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  • 1
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Rat cerebral cortex slices were incubated in vitro with [3H]dopamine (DA) or [3H]noradrenaline (NA) (10−7M), superfused by fresh buffer and stimulated by an electric field. The stimulation-induced overflow of [3H]DA and [3H]NA was determined.In slices from untreated rats about 16 ng [3H]NA/g tissue was formed from [3H]DA, corresponding to about 5 per cent of the endogenous NA concentration. Stimulation markedly enhanced the overflow of [3H]NA. The [3H]NA newly formed from [3H]DA was overflowing to a greater extent than [3H]NA previously taken up from the incubation medium, indicating a preferential release of newly synthesized transmitter. The stimulation-induced overflow of [3H]DA and [3H]NA was increased in slices of rats pretreated with a tyrosine hydroxylase inhibitor (H44/68). It seems that depletion of the endogenous NA stores of central NA neurons by tyrosine hydroxylase inhibition makes the [3H]cate-cholamines more available for release. Pretreatment of the rats with the DA-β-hydroxylase inhibitors FLA63 or FLA69 considerably diminished the formation of [3H]NA from [3H]DA. Stimulation markedly enhanced the overflow of [3H]DA indicating that DA can act as a ‘false transmitter’ in central NA neurons after DA-β-hydroxylase inhibition.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 7 (1983), S. 385-389 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les modifications de la concentration dans le plasma de la catécholamine et de la gastrine ainsi que les modifications de la secrétion d'acide gastrique après repas d'épreuve simulé ont été étudiées chez 7 malades atteints d'ulcère duodénal avant la vagotomie hypersélective et 6 semaines après celle-ci. La sécrétion basale et le pic de la sécrétion acide furent réduits après la vagotomie hypersélective. Les concentrations de la noradrénaline plasmatique qui étaient élevées chez les ulcéreux revirent à la normale après l'intervention. En revanche, les taux de l'adrénaline plasmatique qui étaient voisins de la normale avant l'intervention ne varièrent pas après celle-ci. Les taux de la gastrine plasmatique furent sensiblement plus élevés après la vagotomie hypersélective. Cette étude permet d'affirmer que le repas d'épreuve simulée ne produit pas de modification significative des taux de la catécholamine et de la gastrine plasmatique avant ou après vagotomie hypersélective, mais, en revanche, l'intervention est suivie de la diminution du taux de la noradrénaline. On peut conclure de l'ensemble de ces faits que la noradrénaline est impliquée dans la genèse de la maladie ulcéreuse ou qu'elle en constitue le reflet.
    Abstract: Abstracto Los cambios en las concentraciones plasmáticas de catecolamina y de gastrina y en la secreción de ácido gástrico en respuesta a una comida fantasma (sham feeding), fueron investigados en 7 pacientes con Úlcera duodenal (DU) antes y 6 semanas después de vagotomía altamente selectiva (HSV). Tanto la secreción basal como la secreción pico en respuesta a una comida fantasma modificada, fueron reducidas en forma significativa por la HSV. Las concentraciones plasmáticas de noradrenalina se encontraban elevadas en pacientes con UD, pero descendieron a valores normales después de HSV. Las concentraciones plasmáticas de adrenalina estuvieron dentro de límites normales y no cambiaron después de HSV. Las concentraciones basales de gastrina se hallaron significativamente más altas después de HSV que antes. La comida fantasma modificada no causó cambios significativos en las concentraciones plasmáticas de catecolamina y de gastrina, ni pre ni postoperatoriamente. Se concluye que la noradrenalina está involucrada en, o es un reflejo de la enfermedad ulcerosa duodenal.
    Notes: Abstract The changes in plasma catecholamine and gastrin concentrations and gastric acid secretion in response to modified sham feeding were investigated in 7 duodenal ulcer (DU) patients before and 6 weeks after highly selective vagotomy (HSV). Both basal and peak acid secretion in response to modified sham feeding were significantly reduced by HSV. Basal plasma noradrenaline concentrations were elevated in DU patients but fell to normal values after HSV. Plasma adrenaline concentrations were within the normal range and did not change after HSV. Basal gastrin concentrations were significantly higher after HSV than before. Modified sham feeding caused no significant changes in plasma catecholamine and gastrin concentrations either pre- or postoperatively. It is concluded that noradrenaline is involved in, or reflects, DU disease.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Regulatory Peptides 1 (1980), S. S57 
    ISSN: 0167-0115
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-2568
    Keywords: catecholamines ; duodenal ulcer ; gastric acid ; G-1 hormones ; noradrenaline ; sympathoadrenal system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It is not known if the increased plasma concentration of noradrenaline in patients with chronic duodenal ulcer disease is a pathogenetic factor or not. The aim of the present study was to investigate if physiologic changes of noradrenaline would evoke any alterations in gastric acid secretion or in the plasma concentration of some gastrointestinal hormones (gastrin, secretin, PP, PYY, and GIP) known to affect gastric physiology. The results show that basal plasma noradrenaline concentration was 1.8 nM and after infusion with noradrenaline at 0.04 or 0.2 nmol/kg/min plasma levels of 2.5 and 4.4 nM were obtained. No appreciable changes could be found in basal or pentagastrin stimulated acid secretion or in any of the gastrointestinal peptides studied. If the elevated plasma noradrenaline concentration observed in duodenal ulcer patients is a pathogenetic factor; it is probable that it interferes with other variables such as blood flow, bicarbonate secretion, or prostaglandin synthesis.
    Type of Medium: Electronic Resource
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