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  • 1
    ISSN: 0942-0940
    Keywords: Keywords: Acoustic neuroma; cranial nerve preservation; Gamma Knife; stereotactic radiosurgery; vestibular schwannoma.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary ¶ From April 1992 till December 1998 stereotactic radiosurgery (Gamma Knife) was applied to 192 patients with vestibular schwannomas. 56 of them had radiosurgery as primary treatment modality and were followed-up for at least 4 years (48–80 months, median 62).  Without fatal complications, control of tumour growth was achieved in all but three cases, useful hearing being preserved in more than one half of the patients (62%). The neurological state improved in 30 patients (54%). Irradiation-associated adverse effects (18%) comprised neurological signs (incomplete facial palsy, four cases (two recovered completely), and mild trigeminal neuropathy, three cases, respectively) and morphological changes (three patients) marked by an enlargement of pre-existing cystic components calling for additional surgical treatment: Microsurgical decompression was performed in two cases, the third patient underwent a shunting procedure because of hydrocephalus formation.  Based on the present data, radiosurgery represents an effective treatment for vestibular schwannomas associated with an exceptionally low mortality rate and a good quality of life. With respect to the preservation of cranial nerve function, results are comparable to microsurgical resection. A short duration of hospitalization and a quick return to normal activities constitute further advantages and contribute to cost effectiveness in public health care.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 141 (1999), S. 811-818 
    ISSN: 0942-0940
    Keywords: Keywords: Gamma knife; stereotactic radiosurgery; glomus jugulare tumour; paragangliomas.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  The aim of this clinical study was to determine the tumour control rate, clinical outcome and complication rate following gamma knife treatment for glomus jugulare tumours. Between May 1992 and May 1998, 13 patients with glomus tumours underwent stereotactic radiosurgical treatment in our department. The age of these patients ranged from 21 to 80 years. The male : female ratio was 2 : 11. Six patients had primary open surgery for partial removal or recurrent growth and subsequent radiosurgical therapy. Radiosurgery was performed as primary treatment in 7 cases. The median tumour volume was 6,4 cm3 (range: 4,6–13,7 cm3). The median marginal dose applied to an average isodose volume of 50% (30–50%) was 13,5 Gy (12–20 Gy). In 10 patients, a total of 48 MRI and CT follow-up scans were available. The remaining three patients have been excluded from the postradiosurgical evaluation since the observation time (t〈12 months) was too short or patients were lost to follow up. The median interval from Gamma Knife treatment to the last radiological follow-up was 37,6 months (5–68 months). In 4 patients (40%) decreased tumour volumes were observed and in 6 cases (60%) the tumour size remained unchanged. Neurological follow-up examinations revealed improved clinical status in 5 patients (50%), a stable neurological status in 5 patients (50%) and no complications occurred. According to our preliminary experience Gamma Knife radiosurgery represents an effective treatment option for glomus jugulare tumours.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0942-0940
    Keywords: Keywords: Radiosurgery; gamma knife; glomus jugulare tumour.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary ¶ Leksell Gamma Knife was used to treat 66 patients with glomus jugulare tumour at 6 European sites between 1992–1998. The age of the patients ranged between 18–80 years (median 54 years). Gamma Knife radiosurgery was a primary treatment in 30 patients (45.5%). Open surgery preceded radiosurgery in 24 patients (36.4%), embolisation in 14 patients (21.2%) and fractionated radiotherapy in 5 patients (7.6%). The volume of the tumour ranged 0.5–27 cm3 (median 5,7 cm3). The minimal dose to the tumour margin ranged between 10–30 Gy (median 16.5 Gy).  After radiosurgery 52 patients were followed, the follow up period was 3–70 months (median 24 months). Neurological deficit improved in 15 patients (29%) and deteriorated in 3 patients (5,8%), one transient and two persistant. Neuroradiological follow up using MRI or CT was performed in 47 patients 4–70 months (median 24 months) after radiosurgery. Tumour size decreased in 19 patients (40%) while in the remaining 28 patients (60%) no change in the tumour volume was observed. None of the tumours increased in volume during the observation period. Control angiography was performed in 6 patients. Pathological vascularisation completely disappeared in one patient, reduced in two and there was no change in the remaining three.  Radiosurgery proves to be a safe treatment for glomus jugulare tumour with no mortality and no acute morbidity. Because of its naturally slow growth rate, up to 10 years of follow up will be necessary to establish a cure rate after radiosurgery for these lesions.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 139 (1997), S. 923-927 
    ISSN: 0942-0940
    Keywords: Basilar artery ; fenestration ; subarachnoid hemorrhage ; cerebral aneurysm ; microsurgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of a ruptured saccular aneurysm arising from the proximal portion of a partially duplicated basilar artery in a 36-year-old woman is reported. CT and lumbar puncture confirmed subarachnoid haemorrhage. Cerebral angiography detected a vertebrobasilar junction aneurysm associated with basilar artery fenestration. The patient underwent successful clipping and coating of the aneurysm by a right lateral suboccipital osteoclastic approach. Embryological development, pathogenesis, diagnostic and therapeutic difficulties of this vascular malformation are discussed in this report.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 142 (2000), S. 601-602 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Akustikusneurinom ; Stereotaktische Radiochirurgie ; γ-Knife ; Hirnnervenfunktion ; Key words Acoustic neurinoma ; Stereotactic radiosurgery ; Gamma Knife ; Cranial nerve preservation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary From April 1992 to July 1998 stereotactic radiosurgery (Gamma Knife) was used to treat 1382 patients; 181 had acoustic neurinomas and were followed up, 44 of them for at least 4 years (48–75 months, median 60). With no mortality control of growth tumor was achieved in all cases but one. It was possible to preserve useful hearing in more than half of the patients (60%). In two patients complications due to the radiation with enlargement of the cystic component were observed. One patient needed additional microsurgical decompression. Three patients suffered transient incomplete facial palsy (one permanent, HBI III), and two patients complained of mild trigeminal neuropathy. One suffered from hydrocephalus and a shunting procedure was necessary. The neurological state improved in 23 patients (52%); five complained of new or worsened deficits. Radiosurgery is an effective alternative treatment for acoustic neurinomas with exceptionally low mortality and morbidity. With respect to preserving cranial nerve function the results are just as good as those of microsurgical resection. Short duration of hospitalization and quick return to normal activities make radiosurgery quite cost effective.
    Notes: Zusammenfassung Von April 1992 bis Ende Juli 1998 wurden an der Universitätsklinik für Neurochirugie in Graz 1382 Patienten mittels stereotaktischer Radiochirurgie (γ-Knife) behandelt. 181 Patienten hatten Akustikusneurinome; 44 sind nun mindestens 4 Jahre beobachtet worden (48–75, Median 60 Monate). Bei fehlender Mortalität fand sich nur in einem Fall Tumorwachstum. Das präoperativ vorhandene „gebrauchsfähige” Gehör blieb in mehr als der Hälfte der Patienten erhalten (60%); 2 Patienten mit zystischen Anteilen wiesen als Bestrahlungsfolge eine Vergrößerung auf, ein Patient mußte nachoperiert werden; 3 Fazialisparesen und 2 Trigeminusschädigungen traten transient auf, eine Fazialisparese (HBI III) persistierte. Ein Patient entwickelte einen Hydrozephalus und wurde geshuntet. Der neurologische Befund hatte sich bei 23 Patienten (52%) gebessert, 5 Patienten klagten über neu auftretende bzw. verschlechterte Defizite (11%). Die Radiochirurgie ist eine wirkungsvolle alternative Behandlungsform für Akustikusneurinome mit fehlender Mortalität und niedriger Morbidität. Eine 2tägige Krankenhausaufenthaltsdauer und eine sofortige Rückkehr zu den normalen Aktivitäten des täglichen Lebens machen die Behandlung auch hinsichtlich der Kosten vorteilhaft.
    Type of Medium: Electronic Resource
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