenylate cyclase
;
lymphocytes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Beta-adrenergic-associated cyclic AMP accumulation was studied in intact lymphocytes before and after transformation with Epstein-Barr virus into immortal cell lines. Although a marked reduction in isoproterenol-stimulated cyclic AMP synthesis was observed in transformed cells, forskolin-stimulated cyclic AMP accumulation was preserved. A parallel loss of125-iodocyanopindolol binding sites suggests that the reduction in beta-adrenergic-stimulated AMP synthesis is due to receptor down regulation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01964803
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