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  • 1
    Electronic Resource
    Electronic Resource
    Reactions to Penicillamine: A Case of Cutis Laxa, Elastosis Perforans Serpiginosa and “Pseudo” Pseudoxanthoma (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Journal of cutaneous pathology 32 (2005), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This patient was a 61-year-old white female who received several years of penicillamine therapy for the treatment of cystinuria. She subsequently developed penicillamine induced cutis laxa, elastosis perforans serpiginosa, and pseudoxanthoma elasticum like skin lesions. In addition, she suffered from numerous chronic bilateral lower extremity skin ulcerations. Her past medical history was also significant for end stage renal disease requiring hemodialysis and pulmonary fibrosis. She presented to the University of Miami Wound Care Center in 1/04 for treatment of her chronic ulcerations. On physical examination, the patient had multiple large hyperpigmented plaques with central ulcerations on her lower extremities. Some of the ulcers had overlying crust and others were covered with yellow fibrinous tissue. She also had generalized thickened, lax skin with multiple folds. On her neck, thighs, back and arms were violaceous, atrophic, serpiginous plaques with peripheral crusted erosions. A biopsy taken from the patients left thigh revealed dermal elastosis and the features of pseudo-pseudoxanthoma. Two additional biopsies taken from the left thigh demonstrated elastosis perforans serpiginosa. This case highlights multiple skin manifestations of penicillamine therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0303-6987.2005.320bw.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cutaneous Rhizopus in an Immunosuppressed Patient (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Journal of cutaneous pathology 32 (2005), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The patient is an eight-year-old white male with a prior history of a small bowel transplant secondary to gastroschisis and a history of chronic rejection. He was admitted to the hospital to rule out rejection of his second small bowel transplant. During the admission he developed painful erythematous plaques with necrosis and hemorrhagic bullae on his left knee and left neck. Dermatology was consulted and biopsies and tissue cultures were obtained. On H&E there were multiple thick walled non-septate hyphae and the GMS stain showed right angle irregular branching hyphae with an affinity for blood vessels. A further work-up for disseminated disease was negative. The patient was diagnosed with cutaneous mucormycosis. The patient underwent extensive surgical debridement and was started on Ambisone and treated for six months with resolution. Primary cutaneous mucormycosis is a rare opportunistic deep fungal infection. It is the most acute and fatal of all fungal infections. There are multiple associated conditions including immunosuppression. This disease can be controlled with early diagnosis and a combination treatment plan. There are only a few reported cases in the pediatric population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0303-6987.2005.320fz.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Mucocutaneous pigmented macule as a result of zinc deposition (2002)
    Oxford, UK : Munksgaard International Publishers
    Journal of cutaneous pathology 29 (2002), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Mucocutaneous depositions of various metals such as silver, lead, gold, arsenic, mercury, iron, and bismuth have been previously published. Heavy metal deposition typically occurs in the setting of either prolonged topical application to intact skin, topical application to eroded or ulcerated skin, as a result of either parenteral administration, or due to penetrating traumatic exposure.Method:  We report a unique case of mucocutaneous pigmentation occurring in a snow skier after topical application of a zinc-containing sunblock. Formalin-fixed paraffin-embedded tissue was utilized for electron microscopy.Result:  Backscatter electron imaging and energy dispersive spectroscopy revealed that the dominant metal present was zinc.Conclusions:  Mucocutaneous deposition of metals is enhanced by damage to the surface epithelium. Metal-containing topical agents, although commonly used, may rarely result in a permanent pigmentary alteration. We believe similar cases of mucocutaneous deposition of zinc exist; however, as these may be currently misdiagnosed as amalgam tattoos, the true incidence of this disorder is presently undefined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0560.2002.291008.x
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  • 4
    Electronic Resource
    Electronic Resource
    Successful treatment of extramammary Paget's disease of the scrotum with imiquimod 5% cream (2003)
    Oxford, UK : Blackwell Publishing
    Clinical and experimental dermatology 28 (2003), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Extramammary Paget's disease (EMPD) of the skin is an uncommon malignancy involving the epidermis, which sometimes extends into the dermis. Current treatments for EMPD are surgical excision, Mohs' micrographic surgery or laser ablation. We report a case of a 68-year-old male who presented with recurrent EMPD. The patient refused to have surgery and, as an alternative, he applied imiquimod 5% cream, an immune response modifier, daily for a total of 6 weeks. During the initial weeks of therapy, he experienced moderate erythema. Imiquimod treatment resulted in clinical and histological eradication of EMPD, with no recurrence observed during 6 months of follow-up.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2230.28.s1.12.x
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    Paper (German National Licenses)
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