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  • 1
    Electronic Resource
    Electronic Resource
    Non-invasive assessment of the antipsoriatic activity of fumaric acid derivatives (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Skin research and technology 1 (1995), S. 0 
    Details
    ISSN: 1600-0846
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background/aims: Noninvasive methods are introduced for the monitoring of healing of psoriasis. Fumaris acid derivatives (FAD) were used in the treatment of psoriasis vulgaris for more than 30 years, but the effectiveness of these drugs has remained controversial. The object was to study the efficacy of FAD in a prospective study including noninvasive techniques, which may allow more accurate assessment in a smaller patient group.Methods: High-frequency ultrasound including image analysis, and colorimetry was employed. 14 patients were treated for 20 weeks.Results: In the ultrasound image, acanthosis and inflammatory infiltrate of active psoriasis cause an echopoor area under the entry echo. Under theray, this echo area diminishes while its density increases. During healing, the decrease in redness could be quantified.Conclusions: Monitoring of the healing of psoriasis is possible with ultrasonography and colorimetry. Fumaric acid was found efficient and safe in the treatment of psoriasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0846.1995.tb00035.x
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  • 2
    Electronic Resource
    Electronic Resource
    A wound healing model with sonographic monitoring (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 18 (1993), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The methods used hitherto for quantification of skin repair processes only allow an examiner a two-dimensional assessment of superficial wound healing. With the recent advent of high frequency B-scan ultrasonography in dermatology it has become possible to follow the course of healing and evaluate the healing processes in deeper layers of the skin. In this investigation 80 patients received cryosurgery for treatment of basal cell carcinomas on the face or neck region. As the size of cryosurgical defects can be precisely controlled they are potentially useful as standardized wound healing models. The course of wound healing after cryosurgery using a digital ultrasound scanner (DUB 20, Taberna pro medicum, Lüneburg, Germany) was monitored. The usable depth of penetration of the echo signal is ≈200μm, the axial resolution ∼80 μm. The cryolesion and the repair processes were examined ultrasonographically and clinically over a period of at least 3 weeks or until the wound had completely healed. The depth of invasion and lateral extent of the basal cell carcinoma as well as the size of the induced cryolesion can be determined by ultrasound. The exudative phase after cryosurgery, with developing oedema and necrosis, can be quantified on the basis of the reduced reflectivity in the corium. The repair processes taking place in the region of necrosis can be visualized in the ultrasound scan. The ultrasonically monitored wound healing model which we have demonstrated is particularly suitable for investigating the efficacy of drugs which promote healing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1993.tb02174.x
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  • 3
    Electronic Resource
    Electronic Resource
    A quantitative freeze-etching study on the effects of cytochalasin B, colchicine and concanavalin A on the formation of intercellular contacts in vitro
    Amsterdam : Elsevier
    Experimental Cell Research 146 (1983), S. 361-369 
    Details
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-4827(83)90137-4
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  • 4
    Electronic Resource
    Electronic Resource
    Zyklische intravenöse Antibiose als effizientes Therapiekonzept des chronisch-rezidivierenden Erysipels (1999)
    Springer
    Der Hautarzt 50 (1999), S. 34-38 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Chronisch rezidivierendes Erysipel ; Zyklische intravenöse Antibiose ; Maschinelle Lymphdrainage ; Laser-Doppler-Perfusion-Imaging ; Key words Recurrent erysipelas ; Cyclic intravenous antibiotica ; Lymphatic drainage ; Laser-Doppler-Perfusion-Imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The treatment of choice for prevention of recurrent erysipelas is the long-term therapy with intramuscular penicillin. The results are often unsatisfactory. Usually erysipelas recurs when the treatment is stopped. The aim of the present study was to evaluate a new treatment regimen, consisting of intravenous penicillin combined with lymphatic drainage. Fifteen patients who had suffered from three or more episodes of erysipelas within the last two years received 10 Mega I.U. of penicillin per day over ten days every third month over a one year period (patients who were allergic to penicillin received erythromycin). Use of intravenous penicillin was combined with lymphatic drainage performed by a sequential pneumatic compressing device. The treatment results were assessed by clinical examination and laboratory tests as well as by laser Doppler imaging every third month. During the one year treatment period and a further year of follow-up, 14 of 15 patients had no recurrent erysipelas. Only a 65 year old patient suffering from Parkinson heart failure, chronic lymphedema and an extensive stasis ulcers had recurrent erysipelas. The present treatment regimen appears to be an effective therapy for prevention of recurrent erysipelas.
    Notes: Zusammenfassung Das chronisch rezidivierende Erysipel ist den bislang gebräuchlichen Therapieformen wie der Gabe von Depot-Penicillinen nur unbefriedigend zugänglich. In der vorliegenden Studie wurde untersucht, ob eine zyklische intravenöse Antibiose in Kombination mit einer intermittierenden maschinellen Lymphdrainage zu zufriedenstellenden Ergebnissen führen kann. Behandelt wurden 15 Patienten, die innerhalb von 2 Jahren mindestens 3 therapiebedürftige Erysipele entwickelt hatten. Über ein Jahr wurde alle 3 Monate eine intravenöse Antibiose (Penicillin G, 10 Mio. I.E./Tag, bei Penicillin-Allergie Erythromycin 2mal 1 g/Tag) in Kombination mit einer maschinellen Lymphdrainage über 10 Tage durchgeführt. Bei den Patienten wurden zu Beginn der Therapie sowie bei den 3monatigen Kontrollen der klinische Befund, die laborchemischen Entzündungszeichen (BSG, CRP) sowie die Hautdurchblutung mit Hilfe des Laser-Doppler-Perfusion-Imaging untersucht. Von 15 Patienten blieben 14 Patienten während der Therapiephase sowie ein Jahr danach erscheinungsfrei. Lediglich bei einer 65jährigen multimorbiden Patientin mit chronischem Lymphödem und ausgedehnten Ulcera crura venosa kam es zu einem Rezidiv des Erysipels, was auf unzureichende pflegerische Maßnahmen zurückgeführt wird. Insgesamt erscheint die zyklische (3monatige) intravenöse Antibiose ein effizientes Therapieregime bei chronisch rezidivierenden Erysipelen zu sein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050861
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  • 5
    Electronic Resource
    Electronic Resource
    Elucidation of the enigma of the “metaphase band” ofChlamydomonas reinhardtii (1990)
    Springer
    Protoplasma 156 (1990), S. 139-148 
    Details
    ISSN: 1615-6102
    Keywords: Chlamydomonas reinhardtii ; “Metaphase band” ; Microtubules ; Cytoskeleton ; 3-D reconstruction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Conventional, computer-aided, and morphometric analysis of ultrathin serial sections through cells at consecutive stages of mitosis has clarified several aspects of the morphogenesis of the socalled “metaphase-band” (=MB) inChlamydomonas reinhardtii. In contrast to the original interpretation, the MB is not a single set of 4 microtubules (=MTs). This erroneous impression is created by the transient spatial association of the two parental 4-membered microtubular flagellar roots. A long section of the roots, which are constituents of the flagellar basal apparatus and the cortical cytoskeleton at interphase, persists during mitosis. Each parental 4-membered root is tightly coupled to half of the bisected basal body complex, and each daughter cell receives one root. During migration of the bisected basal body-root complexes towards the nuclear poles during prophase, the two opposite roots are bent in the middle. Starting at these bent regions, the central thirds become parallelly aligned during metaphase. The roots shorten during anaphase elongation of the nucleus, which occurs without any further change in distance between the daughter basal body-root complexes. At anaphase de novo assembly of cytoplasmic MTs was observed. Two intracellular MT arrays, focussed at the roots like the cortical MTs, penetrate deeply into the cell. They are interpreted as the incipient cleavage MTs of the phycoplast, or radicoplast.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01560652
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  • 6
    Electronic Resource
    Electronic Resource
    Large amplitude dynamics of clusters and nuclei (1998)
    Springer
    Czechoslovak journal of physics 48 (1998), S. 715-724 
    Details
    ISSN: 1572-9486
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We discuss and compare the dipole resonance modes in nuclei and metal clusters under varying conditions: different excitation mechanisms in the case of nuclei, changed background structure in the case of clusters. The resonances are generally nicely harmonic modes, even those with a large amplitude. Only extreme shapes, as they occur in fusion and fission, can perturb this harmonicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1021406109605
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  • 7
    Electronic Resource
    Electronic Resource
    The development of the diencephalic choroid plexus in the chick (1981)
    Springer
    Cell & tissue research 219 (1981), S. 297-311 
    Details
    ISSN: 1432-0878
    Keywords: Choroid plexus (chick) ; Third ventricle ; Ependyma ; Development ; Scanning electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The surface morphology of the diencephalic choroid plexus (Pl. ch. v. III) was investigated by light microscopy and scanning electron microscopy in chicks from the 7th embryonic day (ED) to the 8th week after hatching. Pl. ch. v. III develops on the anterior ventricular roof from a sagittally oriented fold and a few posteriorly located transverse folds. On the 7th ED no significant differences in the cell surface morphology between Pl. ch. v. III and the surrounding ependyma are observed: both are covered with cilia. During the next four days, long cell prolongations (one per cell) covered with microvilli develop first on the surface of the posterior ventricular roof and then on the posterior part of Pl. ch. v. III. These structures are transitory. On the 11th ED, round cell prolongations (one per cell) appear progressively on the entire plexus, also replacing the long ones. Now the plexus surface is distinct from the surface of the surrounding ependyma. During the last week before hatching and also after hatching, the round cell prolongations become less prominent. Simultaneously, the number of cilia per unit surface area diminishes. With consideration of earlier reports, this study suggests that the following factors are involved in the increase of the surface area of Pl. ch. v. III: (I) The pseudostratified epithelium changes into columnar epithelium. (2) Ependymal elements of the posterior roof of the 3rd ventricle contribute to the anlage of Pl. ch. v. III. In later stages, however, Pl. ch. v. III grows only by mitoses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00210150
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  • 8
    Electronic Resource
    Electronic Resource
    Regional surface changes during the development of the telencephalic choroid plexus in the chick (1983)
    Springer
    Cell & tissue research 231 (1983), S. 251-263 
    Details
    ISSN: 1432-0878
    Keywords: Choroid plexus (chick) ; Lateral ventricle development ; Epiplexus cells ; Scanning electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The surface morphology of the developing chick telencephalic choroid plexus (TCP) was examined by scanning electron and light microscopy. A blunt evagination develops rostro-cranially to the foramen of Monro on the medial telencephalic septum. The pseudostratified TCP epithelium differs in its surface morphology from that of the surrounding ependyma. Subsequently the TCP becomes elongated and branches. On the 9th embryonic day (ED) the pseudostratified epithelium progressively becomes high columnar epithelium in a distal to proximal direction along the branches of the TCP. The apical poles of the high columnar epithelial cells protrude into the ventricular lumen. Later, additional branches sprout at the base of the TCP, which then resembles a tree with a bush growing at its roots. Before the time of hatching, the high columnar epithelium changes to low columnar epithelium again in a distal to proximal direction. The surface of the TCP becomes flatter, in the process of which the number of cilia per unit surface area is reduced. On the developing TCP the epiplexus cells vary in shape, depending upon their functional state. It is proposed that not only the morphological but also the functional differentiation of the TCP proceeds in a distal to proximal direction along the branches of the choroid plexus. The surface differentiation of the TCP has a more regular character than that of the diencephalic CP (DCP), described previously, which seems to be influenced in its development by other anatomical structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222178
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